Transgene‐mediated hyper‐expression of IL‐5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus

IL‐5 preferentially activates B1 cells to produce natural antibodies cross‐reactive to self antigens. To determine the role of IL‐5 in antibody‐mediated autoimmune disease, we generated systemic lupus erythematosus (SLE)‐prone (NZB×NZW)F1 mice congenic for IL‐5 transgene (TG‐F1). The transgene unexp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of immunology 2004-10, Vol.34 (10), p.2740-2749
Hauptverfasser:	Wen, Xiangshu, Zhang, Danqing, Kikuchi, Yuji, Jiang, Yi, Nakamura, Kazuhiro, Xiu, Yan, Tsurui, Hiromichi, Takahashi, Kazuko, Abe, Masaaki, Ohtsuji, Mareki, Nishimura, Hiroyuki, Takatsu, Kiyoshi, Shirai, Toshikazu, Hirose, Sachiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Antinuclear - blood B-Lymphocyte Subsets - immunology B-Lymphocytes - immunology B1 cells Blotting, Southern B cell chronic lymphocytic leukemia Enzyme-Linked Immunosorbent Assay Flow Cytometry Fluorescent Antibody Technique IL‐5 Immunoglobulin G - blood Immunoglobulin M - blood Interleukin-5 - genetics Interleukin-5 - immunology Leukemia, Lymphocytic, Chronic, B-Cell - etiology Leukemia, Lymphocytic, Chronic, B-Cell - immunology Lupus Erythematosus, Systemic - immunology Lupus Nephritis - immunology Mice Mice, Transgenic SLE Transgenes Transgenic mice
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!