Detection of low‐frequency human antigen‐specific CD4+ T cells using MHC class II multimer bead sorting and immunoscope analysis

MHC class II tetramers are attractive tools to study antigen‐specific CD4+ T cell responses in various clinical situations in humans. HLA‐DRA1*0101/DRB1*0401 MHC class II heterodimers were produced as empty molecules using the Drosophila melanogaster expression system. Peptide binding experiments re...

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Veröffentlicht in:	European journal of immunology 2004-10, Vol.34 (10), p.2841-2949
Hauptverfasser:	Lemaître, Fabrice, Viguier, Manuelle, Cho, Min‐Sun, Fourneau, Jean‐Marie, Maillère, Bernard, Kourilsky, Philippe, van Endert, Peter M., Ferradini, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - immunology CD4-Positive T-Lymphocytes - immunology Drosophila melanogaster Epitopes, T-Lymphocyte - immunology Genetic Vectors Histocompatibility Antigens Class II - immunology HLA‐DR4 Humans Immunologic Techniques Immunoscope analysis Influenza hemagglutinin‐A MHC class II tetramer
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