The usefulness of cytokeratin immunohistochemistry in detection of lymph node micrometastasis in neck dissection specimens
Our study was designed to find out the rate and the characteristics of micrometastasis in cervical lymph nodes using immunohistochemical staining. From 69 patients, 1710 lymph nodes negative for metastasis on hematoxylin-eosin stain, were examined. Immunohistochemical stain was performed using pan-c...
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| Veröffentlicht in: | Otolaryngology-head and neck surgery 2004-09, Vol.131 (3), p.300-306 |
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| creator | Kwon, Soon-Young Kim, Hyung-Jin Woo, Jeong-Su Jung, Kwang-Yoon Kim, Insun |
| description | Our study was designed to find out the rate and the characteristics of micrometastasis in cervical lymph nodes using immunohistochemical staining.
From 69 patients, 1710 lymph nodes negative for metastasis on hematoxylin-eosin stain, were examined. Immunohistochemical stain was performed using pan-cytokeratin AE1/AE3 antibody.
In 13 cases, occult lymph node metastasis was detected by immunohistochemical method. On retrospective review of the hematoxylin-eosin stain by the pathologist, lymph node metastasis was detected in 4 of 13 patients.
Because the immunohistochemical method enhanced the detection rate of occult micrometastasis in cervical lymph nodes of head and neck squamous cell carcinoma patients, it may be recommended for routine diagnostic use in patient with negative for a lymph node metastasis on routine hematoxylin-eosin stain. |
| doi_str_mv | 10.1016/j.otohns.2004.02.020 |
| format | Article |
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From 69 patients, 1710 lymph nodes negative for metastasis on hematoxylin-eosin stain, were examined. Immunohistochemical stain was performed using pan-cytokeratin AE1/AE3 antibody.
In 13 cases, occult lymph node metastasis was detected by immunohistochemical method. On retrospective review of the hematoxylin-eosin stain by the pathologist, lymph node metastasis was detected in 4 of 13 patients.
Because the immunohistochemical method enhanced the detection rate of occult micrometastasis in cervical lymph nodes of head and neck squamous cell carcinoma patients, it may be recommended for routine diagnostic use in patient with negative for a lymph node metastasis on routine hematoxylin-eosin stain.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1016/j.otohns.2004.02.020</identifier><identifier>PMID: 15365551</identifier><language>eng</language><publisher>Los Angeles, CA: Mosby, Inc</publisher><subject>Adult ; Aged ; Carcinoma, Squamous Cell - chemistry ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - secondary ; Carcinoma, Squamous Cell - surgery ; Female ; Head and Neck Neoplasms - chemistry ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - surgery ; Humans ; Immunohistochemistry ; Keratins - analysis ; Lymph Node Excision ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies</subject><ispartof>Otolaryngology-head and neck surgery, 2004-09, Vol.131 (3), p.300-306</ispartof><rights>2004 American Academy of Otolaryngology–Head and Neck Surgery Foundation, Inc.</rights><rights>2004 SAGE Publications</rights><rights>2004 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5192-c2ffdddab0a0616d4fdf67a80e27e986636d6fca92c0297d0bbcb6e73890688d3</citedby><cites>FETCH-LOGICAL-c5192-c2ffdddab0a0616d4fdf67a80e27e986636d6fca92c0297d0bbcb6e73890688d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1016/j.otohns.2004.02.020$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1016/j.otohns.2004.02.020$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,1411,21798,27901,27902,43597,43598,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15365551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwon, Soon-Young</creatorcontrib><creatorcontrib>Kim, Hyung-Jin</creatorcontrib><creatorcontrib>Woo, Jeong-Su</creatorcontrib><creatorcontrib>Jung, Kwang-Yoon</creatorcontrib><creatorcontrib>Kim, Insun</creatorcontrib><title>The usefulness of cytokeratin immunohistochemistry in detection of lymph node micrometastasis in neck dissection specimens</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description>Our study was designed to find out the rate and the characteristics of micrometastasis in cervical lymph nodes using immunohistochemical staining.
From 69 patients, 1710 lymph nodes negative for metastasis on hematoxylin-eosin stain, were examined. Immunohistochemical stain was performed using pan-cytokeratin AE1/AE3 antibody.
In 13 cases, occult lymph node metastasis was detected by immunohistochemical method. On retrospective review of the hematoxylin-eosin stain by the pathologist, lymph node metastasis was detected in 4 of 13 patients.
Because the immunohistochemical method enhanced the detection rate of occult micrometastasis in cervical lymph nodes of head and neck squamous cell carcinoma patients, it may be recommended for routine diagnostic use in patient with negative for a lymph node metastasis on routine hematoxylin-eosin stain.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Squamous Cell - chemistry</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Female</subject><subject>Head and Neck Neoplasms - chemistry</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - surgery</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Keratins - analysis</subject><subject>Lymph Node Excision</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Retrospective Studies</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVGL1DAUhYOsuOPqPxDp0751vOm0aQMi6OK4wuK-rM8hTW5tZttkzG2V-uvN0AHfVDhwIZzvkHsuY684bDlw8eawDVPoPW0LgHILRRI8YRsOss5Fw-sLtgEuy7ySsrlkz4kOACBEXT9jl7zaiaqq-Ib9eugxmwm7efBIlIUuM8sUHjHqyfnMjePsQ-9oCqbHMc24ZOnd4oRmcsGfgGEZj33mg8VsdCaGESdNSY5OVo_mMbOO6AzQEY0b0dML9rTTA-HL87xiX_cfH25u87v7T59v3t_lpuKyyE3RddZa3YIGwYUtO9uJWjeARY2yEWInrOiMloWBQtYW2ta0AutdI0E0jd1dses19xjD9xlpUmkPg8OgPYaZlBBNXZVcJGO5GtMORBE7dYxu1HFRHNSpc3VQa-fq1LmCIgkS9vqcP7cj2j_QueRkeLsafroBl_8KVfe3Xz7suaxkkXC-4qS_oTqEOfpU17_-9G5lMBX7w2FUZBx6g9bFdAdlg_t7wG_4PrwV</recordid><startdate>200409</startdate><enddate>200409</enddate><creator>Kwon, Soon-Young</creator><creator>Kim, Hyung-Jin</creator><creator>Woo, Jeong-Su</creator><creator>Jung, Kwang-Yoon</creator><creator>Kim, Insun</creator><general>Mosby, Inc</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200409</creationdate><title>The usefulness of cytokeratin immunohistochemistry in detection of lymph node micrometastasis in neck dissection specimens</title><author>Kwon, Soon-Young ; Kim, Hyung-Jin ; Woo, Jeong-Su ; Jung, Kwang-Yoon ; Kim, Insun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5192-c2ffdddab0a0616d4fdf67a80e27e986636d6fca92c0297d0bbcb6e73890688d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Squamous Cell - chemistry</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Female</topic><topic>Head and Neck Neoplasms - chemistry</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - surgery</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Keratins - analysis</topic><topic>Lymph Node Excision</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwon, Soon-Young</creatorcontrib><creatorcontrib>Kim, Hyung-Jin</creatorcontrib><creatorcontrib>Woo, Jeong-Su</creatorcontrib><creatorcontrib>Jung, Kwang-Yoon</creatorcontrib><creatorcontrib>Kim, Insun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwon, Soon-Young</au><au>Kim, Hyung-Jin</au><au>Woo, Jeong-Su</au><au>Jung, Kwang-Yoon</au><au>Kim, Insun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The usefulness of cytokeratin immunohistochemistry in detection of lymph node micrometastasis in neck dissection specimens</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2004-09</date><risdate>2004</risdate><volume>131</volume><issue>3</issue><spage>300</spage><epage>306</epage><pages>300-306</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>Our study was designed to find out the rate and the characteristics of micrometastasis in cervical lymph nodes using immunohistochemical staining.
From 69 patients, 1710 lymph nodes negative for metastasis on hematoxylin-eosin stain, were examined. Immunohistochemical stain was performed using pan-cytokeratin AE1/AE3 antibody.
In 13 cases, occult lymph node metastasis was detected by immunohistochemical method. On retrospective review of the hematoxylin-eosin stain by the pathologist, lymph node metastasis was detected in 4 of 13 patients.
Because the immunohistochemical method enhanced the detection rate of occult micrometastasis in cervical lymph nodes of head and neck squamous cell carcinoma patients, it may be recommended for routine diagnostic use in patient with negative for a lymph node metastasis on routine hematoxylin-eosin stain.</abstract><cop>Los Angeles, CA</cop><pub>Mosby, Inc</pub><pmid>15365551</pmid><doi>10.1016/j.otohns.2004.02.020</doi><tpages>7</tpages></addata></record> |
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| ispartof | Otolaryngology-head and neck surgery, 2004-09, Vol.131 (3), p.300-306 |
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| subjects | Adult Aged Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - surgery Female Head and Neck Neoplasms - chemistry Head and Neck Neoplasms - pathology Head and Neck Neoplasms - surgery Humans Immunohistochemistry Keratins - analysis Lymph Node Excision Lymphatic Metastasis Male Middle Aged Neoplasm Staging Retrospective Studies |
| title | The usefulness of cytokeratin immunohistochemistry in detection of lymph node micrometastasis in neck dissection specimens |
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