Src-protein tyrosine kinases are required for cocaine-induced increase in the expression and function of the NMDA receptor in the ventral tegmental area

Cocaine-induced long-term potentiation of glutamatergic synapses in the ventral tegmental area (VTA) has been proposed as a key process that contributes to the development of addictive behaviors. In particular, the activation of ionotrophic glutamate NMDA receptor (NMDAR) in the VTA is critical for...

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Veröffentlicht in:	Journal of neurochemistry 2009-02, Vol.108 (3), p.697-706
Hauptverfasser:	Schumann, Johanna, Michaeli, Avner, Yaka, Rami
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Addictive behaviors Adult and adolescent clinical studies Animals Biochemistry Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cocaine Cocaine - pharmacology Dopamine Uptake Inhibitors - pharmacology Drug addiction Electrophysiology Excitatory Postsynaptic Potentials - drug effects Fundamental and applied biological sciences. Psychology Indicators and Reagents Long-Term Potentiation - drug effects Male Medical sciences Neurology Neurotransmitters NMDA receptors Patch-Clamp Techniques Phosphorylation Proto-Oncogene Proteins c-fyn - biosynthesis Proto-Oncogene Proteins c-fyn - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats Receptors, N-Methyl-D-Aspartate - biosynthesis Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - genetics Src protein tyrosine kinase src-Family Kinases - metabolism Subcellular Fractions - drug effects Tyrosine - metabolism tyrosine phosphorylation ventral tegmental area Ventral Tegmental Area - drug effects Ventral Tegmental Area - metabolism Vertebrates: nervous system and sense organs
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