Functional brain imaging in pure akinesia with gait freezing: [18F] FDG PET and [18F] FP-CIT PET analyses
Pure akinesia with gait freezing (PAGF) has characteristic features, including freezing of gait and prominent speech disturbance without rigidity or tremor. The purpose of this study was to investigate changes in brain glucose metabolism and presynaptic dopaminergic function in PAGF. By using [18F]...
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| Veröffentlicht in: | Movement disorders 2009-01, Vol.24 (2), p.237-245 |
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| creator | Park, Hee K. Kim, Jae S. Im, Ki C. Oh, Seung J. Kim, Mi J. Lee, Jae-Hong Chung, Sun J. Lee, Myoung C. |
| description | Pure akinesia with gait freezing (PAGF) has characteristic features, including freezing of gait and prominent speech disturbance without rigidity or tremor. The purpose of this study was to investigate changes in brain glucose metabolism and presynaptic dopaminergic function in PAGF. By using [18F] fluorodeoxyglucose (FDG) PET, 11 patients with PAGF were compared with 14 patients with probable progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD), and 11 normal controls. [18F] N‐(3‐fluoropropyl)‐2β‐carbon ethoxy‐3β‐(4‐iodophenyl) nortropane (FP‐CIT) PET was performed in 11 patients with PAGF and with 10 normal controls. The PAGF patients showed decreased glucose metabolism in the midbrain when compared with normal controls. PSP patients showed a similar topographic distribution of glucose hypometabolism with additional areas, including the frontal cortex, when compared with normal controls. The FP‐CIT PET findings in patients with PAGF revealed severely decreased uptake bilaterally in the basal ganglia. These findings suggest that both PAGF and PSP may be part of the same pathophysiologic spectrum of disease. However, the reason why PAGF manifests clinically in a different manner needs to be further elucidated. © 2008 Movement Disorder Society |
| doi_str_mv | 10.1002/mds.22347 |
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The purpose of this study was to investigate changes in brain glucose metabolism and presynaptic dopaminergic function in PAGF. By using [18F] fluorodeoxyglucose (FDG) PET, 11 patients with PAGF were compared with 14 patients with probable progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD), and 11 normal controls. [18F] N‐(3‐fluoropropyl)‐2β‐carbon ethoxy‐3β‐(4‐iodophenyl) nortropane (FP‐CIT) PET was performed in 11 patients with PAGF and with 10 normal controls. The PAGF patients showed decreased glucose metabolism in the midbrain when compared with normal controls. PSP patients showed a similar topographic distribution of glucose hypometabolism with additional areas, including the frontal cortex, when compared with normal controls. The FP‐CIT PET findings in patients with PAGF revealed severely decreased uptake bilaterally in the basal ganglia. These findings suggest that both PAGF and PSP may be part of the same pathophysiologic spectrum of disease. However, the reason why PAGF manifests clinically in a different manner needs to be further elucidated. © 2008 Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.22347</identifier><identifier>PMID: 18951539</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Aged, 80 and over ; Basal Ganglia Diseases - complications ; Basal Ganglia Diseases - diagnostic imaging ; Basal Ganglia Diseases - metabolism ; Biological and medical sciences ; Brain - diagnostic imaging ; Brain - metabolism ; Brain - pathology ; Carbon Radioisotopes ; FDG PET ; Female ; Fluorine Radioisotopes ; Fluorodeoxyglucose F18 ; FP-CIT PET ; Gait Disorders, Neurologic - diagnostic imaging ; Gait Disorders, Neurologic - etiology ; Gait Disorders, Neurologic - metabolism ; Glucose - metabolism ; Humans ; Hypokinesia - diagnostic imaging ; Hypokinesia - etiology ; Hypokinesia - metabolism ; Investigative techniques, diagnostic techniques (general aspects) ; Iodine Radioisotopes ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Mesencephalon - diagnostic imaging ; Mesencephalon - metabolism ; Middle Aged ; Nervous system ; Neurology ; Parkinson Disease - complications ; Parkinson Disease - diagnostic imaging ; Positron-Emission Tomography ; progressive supranuclear palsy ; pure akinesia with gait freezing ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Radiopharmaceuticals ; Supranuclear Palsy, Progressive - complications ; Supranuclear Palsy, Progressive - diagnostic imaging ; Tropanes</subject><ispartof>Movement disorders, 2009-01, Vol.24 (2), p.237-245</ispartof><rights>Copyright © 2008 Movement Disorder Society</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4227-f659a82c398e14641a76db70b352b83d7ecf71a7c7521322db57ebce33b2bbb33</citedby><cites>FETCH-LOGICAL-c4227-f659a82c398e14641a76db70b352b83d7ecf71a7c7521322db57ebce33b2bbb33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.22347$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.22347$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21119776$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18951539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Hee K.</creatorcontrib><creatorcontrib>Kim, Jae S.</creatorcontrib><creatorcontrib>Im, Ki C.</creatorcontrib><creatorcontrib>Oh, Seung J.</creatorcontrib><creatorcontrib>Kim, Mi J.</creatorcontrib><creatorcontrib>Lee, Jae-Hong</creatorcontrib><creatorcontrib>Chung, Sun J.</creatorcontrib><creatorcontrib>Lee, Myoung C.</creatorcontrib><title>Functional brain imaging in pure akinesia with gait freezing: [18F] FDG PET and [18F] FP-CIT PET analyses</title><title>Movement disorders</title><addtitle>Mov. Disord</addtitle><description>Pure akinesia with gait freezing (PAGF) has characteristic features, including freezing of gait and prominent speech disturbance without rigidity or tremor. The purpose of this study was to investigate changes in brain glucose metabolism and presynaptic dopaminergic function in PAGF. By using [18F] fluorodeoxyglucose (FDG) PET, 11 patients with PAGF were compared with 14 patients with probable progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD), and 11 normal controls. [18F] N‐(3‐fluoropropyl)‐2β‐carbon ethoxy‐3β‐(4‐iodophenyl) nortropane (FP‐CIT) PET was performed in 11 patients with PAGF and with 10 normal controls. The PAGF patients showed decreased glucose metabolism in the midbrain when compared with normal controls. PSP patients showed a similar topographic distribution of glucose hypometabolism with additional areas, including the frontal cortex, when compared with normal controls. The FP‐CIT PET findings in patients with PAGF revealed severely decreased uptake bilaterally in the basal ganglia. These findings suggest that both PAGF and PSP may be part of the same pathophysiologic spectrum of disease. However, the reason why PAGF manifests clinically in a different manner needs to be further elucidated. © 2008 Movement Disorder Society</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Basal Ganglia Diseases - complications</subject><subject>Basal Ganglia Diseases - diagnostic imaging</subject><subject>Basal Ganglia Diseases - metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Carbon Radioisotopes</subject><subject>FDG PET</subject><subject>Female</subject><subject>Fluorine Radioisotopes</subject><subject>Fluorodeoxyglucose F18</subject><subject>FP-CIT PET</subject><subject>Gait Disorders, Neurologic - diagnostic imaging</subject><subject>Gait Disorders, Neurologic - etiology</subject><subject>Gait Disorders, Neurologic - metabolism</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Hypokinesia - diagnostic imaging</subject><subject>Hypokinesia - etiology</subject><subject>Hypokinesia - metabolism</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Iodine Radioisotopes</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesencephalon - diagnostic imaging</subject><subject>Mesencephalon - metabolism</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - diagnostic imaging</subject><subject>Positron-Emission Tomography</subject><subject>progressive supranuclear palsy</subject><subject>pure akinesia with gait freezing</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Radiopharmaceuticals</subject><subject>Supranuclear Palsy, Progressive - complications</subject><subject>Supranuclear Palsy, Progressive - diagnostic imaging</subject><subject>Tropanes</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFv0zAUhS0EYmXwwB9AfgGJh2y5dh07vKFu6QYDKlGEBEKW7dwUszQtdqKt_Ho8mo0nxJOto-_ec3UOIU8hP4I8Z8frOh4xxqfyHpmA4JApJuR9MsmVEhkHJQ7Ioxh_5DmAgOIhOQBVigSWE-KroXO933SmpTYY31G_NivfrWj6boeA1Fz6DqM39Mr33-nK-J42AfFXYl7Rr6Cqb7Q6mdPF6ZKarr5VFtnsfDmKpt1FjI_Jg8a0EZ-M7yH5VJ0uZ2fZxYf5-ez1ReamjMmsKURpFHO8VAjTYgpGFrWVueWCWcVria6RSXRSMOCM1VZItA45t8xay_khebHfuw2bnwPGXq99dNi2psPNEHVRKCmgLP4LMkjJAUACX-5BFzYxBmz0NqSUwk5Drm8K0KkA_aeAxD4blw52jfVfckw8Ac9HwERn2iaYzvl4xyVTKKW8ue54z135Fnf_dtTvTj7eWmf7CR97vL6bMOFSF5JLoT-_n-s35dtF9WU515z_BheiqH0</recordid><startdate>20090130</startdate><enddate>20090130</enddate><creator>Park, Hee K.</creator><creator>Kim, Jae S.</creator><creator>Im, Ki C.</creator><creator>Oh, Seung J.</creator><creator>Kim, Mi J.</creator><creator>Lee, Jae-Hong</creator><creator>Chung, Sun J.</creator><creator>Lee, Myoung C.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20090130</creationdate><title>Functional brain imaging in pure akinesia with gait freezing: [18F] FDG PET and [18F] FP-CIT PET analyses</title><author>Park, Hee K. ; Kim, Jae S. ; Im, Ki C. ; Oh, Seung J. ; Kim, Mi J. ; Lee, Jae-Hong ; Chung, Sun J. ; Lee, Myoung C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4227-f659a82c398e14641a76db70b352b83d7ecf71a7c7521322db57ebce33b2bbb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Basal Ganglia Diseases - complications</topic><topic>Basal Ganglia Diseases - diagnostic imaging</topic><topic>Basal Ganglia Diseases - metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Carbon Radioisotopes</topic><topic>FDG PET</topic><topic>Female</topic><topic>Fluorine Radioisotopes</topic><topic>Fluorodeoxyglucose F18</topic><topic>FP-CIT PET</topic><topic>Gait Disorders, Neurologic - diagnostic imaging</topic><topic>Gait Disorders, Neurologic - etiology</topic><topic>Gait Disorders, Neurologic - metabolism</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Hypokinesia - diagnostic imaging</topic><topic>Hypokinesia - etiology</topic><topic>Hypokinesia - metabolism</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Iodine Radioisotopes</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesencephalon - diagnostic imaging</topic><topic>Mesencephalon - metabolism</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - diagnostic imaging</topic><topic>Positron-Emission Tomography</topic><topic>progressive supranuclear palsy</topic><topic>pure akinesia with gait freezing</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Radiopharmaceuticals</topic><topic>Supranuclear Palsy, Progressive - complications</topic><topic>Supranuclear Palsy, Progressive - diagnostic imaging</topic><topic>Tropanes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Hee K.</creatorcontrib><creatorcontrib>Kim, Jae S.</creatorcontrib><creatorcontrib>Im, Ki C.</creatorcontrib><creatorcontrib>Oh, Seung J.</creatorcontrib><creatorcontrib>Kim, Mi J.</creatorcontrib><creatorcontrib>Lee, Jae-Hong</creatorcontrib><creatorcontrib>Chung, Sun J.</creatorcontrib><creatorcontrib>Lee, Myoung C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Hee K.</au><au>Kim, Jae S.</au><au>Im, Ki C.</au><au>Oh, Seung J.</au><au>Kim, Mi J.</au><au>Lee, Jae-Hong</au><au>Chung, Sun J.</au><au>Lee, Myoung C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional brain imaging in pure akinesia with gait freezing: [18F] FDG PET and [18F] FP-CIT PET analyses</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov. Disord</addtitle><date>2009-01-30</date><risdate>2009</risdate><volume>24</volume><issue>2</issue><spage>237</spage><epage>245</epage><pages>237-245</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><abstract>Pure akinesia with gait freezing (PAGF) has characteristic features, including freezing of gait and prominent speech disturbance without rigidity or tremor. The purpose of this study was to investigate changes in brain glucose metabolism and presynaptic dopaminergic function in PAGF. By using [18F] fluorodeoxyglucose (FDG) PET, 11 patients with PAGF were compared with 14 patients with probable progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD), and 11 normal controls. [18F] N‐(3‐fluoropropyl)‐2β‐carbon ethoxy‐3β‐(4‐iodophenyl) nortropane (FP‐CIT) PET was performed in 11 patients with PAGF and with 10 normal controls. The PAGF patients showed decreased glucose metabolism in the midbrain when compared with normal controls. PSP patients showed a similar topographic distribution of glucose hypometabolism with additional areas, including the frontal cortex, when compared with normal controls. The FP‐CIT PET findings in patients with PAGF revealed severely decreased uptake bilaterally in the basal ganglia. These findings suggest that both PAGF and PSP may be part of the same pathophysiologic spectrum of disease. However, the reason why PAGF manifests clinically in a different manner needs to be further elucidated. © 2008 Movement Disorder Society</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>18951539</pmid><doi>10.1002/mds.22347</doi><tpages>9</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Basal Ganglia Diseases - complications Basal Ganglia Diseases - diagnostic imaging Basal Ganglia Diseases - metabolism Biological and medical sciences Brain - diagnostic imaging Brain - metabolism Brain - pathology Carbon Radioisotopes FDG PET Female Fluorine Radioisotopes Fluorodeoxyglucose F18 FP-CIT PET Gait Disorders, Neurologic - diagnostic imaging Gait Disorders, Neurologic - etiology Gait Disorders, Neurologic - metabolism Glucose - metabolism Humans Hypokinesia - diagnostic imaging Hypokinesia - etiology Hypokinesia - metabolism Investigative techniques, diagnostic techniques (general aspects) Iodine Radioisotopes Magnetic Resonance Imaging Male Medical sciences Mesencephalon - diagnostic imaging Mesencephalon - metabolism Middle Aged Nervous system Neurology Parkinson Disease - complications Parkinson Disease - diagnostic imaging Positron-Emission Tomography progressive supranuclear palsy pure akinesia with gait freezing Radiodiagnosis. Nmr imagery. Nmr spectrometry Radiopharmaceuticals Supranuclear Palsy, Progressive - complications Supranuclear Palsy, Progressive - diagnostic imaging Tropanes |
| title | Functional brain imaging in pure akinesia with gait freezing: [18F] FDG PET and [18F] FP-CIT PET analyses |
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