Continuous antigenic stimulation system (CASS) as a new immunization strategy

Protection against diseases is mediated by a sustained immune response. Here, we describe a new immunization strategy. Mice implanted with encapsulated C2C12 myoblasts secreting human factor IX (hFIX) elicited a strong humoral response against the transgene, as compared to mice immunized with comple...

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Veröffentlicht in:	Vaccine 2004-09, Vol.22 (29), p.3902-3910
Hauptverfasser:	Gomez-Vargas, Andrew, Rosenthal, Kenneth L., McDermott, Mark R., Hortelano, Gonzalo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation Antigen stimulation system Antigens Antigens - administration & dosage Antigens - genetics Antigens - immunology Applied microbiology Biological and medical sciences Biological Availability Cell Line Cross Reactions Delayed-Action Preparations Factor IX - administration & dosage Factor IX - genetics Factor IX - immunology Fundamental and applied biological sciences. Psychology Gene Expression Regulation Human factors Humans Immune response Immune system Immunity, Cellular Immunization Immunization - methods Immunization strategy Immunoglobulin G - blood Interferon-gamma - analysis Lymphocyte Activation Lymphocytes Mice Mice, Inbred C57BL Microbiology Myoblasts Studies T-Lymphocytes, Cytotoxic - immunology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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