TRPM4 impacts on Ca2+ signals during agonist-induced insulin secretion in pancreatic beta-cells

TRPM4 is a Ca(2+)-activated non-selective cation (CAN) channel that functions in cell depolarization, which is important for Ca(2+) influx and insulin secretion in pancreatic beta-cells. We investigated TRPM4 expression and function in the beta-cell lines HIT-T15 (hamster), RINm5F (rat), beta-TC3 (m...

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Veröffentlicht in:	Molecular and cellular endocrinology 2009-02, Vol.299 (2), p.194-203
Hauptverfasser:	Marigo, V, Courville, K, Hsu, W H, Feng, J M, Cheng, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - pharmacology Calcium Signaling - drug effects Cell Line Cricetinae Glucose - pharmacology Glyburide - pharmacology Humans Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Mice Potassium Chloride - pharmacology Rats TRPM Cation Channels - antagonists & inhibitors TRPM Cation Channels - metabolism
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