High Detection Rates of Colorectal Neoplasia by Stool DNA Testing With a Novel Digital Melt Curve Assay

Background & Aims Current stool DNA tests identify about half of individuals with colorectal cancers and miss most individuals with advanced adenomas. We developed a digital melt curve (DMC) assay to quantify low-abundance mutations in stool samples for detection of colorectal neoplasms and comp...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2009-02, Vol.136 (2), p.459-470
Hauptverfasser:	Zou, Hongzhi, Taylor, William R, Harrington, Jonathan J, Hussain, Fareeda Taher Nazer, Cao, Xiaoming, Loprinzi, Charles L, Levine, Theodore R, Rex, Douglas K, Ahnen, Dennis, Knigge, Kandice L, Lance, Peter, Jiang, Xuan, Smith, David I, Ahlquist, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - diagnosis Adenoma - genetics Aged Case-Control Studies Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Diagnostic Tests, Routine - methods DNA, Neoplasm - genetics Feces Female Gastroenterology and Hepatology Humans Male Mass Screening - methods Middle Aged Mutation Occult Blood Polymerase Chain Reaction - methods Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics Sensitivity and Specificity Tumor Suppressor Protein p53 - genetics
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