The Factor VIIIa C2 Domain (Residues 2228–2240) Interacts with the Factor IXa Gla Domain in the Factor Xase Complex

Factor VIIIa functions as a cofactor for factor IXa in the phospholipid surface-dependent activation of factor X. Both the C2 domain of factor VIIIa and the Gla domain of factor IXa are involved in phospholipid binding and are required for the activation of factor X. In this study, we have examined...

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Veröffentlicht in:	The Journal of biological chemistry 2009-02, Vol.284 (6), p.3379-3388
Hauptverfasser:	Soeda, Tetsuhiro, Nogami, Keiji, Nishiya, Katsumi, Takeyama, Masahiro, Ogiwara, Kenichi, Sakata, Yoichi, Yoshioka, Akira, Shima, Midori
Format:	Artikel
Sprache:	eng
Schlagworte:	Cysteine Endopeptidases - chemistry Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism Enzyme Activation - physiology Factor IXa - chemistry Factor IXa - genetics Factor IXa - metabolism Factor VIIIa - chemistry Factor VIIIa - genetics Factor VIIIa - metabolism Factor X - chemistry Factor X - genetics Factor X - metabolism Humans Multienzyme Complexes - chemistry Multienzyme Complexes - genetics Multienzyme Complexes - metabolism Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Phospholipids - chemistry Phospholipids - genetics Phospholipids - metabolism Protein Binding - physiology Protein Structure, Tertiary - physiology Surface Plasmon Resonance - methods
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