Down-regulation of Early Sea Urchin Histone H2A Gene Relies on cis Regulative Sequences Located in the 5′ and 3′ Regions and Including the Enhancer Blocker sns

The tandem repeated sea urchin α-histone genes are developmentally regulated by gene-specific promoter elements. Coordinate transcription of the five genes begins after meiotic maturation of the oocyte, continues through cleavage, and reaches its maximum at morula stage, after which these genes are...

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Veröffentlicht in:	Journal of molecular biology 2004-10, Vol.342 (5), p.1367-1377
Hauptverfasser:	Di Caro, Domenica, Melfi, Raffaella, Alessandro, Claudia, Serio, Gaetana, Di Caro, Valentina, Cavalieri, Vincenzo, Palla, Franco, Spinelli, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chloramphenicol O-Acetyltransferase - metabolism Down-Regulation Echinoidea Embryo, Nonmammalian - physiology enhancer blocker Enhancer Elements, Genetic - genetics Gastrula Gene Silencing genomic insulator histone genes Histones - genetics Marine Microinjections Promoter Regions, Genetic Protein Binding Regulatory Sequences, Nucleic Acid - genetics Repetitive Sequences, Nucleic Acid - genetics Sea Urchins - genetics Sequence Deletion - genetics transcriptional repression Transgenes
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