Enhancement of vaccinia vaccine potency by linkage of tumor antigen gene to gene encoding calreticulin
Vaccinia vaccines have become important vectors for antigen-specific immunotherapy. Calreticulin has been shown to enhance MHC class I presentation of linked peptide/protein and may be useful for antigen-specific cancer treatment. An innovative vaccine administering antigen linked to calreticulin vi...
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| Veröffentlicht in: | Vaccine 2004-09, Vol.22 (29), p.3993-4001 |
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| creator | Hsieh, Chia-Jung Kim, Tae Woo Hung, Chien-Fu Juang, Jeremy Moniz, Michelle Boyd, David A.K. He, Liangmei Chen, Pei-Jer Chen, Chien-Hung Wu, T.-C. |
| description | Vaccinia vaccines have become important vectors for antigen-specific immunotherapy. Calreticulin has been shown to enhance MHC class I presentation of linked peptide/protein and may be useful for antigen-specific cancer treatment. An innovative vaccine administering antigen linked to calreticulin via a vaccinia vector may generate a potent antigen-specific antitumor response. We tested the efficacy of linking calreticulin (CRT) to model antigen human papilloma virus type 16 (HPV-16) E7 in the context of a vaccinia vaccine (Vac-CRT/E7). Intraperitoneal vaccination of C57BL/6 mice with Vac-CRT/E7 led to a dramatic increase in E7-specific IFN-γ-secreting CD8
+ T cells and a potent antitumor effect against E7-expressing tumors compared to immunization with Vac-E7 or Vac-CRT. When compared to other chimeric vaccinia vaccines employing various intracellular targeting strategies previously developed in our lab, Vac-CRT/E7 elicited the highest number of E7-specific CD8
+ T cells. Thus, vaccination with vaccinia expressing CRT linked to a tumor antigen may represent an advantageous strategy for cancer immunotherapy. |
| doi_str_mv | 10.1016/j.vaccine.2004.03.057 |
| format | Article |
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+ T cells and a potent antitumor effect against E7-expressing tumors compared to immunization with Vac-E7 or Vac-CRT. When compared to other chimeric vaccinia vaccines employing various intracellular targeting strategies previously developed in our lab, Vac-CRT/E7 elicited the highest number of E7-specific CD8
+ T cells. Thus, vaccination with vaccinia expressing CRT linked to a tumor antigen may represent an advantageous strategy for cancer immunotherapy.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2004.03.057</identifier><identifier>PMID: 15364449</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adenoviridae - genetics ; Animals ; Antigens ; Applied microbiology ; Biological and medical sciences ; Calreticulin ; Calreticulin - genetics ; Calreticulin - immunology ; Cancer ; Cancer immunotherapy ; Cancer Vaccines - genetics ; Cancer Vaccines - immunology ; Cancer Vaccines - therapeutic use ; CD8-Positive T-Lymphocytes - immunology ; Cell Line, Transformed ; Cytokines ; Deoxyribonucleic acid ; DNA ; Experiments ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Genetic Vectors ; Human papillomavirus 16 ; Immune system ; Immunization ; Immunotherapy ; Interferon-gamma - analysis ; Lymphocytes ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Microbiology ; Neoplasm Transplantation ; Neoplasms, Experimental - immunology ; Neoplasms, Experimental - therapy ; Oncogene Proteins, Viral - genetics ; Oncogene Proteins, Viral - immunology ; Papillomaviridae ; Papillomavirus E7 Proteins ; Proteins ; Recombinant Proteins - genetics ; Recombinant Proteins - immunology ; Tumors ; Vaccination ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vaccines, DNA - immunology ; Vaccines, DNA - therapeutic use ; Vaccines, Synthetic - genetics ; Vaccines, Synthetic - immunology ; Vaccines, Synthetic - therapeutic use ; Vaccinia vaccines ; Vaccinia virus - genetics ; Vaccinia virus - immunology ; Variance analysis</subject><ispartof>Vaccine, 2004-09, Vol.22 (29), p.3993-4001</ispartof><rights>2004 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Elsevier Limited Sep 28, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-bf87af89fa7c215458a66e6f703bd8db0a21399e0c43e88c7e254c82a3afaee53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1559058652?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16114705$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15364449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsieh, Chia-Jung</creatorcontrib><creatorcontrib>Kim, Tae Woo</creatorcontrib><creatorcontrib>Hung, Chien-Fu</creatorcontrib><creatorcontrib>Juang, Jeremy</creatorcontrib><creatorcontrib>Moniz, Michelle</creatorcontrib><creatorcontrib>Boyd, David A.K.</creatorcontrib><creatorcontrib>He, Liangmei</creatorcontrib><creatorcontrib>Chen, Pei-Jer</creatorcontrib><creatorcontrib>Chen, Chien-Hung</creatorcontrib><creatorcontrib>Wu, T.-C.</creatorcontrib><title>Enhancement of vaccinia vaccine potency by linkage of tumor antigen gene to gene encoding calreticulin</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Vaccinia vaccines have become important vectors for antigen-specific immunotherapy. Calreticulin has been shown to enhance MHC class I presentation of linked peptide/protein and may be useful for antigen-specific cancer treatment. An innovative vaccine administering antigen linked to calreticulin via a vaccinia vector may generate a potent antigen-specific antitumor response. We tested the efficacy of linking calreticulin (CRT) to model antigen human papilloma virus type 16 (HPV-16) E7 in the context of a vaccinia vaccine (Vac-CRT/E7). Intraperitoneal vaccination of C57BL/6 mice with Vac-CRT/E7 led to a dramatic increase in E7-specific IFN-γ-secreting CD8
+ T cells and a potent antitumor effect against E7-expressing tumors compared to immunization with Vac-E7 or Vac-CRT. When compared to other chimeric vaccinia vaccines employing various intracellular targeting strategies previously developed in our lab, Vac-CRT/E7 elicited the highest number of E7-specific CD8
+ T cells. Thus, vaccination with vaccinia expressing CRT linked to a tumor antigen may represent an advantageous strategy for cancer immunotherapy.</description><subject>Adenoviridae - genetics</subject><subject>Animals</subject><subject>Antigens</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Calreticulin</subject><subject>Calreticulin - genetics</subject><subject>Calreticulin - immunology</subject><subject>Cancer</subject><subject>Cancer immunotherapy</subject><subject>Cancer Vaccines - genetics</subject><subject>Cancer Vaccines - immunology</subject><subject>Cancer Vaccines - therapeutic use</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Cell Line, Transformed</subject><subject>Cytokines</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Experiments</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Genetic Vectors</subject><subject>Human papillomavirus 16</subject><subject>Immune system</subject><subject>Immunization</subject><subject>Immunotherapy</subject><subject>Interferon-gamma - analysis</subject><subject>Lymphocytes</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microbiology</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Experimental - immunology</subject><subject>Neoplasms, Experimental - therapy</subject><subject>Oncogene Proteins, Viral - genetics</subject><subject>Oncogene Proteins, Viral - immunology</subject><subject>Papillomaviridae</subject><subject>Papillomavirus E7 Proteins</subject><subject>Proteins</subject><subject>Recombinant Proteins - genetics</subject><subject>Recombinant Proteins - immunology</subject><subject>Tumors</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Vaccines, DNA - immunology</subject><subject>Vaccines, DNA - therapeutic use</subject><subject>Vaccines, Synthetic - genetics</subject><subject>Vaccines, Synthetic - immunology</subject><subject>Vaccines, Synthetic - therapeutic use</subject><subject>Vaccinia vaccines</subject><subject>Vaccinia virus - genetics</subject><subject>Vaccinia virus - immunology</subject><subject>Variance analysis</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0c-L1TAQB_Aiivtc_ROUgiheWifNz55Elt1VWPCi4C2k6fSZZ5s8k3bh_ffm0cKCB_cQJofPDMl8i-I1gZoAER8P9b2x1nmsGwBWA62ByyfFjihJq4YT9bTYQSNYxQj8vChepHQAAE5J-7y4IJwKxli7K4Zr_8t4ixP6uQxDuQ51ZrtgeQwzensqu1M5Ov_b7PHM5mUKsTR-dnv0ZT5YzmGtWYfe-X1pzRhxdnbJfS-LZ4MZE77a6mXx4-b6-9WX6u7b7derz3eV5ZzOVTcoaQbVDkbahnDGlRECxSCBdr3qOzANoW2LYBlFpazEhjOrGkPNYBA5vSzer3OPMfxZMM16csniOBqPYUlaCCUb0sKjkEhJFAeS4Yf_Qw4gJWdCZPr2H3oIS_T5v1nxFrgSvMmKr8rGkFLEQR-jm0w8aQL6HK0-6G35-hytBqpztLnvzTZ96SbsH7q2LDN4twGT8u6HmHN16cEJQpiE844-rQ5zEPcOo07W5dSwdxHtrPvgHnnKX_RFxE8</recordid><startdate>20040928</startdate><enddate>20040928</enddate><creator>Hsieh, Chia-Jung</creator><creator>Kim, Tae Woo</creator><creator>Hung, Chien-Fu</creator><creator>Juang, Jeremy</creator><creator>Moniz, Michelle</creator><creator>Boyd, David A.K.</creator><creator>He, Liangmei</creator><creator>Chen, Pei-Jer</creator><creator>Chen, Chien-Hung</creator><creator>Wu, T.-C.</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040928</creationdate><title>Enhancement of vaccinia vaccine potency by linkage of tumor antigen gene to gene encoding calreticulin</title><author>Hsieh, Chia-Jung ; 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Psychology</topic><topic>Gene expression</topic><topic>Genetic Vectors</topic><topic>Human papillomavirus 16</topic><topic>Immune system</topic><topic>Immunization</topic><topic>Immunotherapy</topic><topic>Interferon-gamma - analysis</topic><topic>Lymphocytes</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microbiology</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms, Experimental - immunology</topic><topic>Neoplasms, Experimental - therapy</topic><topic>Oncogene Proteins, Viral - genetics</topic><topic>Oncogene Proteins, Viral - immunology</topic><topic>Papillomaviridae</topic><topic>Papillomavirus E7 Proteins</topic><topic>Proteins</topic><topic>Recombinant Proteins - genetics</topic><topic>Recombinant Proteins - immunology</topic><topic>Tumors</topic><topic>Vaccination</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Vaccines, DNA - immunology</topic><topic>Vaccines, DNA - therapeutic use</topic><topic>Vaccines, Synthetic - genetics</topic><topic>Vaccines, Synthetic - immunology</topic><topic>Vaccines, Synthetic - therapeutic use</topic><topic>Vaccinia vaccines</topic><topic>Vaccinia virus - genetics</topic><topic>Vaccinia virus - immunology</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsieh, Chia-Jung</creatorcontrib><creatorcontrib>Kim, Tae Woo</creatorcontrib><creatorcontrib>Hung, Chien-Fu</creatorcontrib><creatorcontrib>Juang, Jeremy</creatorcontrib><creatorcontrib>Moniz, Michelle</creatorcontrib><creatorcontrib>Boyd, David A.K.</creatorcontrib><creatorcontrib>He, Liangmei</creatorcontrib><creatorcontrib>Chen, Pei-Jer</creatorcontrib><creatorcontrib>Chen, Chien-Hung</creatorcontrib><creatorcontrib>Wu, T.-C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsieh, Chia-Jung</au><au>Kim, Tae Woo</au><au>Hung, Chien-Fu</au><au>Juang, Jeremy</au><au>Moniz, Michelle</au><au>Boyd, David A.K.</au><au>He, Liangmei</au><au>Chen, Pei-Jer</au><au>Chen, Chien-Hung</au><au>Wu, T.-C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancement of vaccinia vaccine potency by linkage of tumor antigen gene to gene encoding calreticulin</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2004-09-28</date><risdate>2004</risdate><volume>22</volume><issue>29</issue><spage>3993</spage><epage>4001</epage><pages>3993-4001</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Vaccinia vaccines have become important vectors for antigen-specific immunotherapy. Calreticulin has been shown to enhance MHC class I presentation of linked peptide/protein and may be useful for antigen-specific cancer treatment. An innovative vaccine administering antigen linked to calreticulin via a vaccinia vector may generate a potent antigen-specific antitumor response. We tested the efficacy of linking calreticulin (CRT) to model antigen human papilloma virus type 16 (HPV-16) E7 in the context of a vaccinia vaccine (Vac-CRT/E7). Intraperitoneal vaccination of C57BL/6 mice with Vac-CRT/E7 led to a dramatic increase in E7-specific IFN-γ-secreting CD8
+ T cells and a potent antitumor effect against E7-expressing tumors compared to immunization with Vac-E7 or Vac-CRT. When compared to other chimeric vaccinia vaccines employing various intracellular targeting strategies previously developed in our lab, Vac-CRT/E7 elicited the highest number of E7-specific CD8
+ T cells. Thus, vaccination with vaccinia expressing CRT linked to a tumor antigen may represent an advantageous strategy for cancer immunotherapy.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15364449</pmid><doi>10.1016/j.vaccine.2004.03.057</doi><tpages>9</tpages></addata></record> |
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| subjects | Adenoviridae - genetics Animals Antigens Applied microbiology Biological and medical sciences Calreticulin Calreticulin - genetics Calreticulin - immunology Cancer Cancer immunotherapy Cancer Vaccines - genetics Cancer Vaccines - immunology Cancer Vaccines - therapeutic use CD8-Positive T-Lymphocytes - immunology Cell Line, Transformed Cytokines Deoxyribonucleic acid DNA Experiments Fundamental and applied biological sciences. Psychology Gene expression Genetic Vectors Human papillomavirus 16 Immune system Immunization Immunotherapy Interferon-gamma - analysis Lymphocytes Medical sciences Mice Mice, Inbred C57BL Microbiology Neoplasm Transplantation Neoplasms, Experimental - immunology Neoplasms, Experimental - therapy Oncogene Proteins, Viral - genetics Oncogene Proteins, Viral - immunology Papillomaviridae Papillomavirus E7 Proteins Proteins Recombinant Proteins - genetics Recombinant Proteins - immunology Tumors Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - immunology Vaccines, DNA - therapeutic use Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccines, Synthetic - therapeutic use Vaccinia vaccines Vaccinia virus - genetics Vaccinia virus - immunology Variance analysis |
| title | Enhancement of vaccinia vaccine potency by linkage of tumor antigen gene to gene encoding calreticulin |
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