Multinuclear Non‐Heme Iron Complexes for Double‐Strand DNA Cleavage

Bleomycin mimics: Efficient oxidative double‐strand DNA cleavage has been achieved with multinuclear non‐heme iron complexes (see scheme). These complexes therefore represent model compounds that mimic the mode of action of the anti‐tumor drug bleomycin. The cytotoxicity of the anti‐tumor drug BLM i...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemistry : a European journal 2009-02, Vol.15 (7), p.1723-1733
Hauptverfasser:	Megens, Rik P., van den Berg, Tieme A., de Bruijn, A. Dowine, Feringa, Ben L., Roelfes, Gerard
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism artificial nucleases DNA Breaks, Double-Stranded DNA cleavage double‐strand cleavage iron Iron - chemistry Iron - metabolism Ligands multitopic complexes Oxidation-Reduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!