Isolation and Structural Elucidation of Cyclopentynafil and N-Octylnortadalafil Found in a Dietary Supplement

A new sildenafil analogue, cyclopentynafil (1) and a new tadalafil analogue, N-octylnortadalafil (2) were isolated from a dietary supplement illegally marketed for erectile dysfunction. The structures of the sildenafil and tadalafil analogues were elucidated by using HPLC-photodiode array (PDA), LC-...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2009/02/01, Vol.57(2), pp.185-189
Hauptverfasser:	Hasegawa, Takashi, Takahashi, Kazunaga, Saijo, Masaaki, Ishii, Toshiyasu, Nagata, Tomoko, Kurihara, Masaaki, Haishima, Yuji, Goda, Yukihiro, Kawahara, Nobuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbolines - analysis Carbolines - chemistry Carbolines - isolation & purification Chromatography, High Pressure Liquid Circular Dichroism cyclopentynafil Dietary Supplements - analysis erectile dysfunction Erectile Dysfunction - drug therapy Humans Indicators and Reagents LC-MS Magnetic Resonance Spectroscopy Male N-octylnortadalafil NMR Phosphodiesterase Inhibitors - analysis Phosphodiesterase Inhibitors - chemistry Phosphodiesterase Inhibitors - isolation & purification phosphodiesterase-5 inhibitor Piperazines - analysis Piperazines - chemistry Piperazines - isolation & purification Spectrometry, Mass, Electrospray Ionization Street Drugs - analysis Sulfones - analysis Sulfones - chemistry Sulfones - isolation & purification Tadalafil
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