Global placental gene expression in gestational diabetes mellitus
Objective Gestational diabetes mellitus (GDM) is thought to modify the pattern of placental transcriptome. In a microarray study and a confirmatory quantitative real-time reverse transcription–polymerase chain reaction study, we investigated global placental gene expression in GDM. Study Design Ribo...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2009-02, Vol.200 (2), p.206.e1-206.e13 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Enquobahrie, Daniel A., MD, PhD Williams, Michelle A., ScD Qiu, Chunfang, MD, MS Meller, Margaret, PhD Sorensen, Tanya K., MD |
| description | Objective Gestational diabetes mellitus (GDM) is thought to modify the pattern of placental transcriptome. In a microarray study and a confirmatory quantitative real-time reverse transcription–polymerase chain reaction study, we investigated global placental gene expression in GDM. Study Design Ribonucleic acid was extracted from placental samples collected from 19 GDM cases and 21 controls. Oligonucleotide probes representing 22,000 genes were used to measure gene expression. Differential gene expression was evaluated using the Student t test, fold change assessment, and significance analysis of microarrays. Path analysis was used to assess functions and functional relationships of differentially expressed genes. Results Sixty-six genes participating in cell functions involving cell activation, immune response, organ development, and regulation of cell death were differentially expressed in GDM placentas. These genes include previously described candidate genes (eg, LEP, CEBPA, and MIF), genes with related functions (eg, ADFP), and novel genes (eg, AQP3). Conclusion Expression of genes responsible for diverse biologic processes are modified in GDM. |
| doi_str_mv | 10.1016/j.ajog.2008.08.022 |
| format | Article |
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In a microarray study and a confirmatory quantitative real-time reverse transcription–polymerase chain reaction study, we investigated global placental gene expression in GDM. Study Design Ribonucleic acid was extracted from placental samples collected from 19 GDM cases and 21 controls. Oligonucleotide probes representing 22,000 genes were used to measure gene expression. Differential gene expression was evaluated using the Student t test, fold change assessment, and significance analysis of microarrays. Path analysis was used to assess functions and functional relationships of differentially expressed genes. Results Sixty-six genes participating in cell functions involving cell activation, immune response, organ development, and regulation of cell death were differentially expressed in GDM placentas. These genes include previously described candidate genes (eg, LEP, CEBPA, and MIF), genes with related functions (eg, ADFP), and novel genes (eg, AQP3). Conclusion Expression of genes responsible for diverse biologic processes are modified in GDM.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2008.08.022</identifier><identifier>PMID: 18845290</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Biological and medical sciences ; Diabetes, Gestational - genetics ; Diabetes, Gestational - metabolism ; Female ; Gene Expression ; gestational diabetes mellitus ; global gene expression ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; microarray ; Obstetrics and Gynecology ; Oligonucleotide Array Sequence Analysis ; placenta ; Placenta - metabolism ; Pregnancy</subject><ispartof>American journal of obstetrics and gynecology, 2009-02, Vol.200 (2), p.206.e1-206.e13</ispartof><rights>Mosby, Inc.</rights><rights>2009 Mosby, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-8c621c7a7e461f3510860e48d89bd8c55a31d3e22b825ad9081d8c963e0d2a7a3</citedby><cites>FETCH-LOGICAL-c439t-8c621c7a7e461f3510860e48d89bd8c55a31d3e22b825ad9081d8c963e0d2a7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2008.08.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21093080$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18845290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Enquobahrie, Daniel A., MD, PhD</creatorcontrib><creatorcontrib>Williams, Michelle A., ScD</creatorcontrib><creatorcontrib>Qiu, Chunfang, MD, MS</creatorcontrib><creatorcontrib>Meller, Margaret, PhD</creatorcontrib><creatorcontrib>Sorensen, Tanya K., MD</creatorcontrib><title>Global placental gene expression in gestational diabetes mellitus</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective Gestational diabetes mellitus (GDM) is thought to modify the pattern of placental transcriptome. In a microarray study and a confirmatory quantitative real-time reverse transcription–polymerase chain reaction study, we investigated global placental gene expression in GDM. Study Design Ribonucleic acid was extracted from placental samples collected from 19 GDM cases and 21 controls. Oligonucleotide probes representing 22,000 genes were used to measure gene expression. Differential gene expression was evaluated using the Student t test, fold change assessment, and significance analysis of microarrays. Path analysis was used to assess functions and functional relationships of differentially expressed genes. Results Sixty-six genes participating in cell functions involving cell activation, immune response, organ development, and regulation of cell death were differentially expressed in GDM placentas. These genes include previously described candidate genes (eg, LEP, CEBPA, and MIF), genes with related functions (eg, ADFP), and novel genes (eg, AQP3). Conclusion Expression of genes responsible for diverse biologic processes are modified in GDM.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Diabetes, Gestational - genetics</subject><subject>Diabetes, Gestational - metabolism</subject><subject>Female</subject><subject>Gene Expression</subject><subject>gestational diabetes mellitus</subject><subject>global gene expression</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>microarray</subject><subject>Obstetrics and Gynecology</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>placenta</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVFrFDEQx4Mo9qx-AR_kXuzbnpPJbTYLIpSiVSj40Pocsslcybq3e2Z2S_vtTbhDwQchkMzkNzN__iPEWwkbCVJ_6Deun-43CGA25SA-EysJbVNpo81zsQIArFrVmDPxirkvIbb4UpxJY7Y1trASl9fD1LlhfRicp3HOr3saaU2Ph0TMcRrXccwpnt2cg_wdoutoJl7vaRjivPBr8WLnBqY3p_tc_Pjy-e7qa3Xz_frb1eVN5beqnSvjNUrfuIa2Wu5ULcFooK0Jpu2C8XXtlAyKEDuDtQstGJnTrVYEAV3j1Lm4OPY9pOnXkhXZfWSfRbiRpoWt1qaBPCODeAR9mpgT7ewhxb1LT1aCLcbZ3hbjbDHOloOYi96dui_dnsLfkpNTGXh_Ahx7N-ySG33kPxxm3xWYwn08cpS9eIiULPtIo6cQE_nZhin-X8enf8r9EMeYJ_6kJ-J-WlLeAltpGS3Y27LTsuE8OgswUv0GClWgLA</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Enquobahrie, Daniel A., MD, PhD</creator><creator>Williams, Michelle A., ScD</creator><creator>Qiu, Chunfang, MD, MS</creator><creator>Meller, Margaret, PhD</creator><creator>Sorensen, Tanya K., MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>Global placental gene expression in gestational diabetes mellitus</title><author>Enquobahrie, Daniel A., MD, PhD ; Williams, Michelle A., ScD ; Qiu, Chunfang, MD, MS ; Meller, Margaret, PhD ; Sorensen, Tanya K., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-8c621c7a7e461f3510860e48d89bd8c55a31d3e22b825ad9081d8c963e0d2a7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Diabetes, Gestational - genetics</topic><topic>Diabetes, Gestational - metabolism</topic><topic>Female</topic><topic>Gene Expression</topic><topic>gestational diabetes mellitus</topic><topic>global gene expression</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>microarray</topic><topic>Obstetrics and Gynecology</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>placenta</topic><topic>Placenta - metabolism</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Enquobahrie, Daniel A., MD, PhD</creatorcontrib><creatorcontrib>Williams, Michelle A., ScD</creatorcontrib><creatorcontrib>Qiu, Chunfang, MD, MS</creatorcontrib><creatorcontrib>Meller, Margaret, PhD</creatorcontrib><creatorcontrib>Sorensen, Tanya K., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Enquobahrie, Daniel A., MD, PhD</au><au>Williams, Michelle A., ScD</au><au>Qiu, Chunfang, MD, MS</au><au>Meller, Margaret, PhD</au><au>Sorensen, Tanya K., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Global placental gene expression in gestational diabetes mellitus</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>200</volume><issue>2</issue><spage>206.e1</spage><epage>206.e13</epage><pages>206.e1-206.e13</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective Gestational diabetes mellitus (GDM) is thought to modify the pattern of placental transcriptome. In a microarray study and a confirmatory quantitative real-time reverse transcription–polymerase chain reaction study, we investigated global placental gene expression in GDM. Study Design Ribonucleic acid was extracted from placental samples collected from 19 GDM cases and 21 controls. Oligonucleotide probes representing 22,000 genes were used to measure gene expression. Differential gene expression was evaluated using the Student t test, fold change assessment, and significance analysis of microarrays. Path analysis was used to assess functions and functional relationships of differentially expressed genes. Results Sixty-six genes participating in cell functions involving cell activation, immune response, organ development, and regulation of cell death were differentially expressed in GDM placentas. These genes include previously described candidate genes (eg, LEP, CEBPA, and MIF), genes with related functions (eg, ADFP), and novel genes (eg, AQP3). Conclusion Expression of genes responsible for diverse biologic processes are modified in GDM.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>18845290</pmid><doi>10.1016/j.ajog.2008.08.022</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Biological and medical sciences Diabetes, Gestational - genetics Diabetes, Gestational - metabolism Female Gene Expression gestational diabetes mellitus global gene expression Gynecology. Andrology. Obstetrics Humans Medical sciences microarray Obstetrics and Gynecology Oligonucleotide Array Sequence Analysis placenta Placenta - metabolism Pregnancy |
| title | Global placental gene expression in gestational diabetes mellitus |
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