IL-23 and IFN-γ deficiency in immunodeficient HIV patients who achieved a long-term increase in CD4 T-cell counts on highly active antiretroviral therapy
The pathogenesis of HIV infection and the susceptibility to opportunistic infections has been associated with poor type 1 cytokine production. In severely immunodeficient HIV patients who achieved increased CD4 T-cell counts on longterm highly active antiretroviral therapy, we observed reduced expre...
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| Veröffentlicht in: | AIDS (London) 2004-06, Vol.18 (9), p.1337-1340 |
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| container_title | AIDS (London) |
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| creator | LEE, Silvia FRENCH, Martyn A. H PRICE, Patricia |
| description | The pathogenesis of HIV infection and the susceptibility to opportunistic infections has been associated with poor type 1 cytokine production. In severely immunodeficient HIV patients who achieved increased CD4 T-cell counts on longterm highly active antiretroviral therapy, we observed reduced expression of IL-23p19 and IFN-gamma messenger RNA. Impaired IL-23-induced IFN-gamma production by memory T cells might thus contribute to opportunistic infections in a minority of patients with substantial CD4 T-cell recovery. |
| doi_str_mv | 10.1097/00002030-200406180-00014 |
| format | Article |
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H</creatorcontrib><creatorcontrib>PRICE, Patricia</creatorcontrib><title>IL-23 and IFN-γ deficiency in immunodeficient HIV patients who achieved a long-term increase in CD4 T-cell counts on highly active antiretroviral therapy</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>The pathogenesis of HIV infection and the susceptibility to opportunistic infections has been associated with poor type 1 cytokine production. In severely immunodeficient HIV patients who achieved increased CD4 T-cell counts on longterm highly active antiretroviral therapy, we observed reduced expression of IL-23p19 and IFN-gamma messenger RNA. Impaired IL-23-induced IFN-gamma production by memory T cells might thus contribute to opportunistic infections in a minority of patients with substantial CD4 T-cell recovery.</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>CD4 Lymphocyte Count</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Interferon-gamma - deficiency</subject><subject>Interferon-gamma - genetics</subject><subject>Interleukin-23</subject><subject>Interleukin-23 Subunit p19</subject><subject>Interleukins - deficiency</subject><subject>Interleukins - genetics</subject><subject>Lymphocytes - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Reverse Transcriptase Inhibitors - therapeutic use</subject><subject>RNA, Messenger - analysis</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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Antiparasitic agents</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>CD4 Lymphocyte Count</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - immunology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Interferon-gamma - deficiency</topic><topic>Interferon-gamma - genetics</topic><topic>Interleukin-23</topic><topic>Interleukin-23 Subunit p19</topic><topic>Interleukins - deficiency</topic><topic>Interleukins - genetics</topic><topic>Lymphocytes - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Reverse Transcriptase Inhibitors - therapeutic use</topic><topic>RNA, Messenger - analysis</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEE, Silvia</creatorcontrib><creatorcontrib>FRENCH, Martyn A. H</creatorcontrib><creatorcontrib>PRICE, Patricia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEE, Silvia</au><au>FRENCH, Martyn A. H</au><au>PRICE, Patricia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL-23 and IFN-γ deficiency in immunodeficient HIV patients who achieved a long-term increase in CD4 T-cell counts on highly active antiretroviral therapy</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2004-06-18</date><risdate>2004</risdate><volume>18</volume><issue>9</issue><spage>1337</spage><epage>1340</epage><pages>1337-1340</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>The pathogenesis of HIV infection and the susceptibility to opportunistic infections has been associated with poor type 1 cytokine production. In severely immunodeficient HIV patients who achieved increased CD4 T-cell counts on longterm highly active antiretroviral therapy, we observed reduced expression of IL-23p19 and IFN-gamma messenger RNA. Impaired IL-23-induced IFN-gamma production by memory T cells might thus contribute to opportunistic infections in a minority of patients with substantial CD4 T-cell recovery.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15362668</pmid><doi>10.1097/00002030-200406180-00014</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-9370 |
| ispartof | AIDS (London), 2004-06, Vol.18 (9), p.1337-1340 |
| issn | 0269-9370 1473-5571 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66869812 |
| source | MEDLINE; EZB Electronic Journals Library; Journals@Ovid Complete |
| subjects | Adult AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active Antiviral agents Biological and medical sciences Case-Control Studies CD4 Lymphocyte Count HIV Infections - drug therapy HIV Infections - immunology Human viral diseases Humans Infectious diseases Interferon-gamma - deficiency Interferon-gamma - genetics Interleukin-23 Interleukin-23 Subunit p19 Interleukins - deficiency Interleukins - genetics Lymphocytes - immunology Male Medical sciences Pharmacology. Drug treatments Reverse Transcriptase Inhibitors - therapeutic use RNA, Messenger - analysis Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | IL-23 and IFN-γ deficiency in immunodeficient HIV patients who achieved a long-term increase in CD4 T-cell counts on highly active antiretroviral therapy |
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