A Role of VAMP8/Endobrevin in Regulated Exocytosis of Pancreatic Acinar Cells

Despite our general understanding that members of the SNARE superfamily participate in diverse intracellular docking/fusion events, the physiological role of the majority of SNAREs in the intact organism remains elusive. In this study, through targeted gene knockout in mice, we establish that VAMP8/...

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Veröffentlicht in:	Developmental cell 2004-09, Vol.7 (3), p.359-371
Hauptverfasser:	Wang, Cheng-Chun, Ng, Chee Peng, Lu, Lei, Atlashkin, Vadim, Zhang, Wei, Seet, Li-Fong, Hong, Wanjin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylases - metabolism Animals Blotting, Western Carrier Proteins - metabolism Cell Division Cells, Cultured Endocytosis Exocytosis Fibroblasts - metabolism Genotype Glutathione Transferase - metabolism Immunohistochemistry Liver - metabolism Membrane Proteins - metabolism Membrane Proteins - physiology Mice Mice, Knockout Mice, Transgenic Microscopy, Fluorescence Models, Genetic Pancreas - cytology Pancreas - metabolism Pancreas - physiology Pancreatitis - metabolism Precipitin Tests Qa-SNARE Proteins Qb-SNARE Proteins Qc-SNARE Proteins R-SNARE Proteins SNARE Proteins Time Factors Vesicular Transport Proteins - metabolism
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