Anti-angiogenic and Anti-metastatic Effects of β-1,3-D-Glucan Purified from Hanabiratake, Sparassis crispa

Sparassis crispa (SC), Hanabiratake in Japanese, is an edible mushroom with medicinal properties, that contains more than 40% β-D-glucan. It was concluded from results of the methylation study that β-D-glucan from SC (SBG) was composed of a backbone of β-(1→3)-linked D-glucopyranosyl residues, and h...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2009/02/01, Vol.32(2), pp.259-263
Hauptverfasser:	Yamamoto, Kyosuke, Kimura, Takashi, Sugitachi, Akio, Matsuura, Nariaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Agaricales - chemistry Angiogenesis Inhibitors - isolation & purification Angiogenesis Inhibitors - pharmacology Animals anti-angiogenesis anti-metastasis Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology beta-Glucans - isolation & purification beta-Glucans - pharmacology Capillaries - drug effects Capillaries - pathology Cell Line Cell Movement - drug effects Cell Proliferation - drug effects Female Humans Lung Neoplasms - prevention & control Lung Neoplasms - secondary Melanoma, Experimental - pathology Methylation Mice Mice, Inbred ICR Neoplasm Metastasis - prevention & control Neoplasm Transplantation Neovascularization, Pathologic - pathology Neovascularization, Pathologic - prevention & control Sparassis crispa Structure-Activity Relationship Vascular Endothelial Growth Factor A - pharmacology β-(1→3)-D-glucan
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