The Pediatric Investigators Collaborative Network on Infections in Canada Study of Predictors of Hospitalization for Respiratory Syncytial Virus Infection for Infants Born at 33 Through 35 Completed Weeks of Gestation
BACKGROUND:Infants born at 33 through 35 completed weeks of gestation (33-35GA) are at risk for severe respiratory syncytial virus (RSV) infection, and palivizumab prophylaxis lowers hospitalizations for RSV infection by as much as 80%. The 33-35GA cohort comprises 3-5% of annual births; thus expert...
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| Veröffentlicht in: | The Pediatric infectious disease journal 2004-09, Vol.23 (9), p.806-814 |
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| creator | Law, Barbara J Langley, Joanne M Allen, Upton Paes, Bosco Lee, David S. C Mitchell, Ian Sampalis, John Walti, Hervé Robinson, Joan O’Brien, Karel Majaesic, Carina Caouette, Georges Frenette, Lyne Le Saux, Nicole Simmons, Brian Moisiuk, Sharon Sankaran, Koravanagattu Ojah, Cecil Singh, Avash J Lebel, Marc H Bacheyie, Godfrey S Onyett, Heather Michaliszyn, Andrea Manzi, Patricia Parison, Diana |
| description | BACKGROUND:Infants born at 33 through 35 completed weeks of gestation (33-35GA) are at risk for severe respiratory syncytial virus (RSV) infection, and palivizumab prophylaxis lowers hospitalizations for RSV infection by as much as 80%. The 33-35GA cohort comprises 3-5% of annual births; thus expert panels recommend limiting prophylaxis to situations in which frequency or health care impact of RSV infection is high. This study sought to identify independent risk factors for hospitalization for RSV infection.
METHODS:This was a multicenter, prospective, observational cohort study of 33-35GA infants followed through their first RSV season (2001/2002 or 2002/2003). Baseline data were collected by interview with parents and review of medical records. Respiratory tract illnesses were identified by monthly phone calls, and medical records were reviewed for emergency room visits or hospitalizations. Risk factors were determined by stepwise logistic regression.
RESULTS:Of 1860 enrolled subjects, 1832 (98.5%) were followed for at least 1 month, and 1760 (94.6%) completed all follow-ups. Of 140 (7.6%) subjects hospitalized for respiratory tract illnesses, 66 infants had proven RSV infection. Independent predictors for hospitalization for RSV infection wereday-care attendance (odds ratio, 12.32; 95% confidence interval, 2.56, 59.34); November through January birth (odds ratio, 4.89; 95% confidence interval, 2.57, 9.29); preschool age sibling(s) (odds ratio, 2.76; 95% confidence interval, 1.51, 5.03); birth weight 5 people, counting the subject (odds ratio, 1.79; 95% confidence interval, 1.02, 3.16). Family history of eczema (odds ratio, 0.42; 95% confidence interval, 0.18, 0.996) was protective.
CONCLUSIONS:Specific host/environmental factors can be used to identify which 33-35GA infants are at greatest risk of hospitalization for RSV infection and likely to benefit from palivizumab prophylaxis. |
| doi_str_mv | 10.1097/01.inf.0000137568.71589.bd |
| format | Article |
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METHODS:This was a multicenter, prospective, observational cohort study of 33-35GA infants followed through their first RSV season (2001/2002 or 2002/2003). Baseline data were collected by interview with parents and review of medical records. Respiratory tract illnesses were identified by monthly phone calls, and medical records were reviewed for emergency room visits or hospitalizations. Risk factors were determined by stepwise logistic regression.
RESULTS:Of 1860 enrolled subjects, 1832 (98.5%) were followed for at least 1 month, and 1760 (94.6%) completed all follow-ups. Of 140 (7.6%) subjects hospitalized for respiratory tract illnesses, 66 infants had proven RSV infection. Independent predictors for hospitalization for RSV infection wereday-care attendance (odds ratio, 12.32; 95% confidence interval, 2.56, 59.34); November through January birth (odds ratio, 4.89; 95% confidence interval, 2.57, 9.29); preschool age sibling(s) (odds ratio, 2.76; 95% confidence interval, 1.51, 5.03); birth weight <10th percentile (odds ratio, 2.19; 95% confidence interval, 1.14, 4.22); male gender (odds ratio, 1.91; 95% confidence interval, 1.10, 3.31); ≥2 smokers in the home (odds ratio, 1.87; 95% confidence interval, 1.07, 3.26); and households with >5 people, counting the subject (odds ratio, 1.79; 95% confidence interval, 1.02, 3.16). Family history of eczema (odds ratio, 0.42; 95% confidence interval, 0.18, 0.996) was protective.
CONCLUSIONS:Specific host/environmental factors can be used to identify which 33-35GA infants are at greatest risk of hospitalization for RSV infection and likely to benefit from palivizumab prophylaxis.</description><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 1532-0987</identifier><identifier>DOI: 10.1097/01.inf.0000137568.71589.bd</identifier><identifier>PMID: 15361717</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Antibodies, Monoclonal - therapeutic use ; Antibodies, Monoclonal, Humanized ; Canada - epidemiology ; Cohort Studies ; Female ; Gestational Age ; Hospitalization - statistics & numerical data ; Humans ; Infant, Newborn ; Infant, Premature ; Logistic Models ; Male ; Multivariate Analysis ; Palivizumab ; Predictive Value of Tests ; Pregnancy ; Prevalence ; Probability ; Respiratory Syncytial Virus Infections - diagnosis ; Respiratory Syncytial Virus Infections - drug therapy ; Respiratory Syncytial Virus Infections - epidemiology ; Risk Assessment ; Severity of Illness Index ; Sex Factors ; Survival Rate ; Treatment Outcome</subject><ispartof>The Pediatric infectious disease journal, 2004-09, Vol.23 (9), p.806-814</ispartof><rights>2004 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3606-1eff605e340464560393067dc3bb73438751068dcf4b395e2401b20e0525d3ea3</citedby><cites>FETCH-LOGICAL-c3606-1eff605e340464560393067dc3bb73438751068dcf4b395e2401b20e0525d3ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15361717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Law, Barbara J</creatorcontrib><creatorcontrib>Langley, Joanne M</creatorcontrib><creatorcontrib>Allen, Upton</creatorcontrib><creatorcontrib>Paes, Bosco</creatorcontrib><creatorcontrib>Lee, David S. C</creatorcontrib><creatorcontrib>Mitchell, Ian</creatorcontrib><creatorcontrib>Sampalis, John</creatorcontrib><creatorcontrib>Walti, Hervé</creatorcontrib><creatorcontrib>Robinson, Joan</creatorcontrib><creatorcontrib>O’Brien, Karel</creatorcontrib><creatorcontrib>Majaesic, Carina</creatorcontrib><creatorcontrib>Caouette, Georges</creatorcontrib><creatorcontrib>Frenette, Lyne</creatorcontrib><creatorcontrib>Le Saux, Nicole</creatorcontrib><creatorcontrib>Simmons, Brian</creatorcontrib><creatorcontrib>Moisiuk, Sharon</creatorcontrib><creatorcontrib>Sankaran, Koravanagattu</creatorcontrib><creatorcontrib>Ojah, Cecil</creatorcontrib><creatorcontrib>Singh, Avash J</creatorcontrib><creatorcontrib>Lebel, Marc H</creatorcontrib><creatorcontrib>Bacheyie, Godfrey S</creatorcontrib><creatorcontrib>Onyett, Heather</creatorcontrib><creatorcontrib>Michaliszyn, Andrea</creatorcontrib><creatorcontrib>Manzi, Patricia</creatorcontrib><creatorcontrib>Parison, Diana</creatorcontrib><title>The Pediatric Investigators Collaborative Network on Infections in Canada Study of Predictors of Hospitalization for Respiratory Syncytial Virus Infection for Infants Born at 33 Through 35 Completed Weeks of Gestation</title><title>The Pediatric infectious disease journal</title><addtitle>Pediatr Infect Dis J</addtitle><description>BACKGROUND:Infants born at 33 through 35 completed weeks of gestation (33-35GA) are at risk for severe respiratory syncytial virus (RSV) infection, and palivizumab prophylaxis lowers hospitalizations for RSV infection by as much as 80%. The 33-35GA cohort comprises 3-5% of annual births; thus expert panels recommend limiting prophylaxis to situations in which frequency or health care impact of RSV infection is high. This study sought to identify independent risk factors for hospitalization for RSV infection.
METHODS:This was a multicenter, prospective, observational cohort study of 33-35GA infants followed through their first RSV season (2001/2002 or 2002/2003). Baseline data were collected by interview with parents and review of medical records. Respiratory tract illnesses were identified by monthly phone calls, and medical records were reviewed for emergency room visits or hospitalizations. Risk factors were determined by stepwise logistic regression.
RESULTS:Of 1860 enrolled subjects, 1832 (98.5%) were followed for at least 1 month, and 1760 (94.6%) completed all follow-ups. Of 140 (7.6%) subjects hospitalized for respiratory tract illnesses, 66 infants had proven RSV infection. Independent predictors for hospitalization for RSV infection wereday-care attendance (odds ratio, 12.32; 95% confidence interval, 2.56, 59.34); November through January birth (odds ratio, 4.89; 95% confidence interval, 2.57, 9.29); preschool age sibling(s) (odds ratio, 2.76; 95% confidence interval, 1.51, 5.03); birth weight <10th percentile (odds ratio, 2.19; 95% confidence interval, 1.14, 4.22); male gender (odds ratio, 1.91; 95% confidence interval, 1.10, 3.31); ≥2 smokers in the home (odds ratio, 1.87; 95% confidence interval, 1.07, 3.26); and households with >5 people, counting the subject (odds ratio, 1.79; 95% confidence interval, 1.02, 3.16). Family history of eczema (odds ratio, 0.42; 95% confidence interval, 0.18, 0.996) was protective.
CONCLUSIONS:Specific host/environmental factors can be used to identify which 33-35GA infants are at greatest risk of hospitalization for RSV infection and likely to benefit from palivizumab prophylaxis.</description><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Antibodies, Monoclonal, Humanized</subject><subject>Canada - epidemiology</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Multivariate Analysis</subject><subject>Palivizumab</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Prevalence</subject><subject>Probability</subject><subject>Respiratory Syncytial Virus Infections - diagnosis</subject><subject>Respiratory Syncytial Virus Infections - drug therapy</subject><subject>Respiratory Syncytial Virus Infections - epidemiology</subject><subject>Risk Assessment</subject><subject>Severity of Illness Index</subject><subject>Sex Factors</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>0891-3668</issn><issn>1532-0987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkdFu0zAUhi0EYqXwCsjigrtkx3HiJNxBBdukCSZW4NJykpPFNI0721kV3pS3mZtWqm8sH33n_4_PT8gHBjGDMr8EFuuhjSEcxvNMFHHOsqKMq-YFWbCMJxGURf6SLKAoWcSFKC7IG-f-Bp6nDF6TiwAJlrN8Qf6vO6R32Gjlra7pzfCEzusH5Y11dGX6XlXGKq-fkH5Hvzd2Q80QsBZrr83gqB7oSg2qUfTej81ETUvvbNCrZ4XwujZup73q9T916KCtsfQnhpo9mEz0fhrqyWvV09_aju6sPZPhpQbv6BdjB6o85ZyuO2vGh47yLAy43fXosaF_EDez3VWYfzZ6S161qnf47nQvya9vX9er6-j2x9XN6vNtVHMBImLYtgIy5CmkIs0E8JKDyJuaV1XOU17kGQNRNHWbVrzMMEmBVQkgZEnWcFR8ST4edXfWPI7BXW61qzFsbkAzOhnWL4oyrH5JPh3B2hrnLLZyZ_VW2UkykIdgJTAZgpXnYOUcrKya0Pz-5DJWW2zOrackA5Aegb3pPVq36cc9Wtmh6n03S4bfpVECkEKYBqK5xJ8Bd1mzsw</recordid><startdate>200409</startdate><enddate>200409</enddate><creator>Law, Barbara J</creator><creator>Langley, Joanne M</creator><creator>Allen, Upton</creator><creator>Paes, Bosco</creator><creator>Lee, David S. C</creator><creator>Mitchell, Ian</creator><creator>Sampalis, John</creator><creator>Walti, Hervé</creator><creator>Robinson, Joan</creator><creator>O’Brien, Karel</creator><creator>Majaesic, Carina</creator><creator>Caouette, Georges</creator><creator>Frenette, Lyne</creator><creator>Le Saux, Nicole</creator><creator>Simmons, Brian</creator><creator>Moisiuk, Sharon</creator><creator>Sankaran, Koravanagattu</creator><creator>Ojah, Cecil</creator><creator>Singh, Avash J</creator><creator>Lebel, Marc H</creator><creator>Bacheyie, Godfrey S</creator><creator>Onyett, Heather</creator><creator>Michaliszyn, Andrea</creator><creator>Manzi, Patricia</creator><creator>Parison, Diana</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200409</creationdate><title>The Pediatric Investigators Collaborative Network on Infections in Canada Study of Predictors of Hospitalization for Respiratory Syncytial Virus Infection for Infants Born at 33 Through 35 Completed Weeks of Gestation</title><author>Law, Barbara J ; Langley, Joanne M ; Allen, Upton ; Paes, Bosco ; Lee, David S. C ; Mitchell, Ian ; Sampalis, John ; Walti, Hervé ; Robinson, Joan ; O’Brien, Karel ; Majaesic, Carina ; Caouette, Georges ; Frenette, Lyne ; Le Saux, Nicole ; Simmons, Brian ; Moisiuk, Sharon ; Sankaran, Koravanagattu ; Ojah, Cecil ; Singh, Avash J ; Lebel, Marc H ; Bacheyie, Godfrey S ; Onyett, Heather ; Michaliszyn, Andrea ; Manzi, Patricia ; Parison, Diana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3606-1eff605e340464560393067dc3bb73438751068dcf4b395e2401b20e0525d3ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Antibodies, Monoclonal, Humanized</topic><topic>Canada - epidemiology</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Multivariate Analysis</topic><topic>Palivizumab</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Prevalence</topic><topic>Probability</topic><topic>Respiratory Syncytial Virus Infections - diagnosis</topic><topic>Respiratory Syncytial Virus Infections - drug therapy</topic><topic>Respiratory Syncytial Virus Infections - epidemiology</topic><topic>Risk Assessment</topic><topic>Severity of Illness Index</topic><topic>Sex Factors</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Law, Barbara J</creatorcontrib><creatorcontrib>Langley, Joanne M</creatorcontrib><creatorcontrib>Allen, Upton</creatorcontrib><creatorcontrib>Paes, Bosco</creatorcontrib><creatorcontrib>Lee, David S. C</creatorcontrib><creatorcontrib>Mitchell, Ian</creatorcontrib><creatorcontrib>Sampalis, John</creatorcontrib><creatorcontrib>Walti, Hervé</creatorcontrib><creatorcontrib>Robinson, Joan</creatorcontrib><creatorcontrib>O’Brien, Karel</creatorcontrib><creatorcontrib>Majaesic, Carina</creatorcontrib><creatorcontrib>Caouette, Georges</creatorcontrib><creatorcontrib>Frenette, Lyne</creatorcontrib><creatorcontrib>Le Saux, Nicole</creatorcontrib><creatorcontrib>Simmons, Brian</creatorcontrib><creatorcontrib>Moisiuk, Sharon</creatorcontrib><creatorcontrib>Sankaran, Koravanagattu</creatorcontrib><creatorcontrib>Ojah, Cecil</creatorcontrib><creatorcontrib>Singh, Avash J</creatorcontrib><creatorcontrib>Lebel, Marc H</creatorcontrib><creatorcontrib>Bacheyie, Godfrey S</creatorcontrib><creatorcontrib>Onyett, Heather</creatorcontrib><creatorcontrib>Michaliszyn, Andrea</creatorcontrib><creatorcontrib>Manzi, Patricia</creatorcontrib><creatorcontrib>Parison, Diana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Pediatric infectious disease journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Law, Barbara J</au><au>Langley, Joanne M</au><au>Allen, Upton</au><au>Paes, Bosco</au><au>Lee, David S. C</au><au>Mitchell, Ian</au><au>Sampalis, John</au><au>Walti, Hervé</au><au>Robinson, Joan</au><au>O’Brien, Karel</au><au>Majaesic, Carina</au><au>Caouette, Georges</au><au>Frenette, Lyne</au><au>Le Saux, Nicole</au><au>Simmons, Brian</au><au>Moisiuk, Sharon</au><au>Sankaran, Koravanagattu</au><au>Ojah, Cecil</au><au>Singh, Avash J</au><au>Lebel, Marc H</au><au>Bacheyie, Godfrey S</au><au>Onyett, Heather</au><au>Michaliszyn, Andrea</au><au>Manzi, Patricia</au><au>Parison, Diana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Pediatric Investigators Collaborative Network on Infections in Canada Study of Predictors of Hospitalization for Respiratory Syncytial Virus Infection for Infants Born at 33 Through 35 Completed Weeks of Gestation</atitle><jtitle>The Pediatric infectious disease journal</jtitle><addtitle>Pediatr Infect Dis J</addtitle><date>2004-09</date><risdate>2004</risdate><volume>23</volume><issue>9</issue><spage>806</spage><epage>814</epage><pages>806-814</pages><issn>0891-3668</issn><eissn>1532-0987</eissn><abstract>BACKGROUND:Infants born at 33 through 35 completed weeks of gestation (33-35GA) are at risk for severe respiratory syncytial virus (RSV) infection, and palivizumab prophylaxis lowers hospitalizations for RSV infection by as much as 80%. The 33-35GA cohort comprises 3-5% of annual births; thus expert panels recommend limiting prophylaxis to situations in which frequency or health care impact of RSV infection is high. This study sought to identify independent risk factors for hospitalization for RSV infection.
METHODS:This was a multicenter, prospective, observational cohort study of 33-35GA infants followed through their first RSV season (2001/2002 or 2002/2003). Baseline data were collected by interview with parents and review of medical records. Respiratory tract illnesses were identified by monthly phone calls, and medical records were reviewed for emergency room visits or hospitalizations. Risk factors were determined by stepwise logistic regression.
RESULTS:Of 1860 enrolled subjects, 1832 (98.5%) were followed for at least 1 month, and 1760 (94.6%) completed all follow-ups. Of 140 (7.6%) subjects hospitalized for respiratory tract illnesses, 66 infants had proven RSV infection. Independent predictors for hospitalization for RSV infection wereday-care attendance (odds ratio, 12.32; 95% confidence interval, 2.56, 59.34); November through January birth (odds ratio, 4.89; 95% confidence interval, 2.57, 9.29); preschool age sibling(s) (odds ratio, 2.76; 95% confidence interval, 1.51, 5.03); birth weight <10th percentile (odds ratio, 2.19; 95% confidence interval, 1.14, 4.22); male gender (odds ratio, 1.91; 95% confidence interval, 1.10, 3.31); ≥2 smokers in the home (odds ratio, 1.87; 95% confidence interval, 1.07, 3.26); and households with >5 people, counting the subject (odds ratio, 1.79; 95% confidence interval, 1.02, 3.16). Family history of eczema (odds ratio, 0.42; 95% confidence interval, 0.18, 0.996) was protective.
CONCLUSIONS:Specific host/environmental factors can be used to identify which 33-35GA infants are at greatest risk of hospitalization for RSV infection and likely to benefit from palivizumab prophylaxis.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>15361717</pmid><doi>10.1097/01.inf.0000137568.71589.bd</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0891-3668 |
| ispartof | The Pediatric infectious disease journal, 2004-09, Vol.23 (9), p.806-814 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Canada - epidemiology Cohort Studies Female Gestational Age Hospitalization - statistics & numerical data Humans Infant, Newborn Infant, Premature Logistic Models Male Multivariate Analysis Palivizumab Predictive Value of Tests Pregnancy Prevalence Probability Respiratory Syncytial Virus Infections - diagnosis Respiratory Syncytial Virus Infections - drug therapy Respiratory Syncytial Virus Infections - epidemiology Risk Assessment Severity of Illness Index Sex Factors Survival Rate Treatment Outcome |
| title | The Pediatric Investigators Collaborative Network on Infections in Canada Study of Predictors of Hospitalization for Respiratory Syncytial Virus Infection for Infants Born at 33 Through 35 Completed Weeks of Gestation |
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