Influence of maternal tobacco smoking during pregnancy on uterine, umbilical and fetal cerebral artery blood flows
Cigarette smoking during pregnancy is a major cause of adverse perinatal outcome but effects on critical fetal and maternal circulations remain unclear. To determine (1) the influence of habitual maternal cigarette smoking on blood flow velocities in uterine, umbilical and fetal middle cerebral arte...
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| Veröffentlicht in: | Early human development 2004-10, Vol.80 (1), p.31-42 |
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| creator | Albuquerque, Cheryl A. Smith, Karen R. Johnson, Cherie Chao, Rex Harding, Richard |
| description | Cigarette smoking during pregnancy is a major cause of adverse perinatal outcome but effects on critical fetal and maternal circulations remain unclear.
To determine (1) the influence of habitual maternal cigarette smoking on blood flow velocities in uterine, umbilical and fetal middle cerebral arteries, and (2) the time-course of changes in these flows after smoking a cigarette.
In 74 women who smoked and 69 non-smoking controls we measured Doppler blood flow velocity waveforms in the uterine, umbilical and fetal middle cerebral (MCA) arteries; smokers were divided into light (10 cigarettes/day,
n=45).
In the uterine artery there was no significant difference between the systolic/diastolic (S/D) ratio in smoking and non-smoking women; however, in smokers, a diastolic notch was more frequently observed in the uterine artery waveform than in controls (
p |
| doi_str_mv | 10.1016/j.earlhumdev.2004.05.004 |
| format | Article |
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To determine (1) the influence of habitual maternal cigarette smoking on blood flow velocities in uterine, umbilical and fetal middle cerebral arteries, and (2) the time-course of changes in these flows after smoking a cigarette.
In 74 women who smoked and 69 non-smoking controls we measured Doppler blood flow velocity waveforms in the uterine, umbilical and fetal middle cerebral (MCA) arteries; smokers were divided into light (<10 cigarettes/day,
n=28) and heavy smokers (>10 cigarettes/day,
n=45).
In the uterine artery there was no significant difference between the systolic/diastolic (S/D) ratio in smoking and non-smoking women; however, in smokers, a diastolic notch was more frequently observed in the uterine artery waveform than in controls (
p<0.05), suggestive of a greater resistance in the uterine vasculature. In the umbilical artery, the S/D ratio was significantly greater in smokers than in non-smokers. In the fetal MCA, the S/D ratio was higher in heavy smokers than in light smokers (
p<0.05) indicative of greater cerebrovascular resistance. There were no significant correlations between the interval between smoking the last cigarette and making the Doppler measurements and the S/D ratios in any of the vessels.
Maternal cigarette smoking is associated with evidence of chronically increased resistances in the uterine, umbilical and fetal middle cerebral arteries.</description><identifier>ISSN: 0378-3782</identifier><identifier>EISSN: 1872-6232</identifier><identifier>DOI: 10.1016/j.earlhumdev.2004.05.004</identifier><identifier>PMID: 15363837</identifier><identifier>CODEN: EHDEDN</identifier><language>eng</language><publisher>Lausanne: Elsevier Ireland Ltd</publisher><subject>Adult ; Biological and medical sciences ; Blood Flow Velocity - drug effects ; Cerebral Arteries - drug effects ; Cerebral Arteries - physiology ; Cerebral blood flow ; Doppler ; Female ; Fetus ; Fetus - blood supply ; Humans ; Maternal-Fetal Exchange - drug effects ; Medical sciences ; Placenta ; Pregnancy ; Regional Blood Flow - drug effects ; Smoking - adverse effects ; Smoking - physiopathology ; Time Factors ; Tobacco smoking ; Tobacco, tobacco smoking ; Toxicology ; Umbilical Arteries - drug effects ; Umbilical Arteries - physiopathology ; Uterus - blood supply</subject><ispartof>Early human development, 2004-10, Vol.80 (1), p.31-42</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-569fe341913acce0250cf5280481ea21f9315dfa1035a27632e33eee5d60c6b63</citedby><cites>FETCH-LOGICAL-c466t-569fe341913acce0250cf5280481ea21f9315dfa1035a27632e33eee5d60c6b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378378204000805$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16136730$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15363837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Albuquerque, Cheryl A.</creatorcontrib><creatorcontrib>Smith, Karen R.</creatorcontrib><creatorcontrib>Johnson, Cherie</creatorcontrib><creatorcontrib>Chao, Rex</creatorcontrib><creatorcontrib>Harding, Richard</creatorcontrib><title>Influence of maternal tobacco smoking during pregnancy on uterine, umbilical and fetal cerebral artery blood flows</title><title>Early human development</title><addtitle>Early Hum Dev</addtitle><description>Cigarette smoking during pregnancy is a major cause of adverse perinatal outcome but effects on critical fetal and maternal circulations remain unclear.
To determine (1) the influence of habitual maternal cigarette smoking on blood flow velocities in uterine, umbilical and fetal middle cerebral arteries, and (2) the time-course of changes in these flows after smoking a cigarette.
In 74 women who smoked and 69 non-smoking controls we measured Doppler blood flow velocity waveforms in the uterine, umbilical and fetal middle cerebral (MCA) arteries; smokers were divided into light (<10 cigarettes/day,
n=28) and heavy smokers (>10 cigarettes/day,
n=45).
In the uterine artery there was no significant difference between the systolic/diastolic (S/D) ratio in smoking and non-smoking women; however, in smokers, a diastolic notch was more frequently observed in the uterine artery waveform than in controls (
p<0.05), suggestive of a greater resistance in the uterine vasculature. In the umbilical artery, the S/D ratio was significantly greater in smokers than in non-smokers. In the fetal MCA, the S/D ratio was higher in heavy smokers than in light smokers (
p<0.05) indicative of greater cerebrovascular resistance. There were no significant correlations between the interval between smoking the last cigarette and making the Doppler measurements and the S/D ratios in any of the vessels.
Maternal cigarette smoking is associated with evidence of chronically increased resistances in the uterine, umbilical and fetal middle cerebral arteries.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Cerebral Arteries - drug effects</subject><subject>Cerebral Arteries - physiology</subject><subject>Cerebral blood flow</subject><subject>Doppler</subject><subject>Female</subject><subject>Fetus</subject><subject>Fetus - blood supply</subject><subject>Humans</subject><subject>Maternal-Fetal Exchange - drug effects</subject><subject>Medical sciences</subject><subject>Placenta</subject><subject>Pregnancy</subject><subject>Regional Blood Flow - drug effects</subject><subject>Smoking - adverse effects</subject><subject>Smoking - physiopathology</subject><subject>Time Factors</subject><subject>Tobacco smoking</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><subject>Umbilical Arteries - drug effects</subject><subject>Umbilical Arteries - physiopathology</subject><subject>Uterus - blood supply</subject><issn>0378-3782</issn><issn>1872-6232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2PFCEQhonRuLOrf8Fw0ZPdFjDQPUfd-LHJJl70TGi6WBlpGKF7N_PvpTOTzHEP5CXwVFF5IIQyaBkw9WnfosnhzzKN-NhygG0Lsq3xgmxY3_FGccFfkg2Irm_q4lfkupQ9AMh-B6_JFZNCiV50G5LvogsLRos0OTqZGXM0gc5pMNYmWqb018cHOi55jUPGh2iiPdIU6VJZH_EjXabBB29rmYkjdTjXncWMQ16PcsWOdAgp1buQnsob8sqZUPDtOW_I729ff93-aO5_fr-7_Xzf2K1ScyPVzqHYsh0TdRQELsE6yXvY9gwNZ24nmBydYSCk4Z0SHIVARDkqsGpQ4oZ8OPU95PRvwTLryReLIZiIaSlaqV71Xccr2J9Am1MpGZ0-ZD-ZfNQM9Opb7_XFt159a5C6Ri19d35jGSYcL4VnwRV4fwZMqYZcrvZ8uXCKCdUJqNyXE4fVyKPHrIv167eMPqOd9Zj889P8B-wTpSM</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Albuquerque, Cheryl A.</creator><creator>Smith, Karen R.</creator><creator>Johnson, Cherie</creator><creator>Chao, Rex</creator><creator>Harding, Richard</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041001</creationdate><title>Influence of maternal tobacco smoking during pregnancy on uterine, umbilical and fetal cerebral artery blood flows</title><author>Albuquerque, Cheryl A. ; Smith, Karen R. ; Johnson, Cherie ; Chao, Rex ; Harding, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-569fe341913acce0250cf5280481ea21f9315dfa1035a27632e33eee5d60c6b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Cerebral Arteries - drug effects</topic><topic>Cerebral Arteries - physiology</topic><topic>Cerebral blood flow</topic><topic>Doppler</topic><topic>Female</topic><topic>Fetus</topic><topic>Fetus - blood supply</topic><topic>Humans</topic><topic>Maternal-Fetal Exchange - drug effects</topic><topic>Medical sciences</topic><topic>Placenta</topic><topic>Pregnancy</topic><topic>Regional Blood Flow - drug effects</topic><topic>Smoking - adverse effects</topic><topic>Smoking - physiopathology</topic><topic>Time Factors</topic><topic>Tobacco smoking</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><topic>Umbilical Arteries - drug effects</topic><topic>Umbilical Arteries - physiopathology</topic><topic>Uterus - blood supply</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Albuquerque, Cheryl A.</creatorcontrib><creatorcontrib>Smith, Karen R.</creatorcontrib><creatorcontrib>Johnson, Cherie</creatorcontrib><creatorcontrib>Chao, Rex</creatorcontrib><creatorcontrib>Harding, Richard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Early human development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Albuquerque, Cheryl A.</au><au>Smith, Karen R.</au><au>Johnson, Cherie</au><au>Chao, Rex</au><au>Harding, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of maternal tobacco smoking during pregnancy on uterine, umbilical and fetal cerebral artery blood flows</atitle><jtitle>Early human development</jtitle><addtitle>Early Hum Dev</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>80</volume><issue>1</issue><spage>31</spage><epage>42</epage><pages>31-42</pages><issn>0378-3782</issn><eissn>1872-6232</eissn><coden>EHDEDN</coden><abstract>Cigarette smoking during pregnancy is a major cause of adverse perinatal outcome but effects on critical fetal and maternal circulations remain unclear.
To determine (1) the influence of habitual maternal cigarette smoking on blood flow velocities in uterine, umbilical and fetal middle cerebral arteries, and (2) the time-course of changes in these flows after smoking a cigarette.
In 74 women who smoked and 69 non-smoking controls we measured Doppler blood flow velocity waveforms in the uterine, umbilical and fetal middle cerebral (MCA) arteries; smokers were divided into light (<10 cigarettes/day,
n=28) and heavy smokers (>10 cigarettes/day,
n=45).
In the uterine artery there was no significant difference between the systolic/diastolic (S/D) ratio in smoking and non-smoking women; however, in smokers, a diastolic notch was more frequently observed in the uterine artery waveform than in controls (
p<0.05), suggestive of a greater resistance in the uterine vasculature. In the umbilical artery, the S/D ratio was significantly greater in smokers than in non-smokers. In the fetal MCA, the S/D ratio was higher in heavy smokers than in light smokers (
p<0.05) indicative of greater cerebrovascular resistance. There were no significant correlations between the interval between smoking the last cigarette and making the Doppler measurements and the S/D ratios in any of the vessels.
Maternal cigarette smoking is associated with evidence of chronically increased resistances in the uterine, umbilical and fetal middle cerebral arteries.</abstract><cop>Lausanne</cop><cop>New York,NY</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>15363837</pmid><doi>10.1016/j.earlhumdev.2004.05.004</doi><tpages>12</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Blood Flow Velocity - drug effects Cerebral Arteries - drug effects Cerebral Arteries - physiology Cerebral blood flow Doppler Female Fetus Fetus - blood supply Humans Maternal-Fetal Exchange - drug effects Medical sciences Placenta Pregnancy Regional Blood Flow - drug effects Smoking - adverse effects Smoking - physiopathology Time Factors Tobacco smoking Tobacco, tobacco smoking Toxicology Umbilical Arteries - drug effects Umbilical Arteries - physiopathology Uterus - blood supply |
| title | Influence of maternal tobacco smoking during pregnancy on uterine, umbilical and fetal cerebral artery blood flows |
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