Goshuyuto, a Traditional Japanese Medicine, and Aqueous Extracts of Evodiae Fructus Constrict Isolated Rat Aorta via Adrenergic and/or Serotonergic Receptors
Effects of goshuyuto, a traditional Japanese medicine, on vascular constriction were examined using isolated strips of rat aorta. Goshuyuto (1×10−5 to 1×10−3 g/ml) caused constriction of aorta strips in a dose-dependent manner. The vasoconstrictive effects of goshuyuto were significantly inhibited b...
Gespeichert in:
| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2009/02/01, Vol.32(2), pp.237-241 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 241 |
|---|---|
| container_issue | 2 |
| container_start_page | 237 |
| container_title | Biological & Pharmaceutical Bulletin |
| container_volume | 32 |
| creator | Hibino, Tomoko Yuzurihara, Mitsutoshi Kanno, Hitomi Kase, Yoshio Takeda, Atsushi |
| description | Effects of goshuyuto, a traditional Japanese medicine, on vascular constriction were examined using isolated strips of rat aorta. Goshuyuto (1×10−5 to 1×10−3 g/ml) caused constriction of aorta strips in a dose-dependent manner. The vasoconstrictive effects of goshuyuto were significantly inhibited by pretreatment with prazosin, an adrenergic α1 receptor antagonist. The constrictive effects were partially inhibited by pretreatment with BRL15572, a 5-HT1D antagonist, and ketanserin, a 5-HT2A antagonist. However, the constrictive effects were not inhibited by pretreatment with SB216641, a 5-HT1B antagonist, or propranolol, an adrenergic β receptor antagonist. In addition, aqueous extracts of Evodiae Fructus, one of the constituent medicinal herbs of goshuyuto, caused constriction of aorta strips strongly, but aqueous extracts of Zizyphi Fructus, Ginseng Radix, and Zingiberis Rhizoma, the other constituents of goshuyuto, did not have much effect on the vascular response of rat aorta strips. Also, synephrine, which is one of the ingredients of Evodiae Fructus, constricted the rat aorta. These results suggest that goshuyuto constricts rat aorta strips and that the mechanisms involve the adrenergic and/or serotonergic receptors. Also, it may be suggested that Evodiae Fructus and synephrine play the important role in the vasoconstrictive effects of goshuyuto on rat aorta strips. |
| doi_str_mv | 10.1248/bpb.32.237 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66868335</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3121436641</sourcerecordid><originalsourceid>FETCH-LOGICAL-c618t-b2e883c576f6117bc0e563b87bc13545a0dffeed6029aaf406d420de169916783</originalsourceid><addsrcrecordid>eNpdkc9u1DAQxiMEokvhwgMgS0gcENn6T2I7J7Ra7ZaiIqRSzpZjT1qvsnGwnYo-TN-1XmVpJS5ja-bnbzzzFcV7gpeEVvKsHdslo0vKxItiQVglypqS-mWxwA2RJSe1PCnexLjDGAtM2evihOQCZZIuiodzH2-n-yn5L0ij66CtS84Pukff9agHiIB-gHXGDZCBwaLVnwn8FNHmbwrapIh8hzZ33joNaBsmk3Jt7YeYgjMJXUTf6wQWXemEVj4kje6cRisbYIBw48xB88wH9AuCT_6YuwIDY_Ihvi1edbqP8O54nha_t5vr9bfy8uf5xXp1WRpOZCpbClIyUwvecUJEazDUnLUy3wirq1pj23UAlmPaaN1VmNuKYguENw3hQrLT4tOsOwaf54tJ7V000Pd5A3lYxbnkkrE6gx__A3d-CnldUZGqaphgjPJMfZ4pE3yMATo1BrfX4V4RrA6WqWyZYlRlyzL84Sg5tXuwz-jRowxsZ2B_MEL3fuizG8-NTRSt871XFONGYcwopgqTSmWvRQ4VoYJKzLLQ11loF5O-gadOOiRnenj61BwOj_9VzK0OCgb2CFU7v_c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1449373326</pqid></control><display><type>article</type><title>Goshuyuto, a Traditional Japanese Medicine, and Aqueous Extracts of Evodiae Fructus Constrict Isolated Rat Aorta via Adrenergic and/or Serotonergic Receptors</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Hibino, Tomoko ; Yuzurihara, Mitsutoshi ; Kanno, Hitomi ; Kase, Yoshio ; Takeda, Atsushi</creator><creatorcontrib>Hibino, Tomoko ; Yuzurihara, Mitsutoshi ; Kanno, Hitomi ; Kase, Yoshio ; Takeda, Atsushi ; School of Pharmaceutical Sciences ; aTsumura Research Laboratories ; Tsumura & Co ; bDepartment of Medical Biochemistry ; University of Shizuoka</creatorcontrib><description>Effects of goshuyuto, a traditional Japanese medicine, on vascular constriction were examined using isolated strips of rat aorta. Goshuyuto (1×10−5 to 1×10−3 g/ml) caused constriction of aorta strips in a dose-dependent manner. The vasoconstrictive effects of goshuyuto were significantly inhibited by pretreatment with prazosin, an adrenergic α1 receptor antagonist. The constrictive effects were partially inhibited by pretreatment with BRL15572, a 5-HT1D antagonist, and ketanserin, a 5-HT2A antagonist. However, the constrictive effects were not inhibited by pretreatment with SB216641, a 5-HT1B antagonist, or propranolol, an adrenergic β receptor antagonist. In addition, aqueous extracts of Evodiae Fructus, one of the constituent medicinal herbs of goshuyuto, caused constriction of aorta strips strongly, but aqueous extracts of Zizyphi Fructus, Ginseng Radix, and Zingiberis Rhizoma, the other constituents of goshuyuto, did not have much effect on the vascular response of rat aorta strips. Also, synephrine, which is one of the ingredients of Evodiae Fructus, constricted the rat aorta. These results suggest that goshuyuto constricts rat aorta strips and that the mechanisms involve the adrenergic and/or serotonergic receptors. Also, it may be suggested that Evodiae Fructus and synephrine play the important role in the vasoconstrictive effects of goshuyuto on rat aorta strips.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.32.237</identifier><identifier>PMID: 19182382</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>5-HT1D ; 5-HT2A ; Adrenergic alpha-Antagonists - pharmacology ; Adrenergic beta-Antagonists - pharmacology ; adrenergic α1 ; Animals ; Aorta, Thoracic - drug effects ; Dose-Response Relationship, Drug ; Evodia - chemistry ; Evodiae Fructus ; goshuyuto ; In Vitro Techniques ; Indicators and Reagents ; Muscle, Smooth, Vascular - drug effects ; Plant Extracts - pharmacology ; Rats ; Rats, Wistar ; Receptors, Adrenergic - drug effects ; Receptors, Serotonin - drug effects ; Serotonin Antagonists - pharmacology ; synephrine ; Vasoconstrictor Agents - pharmacology ; Vasodilator Agents</subject><ispartof>Biological and Pharmaceutical Bulletin, 2009/02/01, Vol.32(2), pp.237-241</ispartof><rights>2009 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c618t-b2e883c576f6117bc0e563b87bc13545a0dffeed6029aaf406d420de169916783</citedby><cites>FETCH-LOGICAL-c618t-b2e883c576f6117bc0e563b87bc13545a0dffeed6029aaf406d420de169916783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19182382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hibino, Tomoko</creatorcontrib><creatorcontrib>Yuzurihara, Mitsutoshi</creatorcontrib><creatorcontrib>Kanno, Hitomi</creatorcontrib><creatorcontrib>Kase, Yoshio</creatorcontrib><creatorcontrib>Takeda, Atsushi</creatorcontrib><creatorcontrib>School of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>aTsumura Research Laboratories</creatorcontrib><creatorcontrib>Tsumura & Co</creatorcontrib><creatorcontrib>bDepartment of Medical Biochemistry</creatorcontrib><creatorcontrib>University of Shizuoka</creatorcontrib><title>Goshuyuto, a Traditional Japanese Medicine, and Aqueous Extracts of Evodiae Fructus Constrict Isolated Rat Aorta via Adrenergic and/or Serotonergic Receptors</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Effects of goshuyuto, a traditional Japanese medicine, on vascular constriction were examined using isolated strips of rat aorta. Goshuyuto (1×10−5 to 1×10−3 g/ml) caused constriction of aorta strips in a dose-dependent manner. The vasoconstrictive effects of goshuyuto were significantly inhibited by pretreatment with prazosin, an adrenergic α1 receptor antagonist. The constrictive effects were partially inhibited by pretreatment with BRL15572, a 5-HT1D antagonist, and ketanserin, a 5-HT2A antagonist. However, the constrictive effects were not inhibited by pretreatment with SB216641, a 5-HT1B antagonist, or propranolol, an adrenergic β receptor antagonist. In addition, aqueous extracts of Evodiae Fructus, one of the constituent medicinal herbs of goshuyuto, caused constriction of aorta strips strongly, but aqueous extracts of Zizyphi Fructus, Ginseng Radix, and Zingiberis Rhizoma, the other constituents of goshuyuto, did not have much effect on the vascular response of rat aorta strips. Also, synephrine, which is one of the ingredients of Evodiae Fructus, constricted the rat aorta. These results suggest that goshuyuto constricts rat aorta strips and that the mechanisms involve the adrenergic and/or serotonergic receptors. Also, it may be suggested that Evodiae Fructus and synephrine play the important role in the vasoconstrictive effects of goshuyuto on rat aorta strips.</description><subject>5-HT1D</subject><subject>5-HT2A</subject><subject>Adrenergic alpha-Antagonists - pharmacology</subject><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>adrenergic α1</subject><subject>Animals</subject><subject>Aorta, Thoracic - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Evodia - chemistry</subject><subject>Evodiae Fructus</subject><subject>goshuyuto</subject><subject>In Vitro Techniques</subject><subject>Indicators and Reagents</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Adrenergic - drug effects</subject><subject>Receptors, Serotonin - drug effects</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>synephrine</subject><subject>Vasoconstrictor Agents - pharmacology</subject><subject>Vasodilator Agents</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc9u1DAQxiMEokvhwgMgS0gcENn6T2I7J7Ra7ZaiIqRSzpZjT1qvsnGwnYo-TN-1XmVpJS5ja-bnbzzzFcV7gpeEVvKsHdslo0vKxItiQVglypqS-mWxwA2RJSe1PCnexLjDGAtM2evihOQCZZIuiodzH2-n-yn5L0ij66CtS84Pukff9agHiIB-gHXGDZCBwaLVnwn8FNHmbwrapIh8hzZ33joNaBsmk3Jt7YeYgjMJXUTf6wQWXemEVj4kje6cRisbYIBw48xB88wH9AuCT_6YuwIDY_Ihvi1edbqP8O54nha_t5vr9bfy8uf5xXp1WRpOZCpbClIyUwvecUJEazDUnLUy3wirq1pj23UAlmPaaN1VmNuKYguENw3hQrLT4tOsOwaf54tJ7V000Pd5A3lYxbnkkrE6gx__A3d-CnldUZGqaphgjPJMfZ4pE3yMATo1BrfX4V4RrA6WqWyZYlRlyzL84Sg5tXuwz-jRowxsZ2B_MEL3fuizG8-NTRSt871XFONGYcwopgqTSmWvRQ4VoYJKzLLQ11loF5O-gadOOiRnenj61BwOj_9VzK0OCgb2CFU7v_c</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Hibino, Tomoko</creator><creator>Yuzurihara, Mitsutoshi</creator><creator>Kanno, Hitomi</creator><creator>Kase, Yoshio</creator><creator>Takeda, Atsushi</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>Goshuyuto, a Traditional Japanese Medicine, and Aqueous Extracts of Evodiae Fructus Constrict Isolated Rat Aorta via Adrenergic and/or Serotonergic Receptors</title><author>Hibino, Tomoko ; Yuzurihara, Mitsutoshi ; Kanno, Hitomi ; Kase, Yoshio ; Takeda, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c618t-b2e883c576f6117bc0e563b87bc13545a0dffeed6029aaf406d420de169916783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>5-HT1D</topic><topic>5-HT2A</topic><topic>Adrenergic alpha-Antagonists - pharmacology</topic><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>adrenergic α1</topic><topic>Animals</topic><topic>Aorta, Thoracic - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Evodia - chemistry</topic><topic>Evodiae Fructus</topic><topic>goshuyuto</topic><topic>In Vitro Techniques</topic><topic>Indicators and Reagents</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Adrenergic - drug effects</topic><topic>Receptors, Serotonin - drug effects</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>synephrine</topic><topic>Vasoconstrictor Agents - pharmacology</topic><topic>Vasodilator Agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hibino, Tomoko</creatorcontrib><creatorcontrib>Yuzurihara, Mitsutoshi</creatorcontrib><creatorcontrib>Kanno, Hitomi</creatorcontrib><creatorcontrib>Kase, Yoshio</creatorcontrib><creatorcontrib>Takeda, Atsushi</creatorcontrib><creatorcontrib>School of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>aTsumura Research Laboratories</creatorcontrib><creatorcontrib>Tsumura & Co</creatorcontrib><creatorcontrib>bDepartment of Medical Biochemistry</creatorcontrib><creatorcontrib>University of Shizuoka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hibino, Tomoko</au><au>Yuzurihara, Mitsutoshi</au><au>Kanno, Hitomi</au><au>Kase, Yoshio</au><au>Takeda, Atsushi</au><aucorp>School of Pharmaceutical Sciences</aucorp><aucorp>aTsumura Research Laboratories</aucorp><aucorp>Tsumura & Co</aucorp><aucorp>bDepartment of Medical Biochemistry</aucorp><aucorp>University of Shizuoka</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Goshuyuto, a Traditional Japanese Medicine, and Aqueous Extracts of Evodiae Fructus Constrict Isolated Rat Aorta via Adrenergic and/or Serotonergic Receptors</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>32</volume><issue>2</issue><spage>237</spage><epage>241</epage><pages>237-241</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Effects of goshuyuto, a traditional Japanese medicine, on vascular constriction were examined using isolated strips of rat aorta. Goshuyuto (1×10−5 to 1×10−3 g/ml) caused constriction of aorta strips in a dose-dependent manner. The vasoconstrictive effects of goshuyuto were significantly inhibited by pretreatment with prazosin, an adrenergic α1 receptor antagonist. The constrictive effects were partially inhibited by pretreatment with BRL15572, a 5-HT1D antagonist, and ketanserin, a 5-HT2A antagonist. However, the constrictive effects were not inhibited by pretreatment with SB216641, a 5-HT1B antagonist, or propranolol, an adrenergic β receptor antagonist. In addition, aqueous extracts of Evodiae Fructus, one of the constituent medicinal herbs of goshuyuto, caused constriction of aorta strips strongly, but aqueous extracts of Zizyphi Fructus, Ginseng Radix, and Zingiberis Rhizoma, the other constituents of goshuyuto, did not have much effect on the vascular response of rat aorta strips. Also, synephrine, which is one of the ingredients of Evodiae Fructus, constricted the rat aorta. These results suggest that goshuyuto constricts rat aorta strips and that the mechanisms involve the adrenergic and/or serotonergic receptors. Also, it may be suggested that Evodiae Fructus and synephrine play the important role in the vasoconstrictive effects of goshuyuto on rat aorta strips.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>19182382</pmid><doi>10.1248/bpb.32.237</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 2009/02/01, Vol.32(2), pp.237-241 |
| issn | 0918-6158 1347-5215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66868335 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | 5-HT1D 5-HT2A Adrenergic alpha-Antagonists - pharmacology Adrenergic beta-Antagonists - pharmacology adrenergic α1 Animals Aorta, Thoracic - drug effects Dose-Response Relationship, Drug Evodia - chemistry Evodiae Fructus goshuyuto In Vitro Techniques Indicators and Reagents Muscle, Smooth, Vascular - drug effects Plant Extracts - pharmacology Rats Rats, Wistar Receptors, Adrenergic - drug effects Receptors, Serotonin - drug effects Serotonin Antagonists - pharmacology synephrine Vasoconstrictor Agents - pharmacology Vasodilator Agents |
| title | Goshuyuto, a Traditional Japanese Medicine, and Aqueous Extracts of Evodiae Fructus Constrict Isolated Rat Aorta via Adrenergic and/or Serotonergic Receptors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T14%3A54%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Goshuyuto,%20a%20Traditional%20Japanese%20Medicine,%20and%20Aqueous%20Extracts%20of%20Evodiae%20Fructus%20Constrict%20Isolated%20Rat%20Aorta%20via%20Adrenergic%20and/or%20Serotonergic%20Receptors&rft.jtitle=Biological%20&%20Pharmaceutical%20Bulletin&rft.au=Hibino,%20Tomoko&rft.aucorp=School%20of%20Pharmaceutical%20Sciences&rft.date=2009-02-01&rft.volume=32&rft.issue=2&rft.spage=237&rft.epage=241&rft.pages=237-241&rft.issn=0918-6158&rft.eissn=1347-5215&rft_id=info:doi/10.1248/bpb.32.237&rft_dat=%3Cproquest_cross%3E3121436641%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1449373326&rft_id=info:pmid/19182382&rfr_iscdi=true |