Negative Regulation of Phosphatidylinositol 4,5-Bisphosphate Levels by the INP51-associated Proteins TAX4 and IRS4

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is an important second messenger in signaling pathways in organisms ranging from yeast to mammals, but the regulation of PI(4,5)P2 levels remains unclear. Here we present evidence that PI(4,5)P2 levels in Saccharomyces cerevisiae are down-regulated b...

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Veröffentlicht in:	The Journal of biological chemistry 2004-09, Vol.279 (38), p.39604-39610
Hauptverfasser:	Morales-Johansson, Helena, Jenoe, Paul, Cooke, Frank T., Hall, Michael N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins Chitin - metabolism Down-Regulation Mitogen-Activated Protein Kinases - metabolism Mutation Phosphatidylinositol 3-Kinases Phosphatidylinositol 4,5-Diphosphate - metabolism Phosphoric Monoester Hydrolases - metabolism Phosphotransferases (Alcohol Group Acceptor) - genetics Protein Structure, Tertiary Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae Proteins - metabolism Signal Transduction - physiology
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