In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E(2) biosynthesis

Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E(2) catalysed by COX-2 with an IC(50) value of 0.8 microM what is practically the same concentration as the IC(50) obtained for the standard inhib...

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Veröffentlicht in:	Archives of pharmacal research 2009-01, Vol.32 (1), p.75-78
Hauptverfasser:	Landa, Premysl, Kokoska, Ladislav, Pribylova, Marie, Vanek, Tomas, Marsik, Petr
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Dinoprostone - biosynthesis Dose-Response Relationship, Drug Indomethacin - pharmacology Monoterpenes - pharmacology Nitrobenzenes - pharmacology Sheep Sulfonamides - pharmacology
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