Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity

We previously reported that phosphorylation of topoisomerase (topo) IIalpha at serine-1106 (Ser-1106) regulates enzyme activity and sensitivity to topo II-targeted drugs. In this study we demonstrate that phosphorylation of Ser-1106, which is flanked by acidic amino acids, is regulated in vivo by ca...

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Veröffentlicht in:	Nucleic acids research 2009-02, Vol.37 (2), p.382-392
Hauptverfasser:	Grozav, Adrian G, Chikamori, Kenichi, Kozuki, Toshiyuki, Grabowski, Dale R, Bukowski, Ronald M, Willard, Belinda, Kinter, Michael, Andersen, Anni H, Ganapathi, Ram, Ganapathi, Mahrukh K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - chemistry Antigens, Neoplasm - metabolism Casein Kinase I - genetics Casein Kinase Idelta - antagonists & inhibitors Casein Kinase Idelta - metabolism Casein Kinase Iepsilon - antagonists & inhibitors Casein Kinase Iepsilon - genetics Casein Kinase Iepsilon - metabolism DNA Cleavage DNA Topoisomerases, Type II - chemistry DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Down-Regulation Etoposide - pharmacology HL-60 Cells Humans Peptides - chemistry Peptides - metabolism Phosphorylation Protein Kinase Inhibitors - pharmacology RNA Interference Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Serine - metabolism Transformation, Genetic
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