miR-133 and miR-30 Regulate Connective Tissue Growth Factor: Implications for a Role of MicroRNAs in Myocardial Matrix Remodeling

The myocardium of the failing heart undergoes a number of structural alterations, most notably hypertrophy of cardiac myocytes and an increase in extracellular matrix proteins, often seen as primary fibrosis. Connective tissue growth factor (CTGF) is a key molecule in the process of fibrosis and the...

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Veröffentlicht in:	Circulation research 2009-01, Vol.104 (2), p.170-178
Hauptverfasser:	Duisters, Rudy F, Tijsen, Anke J, Schroen, Blanche, Leenders, Joost J, Lentink, Viola, van der Made, Ingeborg, Herias, Veronica, van Leeuwen, Rick E, Schellings, Mark W, Barenbrug, Paul, Maessen, Jos G, Heymans, Stephane, Pinto, Yigal M, Creemers, Esther E
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Animals, Newborn Base Sequence Biological and medical sciences Cardiology. Vascular system Cells, Cultured Computational Biology Connective Tissue Growth Factor - genetics Connective Tissue Growth Factor - metabolism Disease Models, Animal Extracellular Matrix - metabolism Female Fibrosis Fundamental and applied biological sciences. Psychology Gene Knockdown Techniques Heart Heart Failure - genetics Heart Failure - metabolism Heart Failure - pathology Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Hypertrophy, Left Ventricular - genetics Hypertrophy, Left Ventricular - metabolism Hypertrophy, Left Ventricular - pathology Male Medical sciences Mice Mice, Inbred C57BL MicroRNAs - metabolism Molecular Sequence Data Myocardium - metabolism Myocardium - pathology Phylogeny Rats Rats, Sprague-Dawley Rats, Transgenic Renin - genetics Renin - metabolism RNA Processing, Post-Transcriptional RNA, Messenger - metabolism Up-Regulation Ventricular Remodeling - genetics Vertebrates: cardiovascular system
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