Synthesis of Novel Biodegradable Cationic Polymer: N,N-Diethylethylenediamine Polyurethane as a Gene Carrier

A new cationic polymer, N,N-diethylethylenediamine-polyurethane (DEDA-PU), bearing tertiary amines in the backbone and side chains, was synthesized and used as a nonviral vector for gene delivery. The DEDA-PU readily self-assembled with the plasmid DNA (pCMV-βgal) in water and buffer at physiologica...

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Veröffentlicht in:	Biomacromolecules 2004-09, Vol.5 (5), p.1926-1932
Hauptverfasser:	Yang, Tsung-fu, Chin, Wei-kuo, Cherng, Jong-yuh, Shau, Min-da
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Biological and medical sciences Cations Cell Line Ethylenediamines - administration & dosage Ethylenediamines - chemical synthesis Ethylenediamines - metabolism Exact sciences and technology Gene Targeting - methods General pharmacology Humans Medical sciences Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polymers - administration & dosage Polymers - chemical synthesis Polymers - metabolism Polymers with particular properties Polyurethanes - administration & dosage Polyurethanes - chemical synthesis Polyurethanes - metabolism Preparation, kinetics, thermodynamics, mechanism and catalysts Transfection - methods
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