Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity

The role of nitric oxide (NO) in inflammatory bowel diseases has traditionally focused on the inducible form of NO synthase (iNOS). However, the constitutive endothelial (eNOS) and neuronal (nNOS) isoforms may also impact on colitis, either by contributing to the inflammation or by regulating mucosa...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2004-10, Vol.287 (4), p.G865-G874
Hauptverfasser:	Vallance, Bruce A, Dijkstra, Gerard, Qiu, Bosheng, van der Waaij, Laurens A, van Goor, Harry, Jansen, Peter L M, Mashimo, Hiroshi, Collins, Stephen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Translocation Colitis - immunology Colitis - metabolism Colitis - physiopathology Goblet Cells - enzymology Goblet Cells - ultrastructure Intestinal Mucosa - cytology Intestinal Mucosa - enzymology Male Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Electron Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type I Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Specific Pathogen-Free Organisms Tyrosine - analogs & derivatives Tyrosine - metabolism
Online-Zugang:	Volltext
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