Developmental biology of the pancreas: A comprehensive review
Pancreatic development represents a fascinating process in which two morphologically distinct tissue types must derive from one simple epithelium. These two tissue types, exocrine (including acinar cells, centro-acinar cells, and ducts) and endocrine cells serve disparate functions, and have entirel...
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| Veröffentlicht in: | Developmental biology 2009-02, Vol.326 (1), p.4-35 |
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| container_title | Developmental biology |
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| creator | Gittes, George K. |
| description | Pancreatic development represents a fascinating process in which two morphologically distinct tissue types must derive from one simple epithelium. These two tissue types, exocrine (including acinar cells, centro-acinar cells, and ducts) and endocrine cells serve disparate functions, and have entirely different morphology. In addition, the endocrine tissue must become disconnected from the epithelial lining during its development. The pancreatic development field has exploded in recent years, and numerous published reviews have dealt specifically with only recent findings, or specifically with certain aspects of pancreatic development. Here I wish to present a more comprehensive review of all aspects of pancreatic development, though still there is not a room for discussion of stem cell differentiation to pancreas, nor for discussion of post-natal regeneration phenomena, two important fields closely related to pancreatic development. |
| doi_str_mv | 10.1016/j.ydbio.2008.10.024 |
| format | Article |
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| ispartof | Developmental biology, 2009-02, Vol.326 (1), p.4-35 |
| issn | 0012-1606 1095-564X |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Antigens, Differentiation - metabolism Blood Vessels - cytology Blood Vessels - embryology Blood Vessels - metabolism Cell Differentiation - physiology Cell Lineage - physiology Endothelium, Vascular - cytology Endothelium, Vascular - embryology Endothelium, Vascular - metabolism Epithelium - embryology Epithelium - metabolism Extracellular Matrix - physiology Humans Mesoderm - blood supply Mesoderm - embryology Mesoderm - metabolism Notochord - cytology Notochord - embryology Notochord - metabolism Pancreas - cytology Pancreas - embryology Pancreas - metabolism Signal Transduction - physiology |
| title | Developmental biology of the pancreas: A comprehensive review |
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