Differential Requirements for DOCK2 and Phosphoinositide-3-Kinase γ during T and B Lymphocyte Homing

Chemokines guide lymphocytes from blood to secondary lymphoid organs by triggering integrin-dependent firm adhesion under vascular flow and directed migration of T and B lymphocytes within lymphoid tissue. Here, we analyze the roles of DOCK2, a mammalian homolog of Caenorhabditis elegans CED-5 and D...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2004-09, Vol.21 (3), p.429-441
Hauptverfasser:	Nombela-Arrieta, César, Lacalle, Rosa Ana, Montoya, Marı́a C., Kunisaki, Yuya, Megı́as, Diego, Marqués, Miriam, Carrera, Ana C., Mañes, Santos, Fukui, Yoshinori, Martı́nez-A, Carlos, Stein, Jens V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals B-Lymphocytes - immunology B-Lymphocytes - metabolism Caenorhabditis elegans Cell Adhesion - immunology Cell Movement - immunology Cells, Cultured Drosophila melanogaster Fluorescent Antibody Technique GTPase-Activating Proteins - immunology GTPase-Activating Proteins - metabolism Immunoblotting Immunohistochemistry Integrins - metabolism Lymphocyte Activation - immunology Lymphoid Tissue - immunology Mice Phosphatidylinositol 3-Kinases - immunology Phosphatidylinositol 3-Kinases - metabolism Signal Transduction - immunology T-Lymphocytes - immunology T-Lymphocytes - metabolism
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