Liquid chromatography-electrospray tandem mass spectrometric assay suitable for quantitation of halofuginone in plasma

An LC-MS/MS method was developed to quantitate the potential antitumor agent halofuginone in plasma. The assay uses 0.2 ml of plasma; chlorohalofuginone internal standard; acetonitrile for protein precipitation; a Phenomenex SYNERGI 4 micro Polar RP 80A (4 microm, 100 mm x 2 mm) column; an isocratic...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2004-10, Vol.810 (1), p.35-40
Hauptverfasser:	PARISE, Robert A, SPARROW, Barney R, MERRILL, John W, GROSSI, Irnla M, COVEY, Joseph M, PEGGINS, James O, EGORIN, Menill J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromatography, Liquid Coccidiostats - blood Coccidiostats - pharmacokinetics Dogs Fundamental and applied biological sciences. Psychology General pharmacology Indicators and Reagents Mass Spectrometry Medical sciences Molecular Weight Pharmacology. Drug treatments Piperidines Quinazolines - blood Quinazolines - pharmacokinetics Quinazolinones Reference Standards Reproducibility of Results Spectrometry, Mass, Electrospray Ionization
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