Molecular cloning and characterization of a 2-deoxystreptamine biosynthetic gene cluster in gentamicin-producing Micromonospora echinospora ATCC15835

The organization of the 2-deoxystreptamine (DOS) biosynthetic gene cluster of Micromonospora echinospora has been determined. Sequencing of a 14.04 kb-region revealed twelve open reading frames (ORFs): four putative DOS biosynthetic genes (gtmA, B, C, and D), five amino sugars biosynthetic genes (gt...

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Veröffentlicht in:	Molecules and cells 2004-08, Vol.18 (1), p.71-78
Hauptverfasser:	Kharel, Madan K, Basnet, Devi B, Lee, Hei Chan, Liou, Kwangkyoung, Moon, Young Ho, Kim, Jae-Jong, Woo, Jin Suk, Sohng, Jae Kyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Cloning, Molecular Drug Resistance, Bacterial Gentamicins - biosynthesis Gentamicins - chemistry Glucose-6-Phosphate - metabolism Hexosamines - chemistry Hexosamines - genetics Hexosamines - metabolism Micromonospora - genetics Micromonospora - metabolism Molecular Structure Multigene Family Open Reading Frames Sequence Analysis, DNA
Online-Zugang:	Volltext
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