Turning off signal transducer and activator of transcription (STAT): The negative regulation of STAT signaling
Signal transducer and activator of transcription (STAT) proteins are a group of transcription factors that transmit signals from the extracellular milieu of cells to the nucleus. They are crucial for the signaling of many cytokines that are mediators of allergic inflammation. Considerable informatio...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2004-09, Vol.114 (3), p.476-489 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Chen, Weiguo Daines, Michael O. Khurana Hershey, Gurjit K. |
| description | Signal transducer and activator of transcription (STAT) proteins are a group of transcription factors that transmit signals from the extracellular milieu of cells to the nucleus. They are crucial for the signaling of many cytokines that are mediators of allergic inflammation. Considerable information is known about the activation of STATs and their role in gene transcription; comparably much less is known about how STAT signaling is regulated. Because STATs are critical for the induction of many genes crucial for the allergic cascade and immune host defense, understanding the regulation of these molecules will provide novel insights into allergic and immunodeficiency disorders and will likely identify new targets for therapeutic interventions. This review will summarize the current understanding of the regulation of STAT signaling, emphasizing recent observations. |
| doi_str_mv | 10.1016/j.jaci.2004.06.042 |
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They are crucial for the signaling of many cytokines that are mediators of allergic inflammation. Considerable information is known about the activation of STATs and their role in gene transcription; comparably much less is known about how STAT signaling is regulated. Because STATs are critical for the induction of many genes crucial for the allergic cascade and immune host defense, understanding the regulation of these molecules will provide novel insights into allergic and immunodeficiency disorders and will likely identify new targets for therapeutic interventions. This review will summarize the current understanding of the regulation of STAT signaling, emphasizing recent observations.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2004.06.042</identifier><identifier>PMID: 15356544</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Animals ; Biological and medical sciences ; Cytokine ; Cytokines ; DNA-Binding Proteins - metabolism ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gene Expression Regulation ; Genes ; Humans ; Hypersensitivity - immunology ; Hypersensitivity - physiopathology ; Immune system ; Immunologic Deficiency Syndromes - immunology ; Immunologic Deficiency Syndromes - physiopathology ; Immunopathology ; Jak-STAT ; Kinases ; Medical sciences ; methylation ; Mice ; Mice, SCID ; Mutation ; phosphatase ; protein inhibitor of activated STAT ; Protein-Tyrosine Kinases - metabolism ; review ; Signal Transduction ; STAT ; suppressor of cytokine signaling ; Trans-Activators - metabolism</subject><ispartof>Journal of allergy and clinical immunology, 2004-09, Vol.114 (3), p.476-489</ispartof><rights>2004 American Academy of Allergy, Asthma and Immunology</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Elsevier Limited Sep 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-c0deccbaaf602a76788df47230e0d5a76472e4ce038cf524a0308cb5647d7f3a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2004.06.042$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16108770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15356544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Weiguo</creatorcontrib><creatorcontrib>Daines, Michael O.</creatorcontrib><creatorcontrib>Khurana Hershey, Gurjit K.</creatorcontrib><title>Turning off signal transducer and activator of transcription (STAT): The negative regulation of STAT signaling</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Signal transducer and activator of transcription (STAT) proteins are a group of transcription factors that transmit signals from the extracellular milieu of cells to the nucleus. They are crucial for the signaling of many cytokines that are mediators of allergic inflammation. Considerable information is known about the activation of STATs and their role in gene transcription; comparably much less is known about how STAT signaling is regulated. Because STATs are critical for the induction of many genes crucial for the allergic cascade and immune host defense, understanding the regulation of these molecules will provide novel insights into allergic and immunodeficiency disorders and will likely identify new targets for therapeutic interventions. This review will summarize the current understanding of the regulation of STAT signaling, emphasizing recent observations.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cytokine</subject><subject>Cytokines</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gene Expression Regulation</subject><subject>Genes</subject><subject>Humans</subject><subject>Hypersensitivity - immunology</subject><subject>Hypersensitivity - physiopathology</subject><subject>Immune system</subject><subject>Immunologic Deficiency Syndromes - immunology</subject><subject>Immunologic Deficiency Syndromes - physiopathology</subject><subject>Immunopathology</subject><subject>Jak-STAT</subject><subject>Kinases</subject><subject>Medical sciences</subject><subject>methylation</subject><subject>Mice</subject><subject>Mice, SCID</subject><subject>Mutation</subject><subject>phosphatase</subject><subject>protein inhibitor of activated STAT</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>review</subject><subject>Signal Transduction</subject><subject>STAT</subject><subject>suppressor of cytokine signaling</subject><subject>Trans-Activators - metabolism</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV2L1TAQhoMo7nH1D3ghBVH0onXSfHbxZln8ggUvrNchJ50eU3rSY9Iu-O9NPYUFL_Qqycwz70zmJeQ5hYoCle-GarDOVzUAr0BWwOsHZEehUaXUtXhIdgANLaXizQV5ktIA-c1085hcUMGEFJzvSGiXGHw4FFPfF8kfgh2LOdqQusVhLGzoCutmf2fnKWbmnHPRn2Y_heLNt_a6fXtVtD-wCHiwGcQi4mEZ7Z98LliJTTi3eUoe9XZM-Gw7L8n3jx_am8_l7ddPX26ub0snQM2lgw6d21vbS6itkkrrrueqZoDQiRzId-QOgWnXi5pbYKDdXuR4p3pm2SV5fdY9xenngmk2R58cjqMNOC3JSKll3ob6L0iVqBvKmgy-_Ascpry6_AlDBXDNNGsgU_WZcnFKKWJvTtEfbfxlKJjVNDOY1TSzmmZAmmxaLnqxSS_7I3b3JZtLGXi1ATY5O_bZA-fTPScpaKXW7u_PHObV3nmMJjmPwWHnI7rZdJP_1xy_AT7dtJM</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Chen, Weiguo</creator><creator>Daines, Michael O.</creator><creator>Khurana Hershey, Gurjit K.</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Turning off signal transducer and activator of transcription (STAT): The negative regulation of STAT signaling</title><author>Chen, Weiguo ; Daines, Michael O. ; Khurana Hershey, Gurjit K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-c0deccbaaf602a76788df47230e0d5a76472e4ce038cf524a0308cb5647d7f3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cytokine</topic><topic>Cytokines</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gene Expression Regulation</topic><topic>Genes</topic><topic>Humans</topic><topic>Hypersensitivity - immunology</topic><topic>Hypersensitivity - physiopathology</topic><topic>Immune system</topic><topic>Immunologic Deficiency Syndromes - immunology</topic><topic>Immunologic Deficiency Syndromes - physiopathology</topic><topic>Immunopathology</topic><topic>Jak-STAT</topic><topic>Kinases</topic><topic>Medical sciences</topic><topic>methylation</topic><topic>Mice</topic><topic>Mice, SCID</topic><topic>Mutation</topic><topic>phosphatase</topic><topic>protein inhibitor of activated STAT</topic><topic>Protein-Tyrosine Kinases - metabolism</topic><topic>review</topic><topic>Signal Transduction</topic><topic>STAT</topic><topic>suppressor of cytokine signaling</topic><topic>Trans-Activators - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Weiguo</creatorcontrib><creatorcontrib>Daines, Michael O.</creatorcontrib><creatorcontrib>Khurana Hershey, Gurjit K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Weiguo</au><au>Daines, Michael O.</au><au>Khurana Hershey, Gurjit K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Turning off signal transducer and activator of transcription (STAT): The negative regulation of STAT signaling</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>114</volume><issue>3</issue><spage>476</spage><epage>489</epage><pages>476-489</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Signal transducer and activator of transcription (STAT) proteins are a group of transcription factors that transmit signals from the extracellular milieu of cells to the nucleus. They are crucial for the signaling of many cytokines that are mediators of allergic inflammation. Considerable information is known about the activation of STATs and their role in gene transcription; comparably much less is known about how STAT signaling is regulated. Because STATs are critical for the induction of many genes crucial for the allergic cascade and immune host defense, understanding the regulation of these molecules will provide novel insights into allergic and immunodeficiency disorders and will likely identify new targets for therapeutic interventions. This review will summarize the current understanding of the regulation of STAT signaling, emphasizing recent observations.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>15356544</pmid><doi>10.1016/j.jaci.2004.06.042</doi><tpages>14</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Biological and medical sciences Cytokine Cytokines DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation Genes Humans Hypersensitivity - immunology Hypersensitivity - physiopathology Immune system Immunologic Deficiency Syndromes - immunology Immunologic Deficiency Syndromes - physiopathology Immunopathology Jak-STAT Kinases Medical sciences methylation Mice Mice, SCID Mutation phosphatase protein inhibitor of activated STAT Protein-Tyrosine Kinases - metabolism review Signal Transduction STAT suppressor of cytokine signaling Trans-Activators - metabolism |
| title | Turning off signal transducer and activator of transcription (STAT): The negative regulation of STAT signaling |
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