AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey

Graphic A series of 11-oxa prostaglandin analogs was evaluated for FP receptor binding and activation. Several compounds having aryloxy-terminated lower chains were found to be potent agonists. Topical ocular dosing of AL- 12182, the isopropyl ester prodrug of the potent agonist 13, lowered intraocu...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-09, Vol.14 (17), p.4525-4528
Hauptverfasser:	Selliah, Robert D, Hellberg, Mark R, Sharif, Najam A, McLaughlin, Marsha A, Williams, Gary W, Scott, Daniel A, Earnest, David, Haggard, Karen S, Dennis Dean, W, Delgado, Pete, Gaines, Michael S, Conrow, Raymond E, Klimko, Peter G
Format:	Artikel
Sprache:	eng
Schlagworte:	11-Oxa prostaglandin Administration, Topical Animals Biological and medical sciences Cats Eye Glaucoma Haplorhini Medical sciences Miscellaneous Ocular Hypotension - drug therapy Pharmacology. Drug treatments Prostaglandins - administration & dosage Prostaglandins - chemistry Rabbits
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