Steroid Sulfatase and Estrogen Sulfotransferase in Human Endometrial Carcinoma

Purpose: Intratumoral metabolism and synthesis of estrogens are considered to play important roles in the pathogenesis and/or development of human endometrial carcinoma. Steroid sulfatase hydrolyzes biologically inactive estrogen sulfates to active estrogens, whereas estrogen sulfotransferase sulfon...

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Veröffentlicht in:	Clinical cancer research 2004-09, Vol.10 (17), p.5850-5856
Hauptverfasser:	UTSUNOMIYA, Hiroki, ITO, Kiyoshi, SUZUKI, Takashi, KITAMURA, Takako, KANEKO, Chika, NAKATA, Taisuke, NIIKURA, Hitoshi, OKAMURA, Kunihiro, YAEGASHI, Nobuo, SASANO, Hironobu
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases - genetics 17-Hydroxysteroid Dehydrogenases - metabolism Adenocarcinoma - enzymology Adenocarcinoma - genetics Adenocarcinoma - pathology Antineoplastic agents Aromatase - genetics Aromatase - metabolism Biological and medical sciences Carcinoma, Endometrioid - enzymology Carcinoma, Endometrioid - genetics Carcinoma, Endometrioid - pathology Endometrium - enzymology Endometrium - pathology Estrogens - metabolism Estrogens - pharmacology Female Humans Immunoenzyme Techniques Medical sciences Middle Aged Neoplasm Staging Neoplasms, Hormone-Dependent - enzymology Neoplasms, Hormone-Dependent - genetics Neoplasms, Hormone-Dependent - pathology Pharmacology. Drug treatments Prognosis Receptors, Estrogen - metabolism Reverse Transcriptase Polymerase Chain Reaction Risk Factors RNA, Messenger - genetics Steryl-Sulfatase - genetics Steryl-Sulfatase - metabolism Sulfotransferases - genetics Sulfotransferases - metabolism Tumors
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