Unmasking the Osteoinductive Effects of a G‐Protein‐Coupled Receptor (GPCR) Kinase (GRK) Inhibitor by Treatment With PTH(1–34)

The effects of GPCR systems in bone are regulated by a family of enzymes termed GRKs. We found that (1) GRK inhibition in osteoblasts has age‐dependent effects on bone mass, and (2) the anabolic actions of GRK inhibition are revealed by treatment with PTH(1–34). Introduction: The effects of G‐protei...

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Veröffentlicht in:	Journal of bone and mineral research 2004-10, Vol.19 (10), p.1661-1670
Hauptverfasser:	Wang, Liming, Quarles, L Darryl, Spurney, Robert F
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Amino Acids - urine Animals beta-Adrenergic Receptor Kinases Biological and medical sciences Biomarkers - urine Bone and Bones - metabolism Bone Density - drug effects Carrier Proteins - genetics Carrier Proteins - metabolism Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Cyclic AMP-Dependent Protein Kinases - physiology Fundamental and applied biological sciences. Psychology Glycoproteins - genetics Glycoproteins - metabolism Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Transgenic osteoblast Osteoblasts - metabolism osteoclast Osteoclasts - drug effects Osteoprotegerin parathyroid hormone Parathyroid Hormone - pharmacology parathyroid hormone/parathyroid‐related peptide Peptide Fragments - pharmacology RANK Ligand receptor Receptor Activator of Nuclear Factor-kappa B Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Parathyroid Hormone - metabolism Receptors, Tumor Necrosis Factor RNA, Messenger - metabolism Skeleton and joints Vertebrates: osteoarticular system, musculoskeletal system
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