Dexamethasone Blocks Hypoxia-induced Endothelial Dysfunction in Organ-cultured Pulmonary Arteries

We assessed the effects of dexamethasone (DEX) on hypoxia-induced dysfunction of the pulmonary endothelium using organ-cultured rabbit intrapulmonary arteries; 3-microM DEX inhibited the 7-day hypoxia (5% oxygen)-induced impairments of endothelial-dependent relaxation, cGMP accumulation, and increas...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2004-09, Vol.170 (6), p.647-655
Hauptverfasser:	Murata, Takahisa, Hori, Masatoshi, Sakamoto, Kenichi, Karaki, Hideaki, Ozaki, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antibodies Atrophy Biological and medical sciences Cells, Cultured Dexamethasone - pharmacology Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Glucocorticoids - pharmacology Hypoxia Hypoxia - complications Intensive care medicine Kinases Ligands Male Medical sciences Nitric oxide Nitric Oxide Synthase - biosynthesis Phosphorylation Protein expression Proteins Pulmonary arteries Pulmonary Artery - drug effects Pulmonary Artery - pathology Pulmonary hypertension Rabbits Smooth muscle Vascular Diseases - drug therapy Vascular Diseases - etiology Vascular Diseases - physiopathology Veins & arteries
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