Possible Roles of Runx1 and Sox9 in Incipient Intramembranous Ossification
We evaluated the detailed expression patterns of Runx1 and Sox9 in various types of bone formation, and determined whether Runx1 expression was affected by Runx2 deficiency and Runx2 expression by Runx1 deficiency. Our results indicate that both Runx1 and Sox9 are intensely expressed in the future o...
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creator | Yamashiro, Takashi Wang, Xiu‐Ping Li, Zhe Oya, Shinji Åberg, Thomas Fukunaga, Tomohiro Kamioka, Hiroshi Speck, Nancy A Takano‐Yamamoto, Teruko Thesleff, Irma |
description | We evaluated the detailed expression patterns of Runx1 and Sox9 in various types of bone formation, and determined whether Runx1 expression was affected by Runx2 deficiency and Runx2 expression by Runx1 deficiency. Our results indicate that both Runx1 and Sox9 are intensely expressed in the future osteogenic cell compartment and in cartilage. The pattern of Runx1 and Sox9 expression suggests that both genes could potentially be involved in incipient intramembranous bone formation during craniofacial development.
Introduction: Runx1, a gene essential for hematopoiesis, contains RUNX binding sites in its promoter region, suggesting possible cross‐regulation with Runx2 and potential regulatory roles in bone development. On the other hand, Sox9 is essential for chondrogenesis, and haploinsufficiency of Sox9 leads to premature ossification of the skeletal system. In this study, we studied the possible roles of Runx1 and Sox9 in bone development.
Materials and Methods: Runx1, Runx2/Osf2, and Sox9 expression was evaluated by in situ hybridization in the growing craniofacial bones of embryonic day (E)12–16 mice and in the endochondral bone‐forming regions of embryonic and postnatal long bones. In addition, we evaluated Runx2/Osf2 expression in the growing face of Runx1 knockout mice at E12.5 and Runx1 expression in Runx2 knockout mice at E14.5.
Results: Runx1 and Sox9 were expressed in cartilage, and the regions of expression expanded to the neighboring Runx2‐expressing osteogenic regions. Expression of both Runx1 and Sox9 was markedly downregulated on ossification. Runx1 and Sox9 expression was absent in the regions of endochondral bone formation and in actively modeling or remodeling bone tissues in the long bones as well as in ossified craniofacial bones. Runx2 expression was not affected by gene disruption of Runx1, whereas the expression domains of Runx1 were extended in Runx2−/− mice compared with wildtype mice.
Conclusions: Runx1 and Sox9 are specifically expressed in the osteogenic cell compartments in the craniofacial bones and the bone collar of long bones, and this expression is downregulated on terminal differentiation of osteoblasts. Our results suggest that Runx1 may play a role in incipient intramembranous bone formation. |
doi_str_mv | 10.1359/JBMR.040801 |
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Introduction: Runx1, a gene essential for hematopoiesis, contains RUNX binding sites in its promoter region, suggesting possible cross‐regulation with Runx2 and potential regulatory roles in bone development. On the other hand, Sox9 is essential for chondrogenesis, and haploinsufficiency of Sox9 leads to premature ossification of the skeletal system. In this study, we studied the possible roles of Runx1 and Sox9 in bone development.
Materials and Methods: Runx1, Runx2/Osf2, and Sox9 expression was evaluated by in situ hybridization in the growing craniofacial bones of embryonic day (E)12–16 mice and in the endochondral bone‐forming regions of embryonic and postnatal long bones. In addition, we evaluated Runx2/Osf2 expression in the growing face of Runx1 knockout mice at E12.5 and Runx1 expression in Runx2 knockout mice at E14.5.
Results: Runx1 and Sox9 were expressed in cartilage, and the regions of expression expanded to the neighboring Runx2‐expressing osteogenic regions. Expression of both Runx1 and Sox9 was markedly downregulated on ossification. Runx1 and Sox9 expression was absent in the regions of endochondral bone formation and in actively modeling or remodeling bone tissues in the long bones as well as in ossified craniofacial bones. Runx2 expression was not affected by gene disruption of Runx1, whereas the expression domains of Runx1 were extended in Runx2−/− mice compared with wildtype mice.
Conclusions: Runx1 and Sox9 are specifically expressed in the osteogenic cell compartments in the craniofacial bones and the bone collar of long bones, and this expression is downregulated on terminal differentiation of osteoblasts. Our results suggest that Runx1 may play a role in incipient intramembranous bone formation.</description><identifier>ISSN: 0884-0431</identifier><identifier>EISSN: 1523-4681</identifier><identifier>DOI: 10.1359/JBMR.040801</identifier><identifier>PMID: 15355562</identifier><identifier>CODEN: JBMREJ</identifier><language>eng</language><publisher>Washington, DC: John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR)</publisher><subject>Animals ; Biological and medical sciences ; Cartilage - metabolism ; Cell Adhesion Molecules - metabolism ; Core Binding Factor Alpha 1 Subunit ; Core Binding Factor Alpha 2 Subunit ; Core Binding Factor alpha Subunits ; DNA-Binding Proteins - metabolism ; Down-Regulation ; Facial Bones - embryology ; Facial Bones - metabolism ; Fundamental and applied biological sciences. Psychology ; High Mobility Group Proteins - metabolism ; In Situ Hybridization ; knockout/in ; Mice ; Mice, Knockout ; molecular pathways ; Neoplasm Proteins - deficiency ; Osteoblasts - physiology ; Osteogenesis - physiology ; Proto-Oncogene Proteins - metabolism ; rodent ; Skeleton and joints ; SOX9 Transcription Factor ; Transcription Factors - deficiency ; Transcription Factors - metabolism ; transcriptional factors ; Ulna - embryology ; Ulna - metabolism ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Journal of bone and mineral research, 2004-10, Vol.19 (10), p.1671-1677</ispartof><rights>Copyright © 2004 ASBMR</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4990-dbfc3144958ee9dc5937d420b2e7417b98115af4dacc5f0f26ac049be709039e3</citedby><cites>FETCH-LOGICAL-c4990-dbfc3144958ee9dc5937d420b2e7417b98115af4dacc5f0f26ac049be709039e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1359%2FJBMR.040801$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1359%2FJBMR.040801$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16164558$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15355562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamashiro, Takashi</creatorcontrib><creatorcontrib>Wang, Xiu‐Ping</creatorcontrib><creatorcontrib>Li, Zhe</creatorcontrib><creatorcontrib>Oya, Shinji</creatorcontrib><creatorcontrib>Åberg, Thomas</creatorcontrib><creatorcontrib>Fukunaga, Tomohiro</creatorcontrib><creatorcontrib>Kamioka, Hiroshi</creatorcontrib><creatorcontrib>Speck, Nancy A</creatorcontrib><creatorcontrib>Takano‐Yamamoto, Teruko</creatorcontrib><creatorcontrib>Thesleff, Irma</creatorcontrib><title>Possible Roles of Runx1 and Sox9 in Incipient Intramembranous Ossification</title><title>Journal of bone and mineral research</title><addtitle>J Bone Miner Res</addtitle><description>We evaluated the detailed expression patterns of Runx1 and Sox9 in various types of bone formation, and determined whether Runx1 expression was affected by Runx2 deficiency and Runx2 expression by Runx1 deficiency. Our results indicate that both Runx1 and Sox9 are intensely expressed in the future osteogenic cell compartment and in cartilage. The pattern of Runx1 and Sox9 expression suggests that both genes could potentially be involved in incipient intramembranous bone formation during craniofacial development.
Introduction: Runx1, a gene essential for hematopoiesis, contains RUNX binding sites in its promoter region, suggesting possible cross‐regulation with Runx2 and potential regulatory roles in bone development. On the other hand, Sox9 is essential for chondrogenesis, and haploinsufficiency of Sox9 leads to premature ossification of the skeletal system. In this study, we studied the possible roles of Runx1 and Sox9 in bone development.
Materials and Methods: Runx1, Runx2/Osf2, and Sox9 expression was evaluated by in situ hybridization in the growing craniofacial bones of embryonic day (E)12–16 mice and in the endochondral bone‐forming regions of embryonic and postnatal long bones. In addition, we evaluated Runx2/Osf2 expression in the growing face of Runx1 knockout mice at E12.5 and Runx1 expression in Runx2 knockout mice at E14.5.
Results: Runx1 and Sox9 were expressed in cartilage, and the regions of expression expanded to the neighboring Runx2‐expressing osteogenic regions. Expression of both Runx1 and Sox9 was markedly downregulated on ossification. Runx1 and Sox9 expression was absent in the regions of endochondral bone formation and in actively modeling or remodeling bone tissues in the long bones as well as in ossified craniofacial bones. Runx2 expression was not affected by gene disruption of Runx1, whereas the expression domains of Runx1 were extended in Runx2−/− mice compared with wildtype mice.
Conclusions: Runx1 and Sox9 are specifically expressed in the osteogenic cell compartments in the craniofacial bones and the bone collar of long bones, and this expression is downregulated on terminal differentiation of osteoblasts. Our results suggest that Runx1 may play a role in incipient intramembranous bone formation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cartilage - metabolism</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Core Binding Factor Alpha 1 Subunit</subject><subject>Core Binding Factor Alpha 2 Subunit</subject><subject>Core Binding Factor alpha Subunits</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Down-Regulation</subject><subject>Facial Bones - embryology</subject><subject>Facial Bones - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>High Mobility Group Proteins - metabolism</subject><subject>In Situ Hybridization</subject><subject>knockout/in</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>molecular pathways</subject><subject>Neoplasm Proteins - deficiency</subject><subject>Osteoblasts - physiology</subject><subject>Osteogenesis - physiology</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>rodent</subject><subject>Skeleton and joints</subject><subject>SOX9 Transcription Factor</subject><subject>Transcription Factors - deficiency</subject><subject>Transcription Factors - metabolism</subject><subject>transcriptional factors</subject><subject>Ulna - embryology</subject><subject>Ulna - metabolism</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0884-0431</issn><issn>1523-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0LtOwzAUgGELgWgpTOwoCywo5Zz4kniEiltVVFRgjhzHloxyKXEr2rfHpZW6gRd7-Hxs_YScIwyRcnkzvnuZDYFBBnhA-sgTGjOR4SHpQ5axGBjFHjnx_hMABBfimPSQU865SPpk_Np674rKRLO2Mj5qbTRbNiuMVFNGb-1KRq6Jnhvt5s40i3BadKo2ddGppl36aBouW6fVwrXNKTmyqvLmbLcPyMfD_fvoKZ5MH59Ht5NYMykhLgurKTImeWaMLDWXNC1ZAkViUoZpITNEriwrldbcgk2E0sBkYVKQQKWhA3K1nTvv2q-l8Yu8dl6bqlKNCX_Khch4ikj_hZiGRSkL8HoLdRdqdMbm887VqlvnCPmmcb5pnG8bB32xG7ssalPu7S5qAJc7oLxWlQ2ttPN7J1AwzrPg0q37dpVZ__Xm75kLDigREOgPDPyS1w</recordid><startdate>200410</startdate><enddate>200410</enddate><creator>Yamashiro, Takashi</creator><creator>Wang, Xiu‐Ping</creator><creator>Li, Zhe</creator><creator>Oya, Shinji</creator><creator>Åberg, Thomas</creator><creator>Fukunaga, Tomohiro</creator><creator>Kamioka, Hiroshi</creator><creator>Speck, Nancy A</creator><creator>Takano‐Yamamoto, Teruko</creator><creator>Thesleff, Irma</creator><general>John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR)</general><general>American Society for Bone and Mineral Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>200410</creationdate><title>Possible Roles of Runx1 and Sox9 in Incipient Intramembranous Ossification</title><author>Yamashiro, Takashi ; Wang, Xiu‐Ping ; Li, Zhe ; Oya, Shinji ; Åberg, Thomas ; Fukunaga, Tomohiro ; Kamioka, Hiroshi ; Speck, Nancy A ; Takano‐Yamamoto, Teruko ; Thesleff, Irma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4990-dbfc3144958ee9dc5937d420b2e7417b98115af4dacc5f0f26ac049be709039e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cartilage - metabolism</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Core Binding Factor Alpha 1 Subunit</topic><topic>Core Binding Factor Alpha 2 Subunit</topic><topic>Core Binding Factor alpha Subunits</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Down-Regulation</topic><topic>Facial Bones - embryology</topic><topic>Facial Bones - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>High Mobility Group Proteins - metabolism</topic><topic>In Situ Hybridization</topic><topic>knockout/in</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>molecular pathways</topic><topic>Neoplasm Proteins - deficiency</topic><topic>Osteoblasts - physiology</topic><topic>Osteogenesis - physiology</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>rodent</topic><topic>Skeleton and joints</topic><topic>SOX9 Transcription Factor</topic><topic>Transcription Factors - deficiency</topic><topic>Transcription Factors - metabolism</topic><topic>transcriptional factors</topic><topic>Ulna - embryology</topic><topic>Ulna - metabolism</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamashiro, Takashi</creatorcontrib><creatorcontrib>Wang, Xiu‐Ping</creatorcontrib><creatorcontrib>Li, Zhe</creatorcontrib><creatorcontrib>Oya, Shinji</creatorcontrib><creatorcontrib>Åberg, Thomas</creatorcontrib><creatorcontrib>Fukunaga, Tomohiro</creatorcontrib><creatorcontrib>Kamioka, Hiroshi</creatorcontrib><creatorcontrib>Speck, Nancy A</creatorcontrib><creatorcontrib>Takano‐Yamamoto, Teruko</creatorcontrib><creatorcontrib>Thesleff, Irma</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and mineral research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamashiro, Takashi</au><au>Wang, Xiu‐Ping</au><au>Li, Zhe</au><au>Oya, Shinji</au><au>Åberg, Thomas</au><au>Fukunaga, Tomohiro</au><au>Kamioka, Hiroshi</au><au>Speck, Nancy A</au><au>Takano‐Yamamoto, Teruko</au><au>Thesleff, Irma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible Roles of Runx1 and Sox9 in Incipient Intramembranous Ossification</atitle><jtitle>Journal of bone and mineral research</jtitle><addtitle>J Bone Miner Res</addtitle><date>2004-10</date><risdate>2004</risdate><volume>19</volume><issue>10</issue><spage>1671</spage><epage>1677</epage><pages>1671-1677</pages><issn>0884-0431</issn><eissn>1523-4681</eissn><coden>JBMREJ</coden><abstract>We evaluated the detailed expression patterns of Runx1 and Sox9 in various types of bone formation, and determined whether Runx1 expression was affected by Runx2 deficiency and Runx2 expression by Runx1 deficiency. Our results indicate that both Runx1 and Sox9 are intensely expressed in the future osteogenic cell compartment and in cartilage. The pattern of Runx1 and Sox9 expression suggests that both genes could potentially be involved in incipient intramembranous bone formation during craniofacial development.
Introduction: Runx1, a gene essential for hematopoiesis, contains RUNX binding sites in its promoter region, suggesting possible cross‐regulation with Runx2 and potential regulatory roles in bone development. On the other hand, Sox9 is essential for chondrogenesis, and haploinsufficiency of Sox9 leads to premature ossification of the skeletal system. In this study, we studied the possible roles of Runx1 and Sox9 in bone development.
Materials and Methods: Runx1, Runx2/Osf2, and Sox9 expression was evaluated by in situ hybridization in the growing craniofacial bones of embryonic day (E)12–16 mice and in the endochondral bone‐forming regions of embryonic and postnatal long bones. In addition, we evaluated Runx2/Osf2 expression in the growing face of Runx1 knockout mice at E12.5 and Runx1 expression in Runx2 knockout mice at E14.5.
Results: Runx1 and Sox9 were expressed in cartilage, and the regions of expression expanded to the neighboring Runx2‐expressing osteogenic regions. Expression of both Runx1 and Sox9 was markedly downregulated on ossification. Runx1 and Sox9 expression was absent in the regions of endochondral bone formation and in actively modeling or remodeling bone tissues in the long bones as well as in ossified craniofacial bones. Runx2 expression was not affected by gene disruption of Runx1, whereas the expression domains of Runx1 were extended in Runx2−/− mice compared with wildtype mice.
Conclusions: Runx1 and Sox9 are specifically expressed in the osteogenic cell compartments in the craniofacial bones and the bone collar of long bones, and this expression is downregulated on terminal differentiation of osteoblasts. Our results suggest that Runx1 may play a role in incipient intramembranous bone formation.</abstract><cop>Washington, DC</cop><pub>John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR)</pub><pmid>15355562</pmid><doi>10.1359/JBMR.040801</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Biological and medical sciences Cartilage - metabolism Cell Adhesion Molecules - metabolism Core Binding Factor Alpha 1 Subunit Core Binding Factor Alpha 2 Subunit Core Binding Factor alpha Subunits DNA-Binding Proteins - metabolism Down-Regulation Facial Bones - embryology Facial Bones - metabolism Fundamental and applied biological sciences. Psychology High Mobility Group Proteins - metabolism In Situ Hybridization knockout/in Mice Mice, Knockout molecular pathways Neoplasm Proteins - deficiency Osteoblasts - physiology Osteogenesis - physiology Proto-Oncogene Proteins - metabolism rodent Skeleton and joints SOX9 Transcription Factor Transcription Factors - deficiency Transcription Factors - metabolism transcriptional factors Ulna - embryology Ulna - metabolism Vertebrates: osteoarticular system, musculoskeletal system |
title | Possible Roles of Runx1 and Sox9 in Incipient Intramembranous Ossification |
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