A possible role for nitric oxide in osteoclastogenesis associated with cholesteatoma

This study was designed to investigate the potential role of nitric oxide in cholesteatoma-induced bone resorption, in vitro and in vivo. Cholesteatoma is a disease of inflammatory bone resorption in the middle ear leading to hearing loss and vestibular dysfunction. Inappropriate activation of osteo...

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Veröffentlicht in:	Otology & neurotology 2004-09, Vol.25 (5), p.661-668
Hauptverfasser:	Jung, Jae Y, Pashia, Mary E, Nishimoto, Sheri Y, Faddis, Brian T, Chole, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Resorption - enzymology Bone Resorption - etiology Bone Resorption - physiopathology Cells, Cultured Cholesteatoma - complications Cholesteatoma - pathology Cholesteatoma - physiopathology Cytokines - pharmacology Disease Models, Animal Enzyme Induction Enzyme Inhibitors - pharmacology Gene Expression Regulation, Enzymologic Guanidines - pharmacology Male Mice Mice, Inbred C57BL Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Osteoclasts - cytology Osteoclasts - physiology Random Allocation Tumor Necrosis Factor-alpha
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