Effects of Treatment with Anti-immunoglobulin E Antibody Omalizumab on Airway Inflammation in Allergic Asthma

IgE plays an important role in allergic asthma. We hypothesized that reducing IgE in the airway mucosa would reduce airway inflammation. Forty-five patients with mild to moderate persistent asthma with sputum eosinophilia of 2% or more were treated with humanized monoclonal antibody against IgE (oma...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2004-09, Vol.170 (6), p.583-593
Hauptverfasser:	Djukanovic, Ratko, Wilson, Susan J, Kraft, Monica, Jarjour, Nizar N, Steel, Mark, Chung, K. Fan, Bao, Weibin, Fowler-Taylor, Angel, Matthews, John, Busse, William W, Holgate, Stephen T, Fahy, John V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anti-Asthmatic Agents - immunology Anti-Asthmatic Agents - therapeutic use Antibodies, Anti-Idiotypic Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Asthma - drug therapy Asthma - immunology Biological and medical sciences Bronchi - drug effects Bronchi - immunology Double-Blind Method Eosinophilia - immunology Female Humans Immunoglobulin E - immunology Inflammation - immunology Intensive care medicine Male Medical sciences Middle Aged Omalizumab Respiratory Mucosa - drug effects Respiratory Mucosa - immunology Sputum - immunology Treatment Outcome
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