Short-term iontophoretic and post-iontophoretic transport of model penetrants across excised human epidermis

The effect of short-term current application (0.4 mA for 10 min) on the epidermal transport of two model penetrants (butyl paraben, BP; caffeine, CF) of differing lipohilicity was investigated and compared to that produced by employing an established method of skin penetration enhancement (delipidis...

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Veröffentlicht in:	International journal of pharmaceutics 2009-02, Vol.367 (1), p.162-168
Hauptverfasser:	Akomeah, Franklin K., Martin, Gary P., Brown, Marc B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Caffeine Caffeine - administration & dosage Caffeine - pharmacokinetics Chromatography, High Pressure Liquid Electrochemistry Electrodes Electroperturbation Epidermis - metabolism Epidermis - ultrastructure Humans In Vitro Techniques Iontophoresis Microscopy, Electron, Scanning Models, Biological Paraben Parabens - administration & dosage Parabens - pharmacokinetics Skin Absorption Skin permeability Solvents - chemistry Surface Properties Time Factors Topical delivery
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