A Chemical Genomic Approach Identifies Matrix Metalloproteinases as Playing an Essential and Specific Role in Xenopus Melanophore Migration

To dissect the function of matrix metalloproteinases (MMPs) involved in cellular migration in vivo, we undertook both a forward chemical genomic screen and a functional approach to discover modulators of melanophore (pigment cell) migration in Xenopus laevis. We identified the 8-quinolinol derivativ...

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Veröffentlicht in:	Chemistry & biology 2009-01, Vol.16 (1), p.93-104
Hauptverfasser:	Tomlinson, Matthew L., Guan, Pingping, Morris, Richard J., Fidock, Mark D., Rejzek, Martin, Garcia-Morales, Carla, Field, Robert A., Wheeler, Grant N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - chemistry Aniline Compounds - pharmacology Animals Cell Movement - genetics CELLBIO CHEMBIO DEVIO Embryo, Nonmammalian - enzymology Embryonic Development Humans Hydroxyquinolines - chemistry Hydroxyquinolines - pharmacology Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase Inhibitors Matrix Metalloproteinases - metabolism Melanophores - enzymology Melanophores - metabolism Skin Pigmentation Structure-Activity Relationship Xenopus laevis Xenopus laevis - embryology Xenopus laevis - metabolism
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