Pathobiology of triple reassortant H3N2 influenza viruses in breeder turkeys and its potential implication for vaccine studies in turkeys
Abstract Triple reassortant (TR) H3N2 influenza viruses have been isolated from turkeys in the United States since 2003. These TR H3N2 virus infections have been associated with drastic declines in egg production in breeder turkeys although co-infection with multiple agents could have been responsib...
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| Veröffentlicht in: | Vaccine 2009-02, Vol.27 (6), p.819-824 |
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| creator | Pillai, S.P.S Pantin-Jackwood, M Jadhao, S.J Suarez, D.L Wang, L Yassine, H.M Saif, Y.M Lee, C.-W |
| description | Abstract Triple reassortant (TR) H3N2 influenza viruses have been isolated from turkeys in the United States since 2003. These TR H3N2 virus infections have been associated with drastic declines in egg production in breeder turkeys although co-infection with multiple agents could have been responsible for exacerbating the clinical signs. In this study, we experimentally confirmed that TR H3N2 influenza virus alone can cause drastic reduction/complete cessation of egg production and pathology of the reproductive tract in 26-week-old breeder turkeys. We confirmed high levels of virus replication and abundant distribution of avian specific α2,3 sialic acid-galactose receptors in the oviduct of these turkeys. Although 2–6-week-old turkeys are routinely used for pathogenicity and vaccine protection studies, the low levels of viral shedding and asymptomatic infections in this age group often pose difficulty in interpretation of results. Our study shows that breeder turkeys should be used to assess the potential pathogenicity of TR H3N2 viruses and the viral titers and pathology of the oviduct as well as egg production data can be good measures of protection following in vivo challenge in vaccine efficacy studies. |
| doi_str_mv | 10.1016/j.vaccine.2008.11.076 |
| format | Article |
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These TR H3N2 virus infections have been associated with drastic declines in egg production in breeder turkeys although co-infection with multiple agents could have been responsible for exacerbating the clinical signs. In this study, we experimentally confirmed that TR H3N2 influenza virus alone can cause drastic reduction/complete cessation of egg production and pathology of the reproductive tract in 26-week-old breeder turkeys. We confirmed high levels of virus replication and abundant distribution of avian specific α2,3 sialic acid-galactose receptors in the oviduct of these turkeys. Although 2–6-week-old turkeys are routinely used for pathogenicity and vaccine protection studies, the low levels of viral shedding and asymptomatic infections in this age group often pose difficulty in interpretation of results. Our study shows that breeder turkeys should be used to assess the potential pathogenicity of TR H3N2 viruses and the viral titers and pathology of the oviduct as well as egg production data can be good measures of protection following in vivo challenge in vaccine efficacy studies.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2008.11.076</identifier><identifier>PMID: 19071183</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Allergy and Immunology ; Animals ; Applied microbiology ; Biological and medical sciences ; Birds ; Breeder turkeys ; Egg production ; Female ; Fundamental and applied biological sciences. Psychology ; Genitalia, Female - chemistry ; Genitalia, Female - pathology ; Genitalia, Female - virology ; H3N2 ; Hogs ; Immunization ; Infections ; Influenza ; Influenza A Virus, H3N2 Subtype - immunology ; Influenza A Virus, H3N2 Subtype - pathogenicity ; Influenza in Birds - immunology ; Influenza in Birds - pathology ; Influenza in Birds - virology ; Influenza Vaccines - immunology ; Mammals ; Medical research ; Microbiology ; Pathogens ; Pathology ; Reassortant Viruses - immunology ; Reassortant Viruses - pathogenicity ; Receptors, Virus - analysis ; Studies ; Triple reassortants ; Turkeys ; United States ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Viral infections ; Viruses ; Wildfowl</subject><ispartof>Vaccine, 2009-02, Vol.27 (6), p.819-824</ispartof><rights>Elsevier Ltd</rights><rights>2008 Elsevier Ltd</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Elsevier Limited Feb 5, 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-6f51e0a95bf47b7a2b2192c810460980fa0e68e7d3a614780ad4f63e62a398033</citedby><cites>FETCH-LOGICAL-c476t-6f51e0a95bf47b7a2b2192c810460980fa0e68e7d3a614780ad4f63e62a398033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X08015910$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21234881$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19071183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pillai, S.P.S</creatorcontrib><creatorcontrib>Pantin-Jackwood, M</creatorcontrib><creatorcontrib>Jadhao, S.J</creatorcontrib><creatorcontrib>Suarez, D.L</creatorcontrib><creatorcontrib>Wang, L</creatorcontrib><creatorcontrib>Yassine, H.M</creatorcontrib><creatorcontrib>Saif, Y.M</creatorcontrib><creatorcontrib>Lee, C.-W</creatorcontrib><title>Pathobiology of triple reassortant H3N2 influenza viruses in breeder turkeys and its potential implication for vaccine studies in turkeys</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract Triple reassortant (TR) H3N2 influenza viruses have been isolated from turkeys in the United States since 2003. These TR H3N2 virus infections have been associated with drastic declines in egg production in breeder turkeys although co-infection with multiple agents could have been responsible for exacerbating the clinical signs. In this study, we experimentally confirmed that TR H3N2 influenza virus alone can cause drastic reduction/complete cessation of egg production and pathology of the reproductive tract in 26-week-old breeder turkeys. We confirmed high levels of virus replication and abundant distribution of avian specific α2,3 sialic acid-galactose receptors in the oviduct of these turkeys. Although 2–6-week-old turkeys are routinely used for pathogenicity and vaccine protection studies, the low levels of viral shedding and asymptomatic infections in this age group often pose difficulty in interpretation of results. Our study shows that breeder turkeys should be used to assess the potential pathogenicity of TR H3N2 viruses and the viral titers and pathology of the oviduct as well as egg production data can be good measures of protection following in vivo challenge in vaccine efficacy studies.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Birds</subject><subject>Breeder turkeys</subject><subject>Egg production</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genitalia, Female - chemistry</subject><subject>Genitalia, Female - pathology</subject><subject>Genitalia, Female - virology</subject><subject>H3N2</subject><subject>Hogs</subject><subject>Immunization</subject><subject>Infections</subject><subject>Influenza</subject><subject>Influenza A Virus, H3N2 Subtype - immunology</subject><subject>Influenza A Virus, H3N2 Subtype - pathogenicity</subject><subject>Influenza in Birds - immunology</subject><subject>Influenza in Birds - pathology</subject><subject>Influenza in Birds - virology</subject><subject>Influenza Vaccines - immunology</subject><subject>Mammals</subject><subject>Medical research</subject><subject>Microbiology</subject><subject>Pathogens</subject><subject>Pathology</subject><subject>Reassortant Viruses - immunology</subject><subject>Reassortant Viruses - pathogenicity</subject><subject>Receptors, Virus - analysis</subject><subject>Studies</subject><subject>Triple reassortants</subject><subject>Turkeys</subject><subject>United States</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Viral infections</subject><subject>Viruses</subject><subject>Wildfowl</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFklGL1DAUhYso7rr6E5SA6NuM96Ztmr4osqgrLCqo4FtI01vNmEnGJB0Y_4H_2gxTXNgXnwLJdw7n5tyqeoywRkDxYrPea2OspzUHkGvENXTiTnWOsqtXvEV5tzoHLppVg_DtrHqQ0gYA2hr7-9UZ9tAhyvq8-vNJ5x9hsMGF7wcWJpaj3TlikXRKIWbtM7uqP3Bm_eRm8r8129s4J0rlhg2RaKTI8hx_0iEx7Udmc2K7kMlnqx2z252zRmcbPJtCZEtolvI82pPJIn5Y3Zu0S_RoOS-qr2_ffLm8Wl1_fPf-8vX1yjSdyCsxtUig-3aYmm7oNB849txIhEZAL2HSQEJSN9ZaYNNJ0GMziZoE13V5ruuL6vnJdxfDr5lSVlubDDmnPYU5KSFk2yI_gk9vgZswR1-yKRQoJW9bzgvVnigTQ0qRJrWLdqvjQSGoY1Nqo5ah1bEphahKU0X3ZHGfhy2NN6qlmgI8WwCdjHZT1N7Y9I_jJWIjJRbu1Ymj8ml7S1ElY8kbGm0kk9UY7H-jvLzlYJz1pTVXeqF0M7VKXIH6fFyr41aBBGx7hPov0xfKjQ</recordid><startdate>20090205</startdate><enddate>20090205</enddate><creator>Pillai, S.P.S</creator><creator>Pantin-Jackwood, M</creator><creator>Jadhao, S.J</creator><creator>Suarez, D.L</creator><creator>Wang, L</creator><creator>Yassine, H.M</creator><creator>Saif, Y.M</creator><creator>Lee, C.-W</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20090205</creationdate><title>Pathobiology of triple reassortant H3N2 influenza viruses in breeder turkeys and its potential implication for vaccine studies in turkeys</title><author>Pillai, S.P.S ; Pantin-Jackwood, M ; Jadhao, S.J ; Suarez, D.L ; Wang, L ; Yassine, H.M ; Saif, Y.M ; Lee, C.-W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-6f51e0a95bf47b7a2b2192c810460980fa0e68e7d3a614780ad4f63e62a398033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Birds</topic><topic>Breeder turkeys</topic><topic>Egg production</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genitalia, Female - chemistry</topic><topic>Genitalia, Female - pathology</topic><topic>Genitalia, Female - virology</topic><topic>H3N2</topic><topic>Hogs</topic><topic>Immunization</topic><topic>Infections</topic><topic>Influenza</topic><topic>Influenza A Virus, H3N2 Subtype - immunology</topic><topic>Influenza A Virus, H3N2 Subtype - pathogenicity</topic><topic>Influenza in Birds - immunology</topic><topic>Influenza in Birds - pathology</topic><topic>Influenza in Birds - virology</topic><topic>Influenza Vaccines - immunology</topic><topic>Mammals</topic><topic>Medical research</topic><topic>Microbiology</topic><topic>Pathogens</topic><topic>Pathology</topic><topic>Reassortant Viruses - immunology</topic><topic>Reassortant Viruses - pathogenicity</topic><topic>Receptors, Virus - analysis</topic><topic>Studies</topic><topic>Triple reassortants</topic><topic>Turkeys</topic><topic>United States</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Viral infections</topic><topic>Viruses</topic><topic>Wildfowl</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pillai, S.P.S</creatorcontrib><creatorcontrib>Pantin-Jackwood, M</creatorcontrib><creatorcontrib>Jadhao, S.J</creatorcontrib><creatorcontrib>Suarez, D.L</creatorcontrib><creatorcontrib>Wang, L</creatorcontrib><creatorcontrib>Yassine, H.M</creatorcontrib><creatorcontrib>Saif, Y.M</creatorcontrib><creatorcontrib>Lee, C.-W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pillai, S.P.S</au><au>Pantin-Jackwood, M</au><au>Jadhao, S.J</au><au>Suarez, D.L</au><au>Wang, L</au><au>Yassine, H.M</au><au>Saif, Y.M</au><au>Lee, C.-W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathobiology of triple reassortant H3N2 influenza viruses in breeder turkeys and its potential implication for vaccine studies in turkeys</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2009-02-05</date><risdate>2009</risdate><volume>27</volume><issue>6</issue><spage>819</spage><epage>824</epage><pages>819-824</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Abstract Triple reassortant (TR) H3N2 influenza viruses have been isolated from turkeys in the United States since 2003. These TR H3N2 virus infections have been associated with drastic declines in egg production in breeder turkeys although co-infection with multiple agents could have been responsible for exacerbating the clinical signs. In this study, we experimentally confirmed that TR H3N2 influenza virus alone can cause drastic reduction/complete cessation of egg production and pathology of the reproductive tract in 26-week-old breeder turkeys. We confirmed high levels of virus replication and abundant distribution of avian specific α2,3 sialic acid-galactose receptors in the oviduct of these turkeys. Although 2–6-week-old turkeys are routinely used for pathogenicity and vaccine protection studies, the low levels of viral shedding and asymptomatic infections in this age group often pose difficulty in interpretation of results. Our study shows that breeder turkeys should be used to assess the potential pathogenicity of TR H3N2 viruses and the viral titers and pathology of the oviduct as well as egg production data can be good measures of protection following in vivo challenge in vaccine efficacy studies.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>19071183</pmid><doi>10.1016/j.vaccine.2008.11.076</doi><tpages>6</tpages></addata></record> |
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| subjects | Allergy and Immunology Animals Applied microbiology Biological and medical sciences Birds Breeder turkeys Egg production Female Fundamental and applied biological sciences. Psychology Genitalia, Female - chemistry Genitalia, Female - pathology Genitalia, Female - virology H3N2 Hogs Immunization Infections Influenza Influenza A Virus, H3N2 Subtype - immunology Influenza A Virus, H3N2 Subtype - pathogenicity Influenza in Birds - immunology Influenza in Birds - pathology Influenza in Birds - virology Influenza Vaccines - immunology Mammals Medical research Microbiology Pathogens Pathology Reassortant Viruses - immunology Reassortant Viruses - pathogenicity Receptors, Virus - analysis Studies Triple reassortants Turkeys United States Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral infections Viruses Wildfowl |
| title | Pathobiology of triple reassortant H3N2 influenza viruses in breeder turkeys and its potential implication for vaccine studies in turkeys |
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