Effect of 5-HT1A gene polymorphisms on antidepressant response in major depressive disorder

Variability in antidepressant response is due to genetic and environmental factors. Among genetic factors, the ones controlling for availability of the drug at the target site are interesting candidates. Rs6295C/G SNP in the 5‐HT1A gene (HTR1A) has been found to affect the expression and function of...

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Veröffentlicht in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2009-01, Vol.150B (1), p.115-123
Hauptverfasser: Kato, Masaki, Fukuda, Tsuyoshi, Wakeno, Masataka, Okugawa, Gaku, Takekita, Yoshiteru, Watanabe, Syunsuke, Yamashita, Megumi, Hosoi, Yuka, Azuma, Junichi, Kinoshita, Toshihiko, Serretti, Alessandro
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Sprache:eng
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Zusammenfassung:Variability in antidepressant response is due to genetic and environmental factors. Among genetic factors, the ones controlling for availability of the drug at the target site are interesting candidates. Rs6295C/G SNP in the 5‐HT1A gene (HTR1A) has been found to affect the expression and function of HTR1A. In fact rs6295C/G is in strong linkage disequilibrium with other polymorphisms of HTR1A suggesting that those functional effects could be associated with polymorphisms other than or together with the synonymous rs6295C/G. In the present study we examined the possible association of a panel of markers in strong linkage disequilibrium of the HTR1A with SSRI/SNRI response in 137 Japanese major depression subjects followed for 6 weeks. We observed a significant association of better response to antidepressant in rs10042486C/C (P 
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.30783