Marked inhibition of retinal neovascularization in rats following soluble-flt-1 gene transfer

Background In mouse models of retinopathy of prematurity (ROP) inhibitors of vascular endothelial growth factor (VEGF) functions administered systemically completely block retinal neovascularization. In contrast, selective ocular VEGF depletion has achieved an approx. 50% inhibition of retinal neova...

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Veröffentlicht in:	The journal of gene medicine 2004-09, Vol.6 (9), p.992-1002
Hauptverfasser:	Rota, Rossella, Riccioni, Teresa, Zaccarini, Marco, Lamartina, Stefania, Gallo, Anna Del, Fusco, Angelo, Kovesdi, Imre, Balestrazzi, Emilio, Abeni, Damiano C., Ali, Robin R., Capogrossi, Maurizio C.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenoviral vector Adenoviridae - genetics Animals Disease Models, Animal Gene therapy Genetic Therapy - methods Genetic Vectors - therapeutic use Humans Infant, Newborn Rats Retina - pathology retinal neovascularization Retinal Neovascularization - prevention & control Retinopathy of Prematurity - therapy vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-1 - biosynthesis Vascular Endothelial Growth Factor Receptor-1 - genetics Vascular Endothelial Growth Factor Receptor-1 - therapeutic use Vitreous Body - metabolism
Online-Zugang:	Volltext
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