Involvement of NAD(P)H oxidase in the enhanced expression of cell adhesion molecules in the aorta of diabetic mice

The increased levels of cell adhesion molecules (CAM) have been identified in diabetic vasculatures, but the underlying mechanisms remain unclear. To determine the relationship among vascular production of superoxide, expression of CAM and diabetes, superoxide generation and expression of intercellu...

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Veröffentlicht in:	Life sciences (1973) 2004-10, Vol.75 (20), p.2463-2472
Hauptverfasser:	Yun, Mi Ran, Kim, Jong Jae, Im, Dong Sun, Yang, Seung Don, Kim, Chi Dae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - cytology Aorta - metabolism Cell Adhesion Cell adhesion molecules Diabetes Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology E-Selectin - metabolism Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Ethidium - analogs & derivatives Ethidium - pharmacology Immunoenzyme Techniques Intercellular Adhesion Molecule-1 - metabolism Male Mice Mice, Inbred C57BL Mice, Obese NAD(P)H oxidase NADH, NADPH Oxidoreductases - metabolism NADPH Oxidases Oxygen free radicals P-Selectin - metabolism Superoxides - metabolism Vascular Cell Adhesion Molecule-1 - metabolism
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