BDNF overexpression produces a long-term increase in myelin formation in the peripheral nervous system
The neurotrophin brain‐derived neurotrophic factor (BDNF) is an endogenous regulator of the myelination process during development in the peripheral nervous system. Enhancement of myelin formation by BDNF is mediated by the neurotrophin receptor p75NTR. Although this neurotrophin is a positive modul...
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| Veröffentlicht in: | Journal of neuroscience research 2004-09, Vol.77 (5), p.662-669 |
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| container_title | Journal of neuroscience research |
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| creator | Tolwani, Ravi J. Cosgaya, José M. Varma, Sushama Jacob, Reza Kuo, Lydia E. Shooter, Eric M. |
| description | The neurotrophin brain‐derived neurotrophic factor (BDNF) is an endogenous regulator of the myelination process during development in the peripheral nervous system. Enhancement of myelin formation by BDNF is mediated by the neurotrophin receptor p75NTR. Although this neurotrophin is a positive modulator of myelination during early development, the final effects of BDNF on myelin sheaths after active myelination is completed are largely unknown. Using BDNF transgenic mice, we examined the long‐term effects of BDNF on myelination of the peripheral nervous system in vivo. Elevation of BDNF levels in the transgenic mice produced an increase in both the rate and extent of the myelination process. BDNF enhanced and accelerated myelin formation during early development and this increase in myelin content and thickness was maintained in adulthood. Besides enhanced myelination, BDNF also influenced axon caliber size but to a lesser extent. This lagging increase in axon caliber compared to myelin suggests that the axon size is not the only determinant of myelin thickness. © 2004 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jnr.20181 |
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Enhancement of myelin formation by BDNF is mediated by the neurotrophin receptor p75NTR. Although this neurotrophin is a positive modulator of myelination during early development, the final effects of BDNF on myelin sheaths after active myelination is completed are largely unknown. Using BDNF transgenic mice, we examined the long‐term effects of BDNF on myelination of the peripheral nervous system in vivo. Elevation of BDNF levels in the transgenic mice produced an increase in both the rate and extent of the myelination process. BDNF enhanced and accelerated myelin formation during early development and this increase in myelin content and thickness was maintained in adulthood. Besides enhanced myelination, BDNF also influenced axon caliber size but to a lesser extent. This lagging increase in axon caliber compared to myelin suggests that the axon size is not the only determinant of myelin thickness. © 2004 Wiley‐Liss, Inc.</description><identifier>ISSN: 0360-4012</identifier><identifier>EISSN: 1097-4547</identifier><identifier>DOI: 10.1002/jnr.20181</identifier><identifier>PMID: 15352212</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; axon caliber ; Axons - ultrastructure ; Blotting, Southern - methods ; Blotting, Western - methods ; Brain-Derived Neurotrophic Factor - genetics ; Brain-Derived Neurotrophic Factor - metabolism ; Brain-Derived Neurotrophic Factor - physiology ; Gene Expression Regulation - physiology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microscopy, Electron, Transmission - methods ; mouse ; Myelin Proteins - metabolism ; myelin sheath ; Myelin Sheath - physiology ; myelin-associated glycoprotein ; Peripheral Nervous System - physiology ; Peripheral Nervous System - ultrastructure ; protein zero ; Reverse Transcriptase Polymerase Chain Reaction - methods ; RNA, Messenger - biosynthesis ; Sciatic Nerve - metabolism ; Sciatic Nerve - ultrastructure ; Time Factors ; transgenic</subject><ispartof>Journal of neuroscience research, 2004-09, Vol.77 (5), p.662-669</ispartof><rights>Copyright © 2004 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4561-4edf8dd2c0e58f2254eeff0855dc7ae13fde8bd5a6d84cbd5dd57a3a67c6fe333</citedby><cites>FETCH-LOGICAL-c4561-4edf8dd2c0e58f2254eeff0855dc7ae13fde8bd5a6d84cbd5dd57a3a67c6fe333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjnr.20181$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjnr.20181$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15352212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tolwani, Ravi J.</creatorcontrib><creatorcontrib>Cosgaya, José M.</creatorcontrib><creatorcontrib>Varma, Sushama</creatorcontrib><creatorcontrib>Jacob, Reza</creatorcontrib><creatorcontrib>Kuo, Lydia E.</creatorcontrib><creatorcontrib>Shooter, Eric M.</creatorcontrib><title>BDNF overexpression produces a long-term increase in myelin formation in the peripheral nervous system</title><title>Journal of neuroscience research</title><addtitle>J. Neurosci. Res</addtitle><description>The neurotrophin brain‐derived neurotrophic factor (BDNF) is an endogenous regulator of the myelination process during development in the peripheral nervous system. Enhancement of myelin formation by BDNF is mediated by the neurotrophin receptor p75NTR. Although this neurotrophin is a positive modulator of myelination during early development, the final effects of BDNF on myelin sheaths after active myelination is completed are largely unknown. Using BDNF transgenic mice, we examined the long‐term effects of BDNF on myelination of the peripheral nervous system in vivo. Elevation of BDNF levels in the transgenic mice produced an increase in both the rate and extent of the myelination process. BDNF enhanced and accelerated myelin formation during early development and this increase in myelin content and thickness was maintained in adulthood. Besides enhanced myelination, BDNF also influenced axon caliber size but to a lesser extent. This lagging increase in axon caliber compared to myelin suggests that the axon size is not the only determinant of myelin thickness. © 2004 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>axon caliber</subject><subject>Axons - ultrastructure</subject><subject>Blotting, Southern - methods</subject><subject>Blotting, Western - methods</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Brain-Derived Neurotrophic Factor - physiology</subject><subject>Gene Expression Regulation - physiology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Microscopy, Electron, Transmission - methods</subject><subject>mouse</subject><subject>Myelin Proteins - metabolism</subject><subject>myelin sheath</subject><subject>Myelin Sheath - physiology</subject><subject>myelin-associated glycoprotein</subject><subject>Peripheral Nervous System - physiology</subject><subject>Peripheral Nervous System - ultrastructure</subject><subject>protein zero</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Sciatic Nerve - metabolism</subject><subject>Sciatic Nerve - ultrastructure</subject><subject>Time Factors</subject><subject>transgenic</subject><issn>0360-4012</issn><issn>1097-4547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PVDEUhhuigXFk4R8wXZmwuNDvdpY4wiiBISEqy6a0p3LhftneQebfW5xRVobVOU2e903Pg9A7Sg4pIezorkuHjFBDd9CEkpmuhBT6FZoQrkglCGV76E3Od4SQ2UzyXbRHJZeMUTZB8eOn5SnuHyDB45Ag57rv8JD6sPKQscNN3_2oRkgtrjufwGUoC27X0JQR-9S68SlRHuMt4AFSPdxCcg3uID30q4zzOo_QvkWvo2sy7G_nFH07Pfk6_1ydXy6-zI_PKy-kopWAEE0IzBOQJjImBUCMxEgZvHZAeQxgboJ0KhjhyxKC1I47pb2KwDmfog-b3nLCzxXk0bZ19tA0roPyG6uUkcxQ-iJItdSCFFtTdLABfepzThDtkOrWpbWlxD7Zt8W-_WO_sO-3paubFsIzudVdgKMN8KtuYP3_Jnu2vPpbWW0SddH4-C_h0r1Vmmtpr5cLuzDiu7qan9kL_ht9u6BA</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Tolwani, Ravi J.</creator><creator>Cosgaya, José M.</creator><creator>Varma, Sushama</creator><creator>Jacob, Reza</creator><creator>Kuo, Lydia E.</creator><creator>Shooter, Eric M.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>BDNF overexpression produces a long-term increase in myelin formation in the peripheral nervous system</title><author>Tolwani, Ravi J. ; Cosgaya, José M. ; Varma, Sushama ; Jacob, Reza ; Kuo, Lydia E. ; Shooter, Eric M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4561-4edf8dd2c0e58f2254eeff0855dc7ae13fde8bd5a6d84cbd5dd57a3a67c6fe333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>axon caliber</topic><topic>Axons - ultrastructure</topic><topic>Blotting, Southern - methods</topic><topic>Blotting, Western - methods</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Brain-Derived Neurotrophic Factor - physiology</topic><topic>Gene Expression Regulation - physiology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>Microscopy, Electron, Transmission - methods</topic><topic>mouse</topic><topic>Myelin Proteins - metabolism</topic><topic>myelin sheath</topic><topic>Myelin Sheath - physiology</topic><topic>myelin-associated glycoprotein</topic><topic>Peripheral Nervous System - physiology</topic><topic>Peripheral Nervous System - ultrastructure</topic><topic>protein zero</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Sciatic Nerve - metabolism</topic><topic>Sciatic Nerve - ultrastructure</topic><topic>Time Factors</topic><topic>transgenic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tolwani, Ravi J.</creatorcontrib><creatorcontrib>Cosgaya, José M.</creatorcontrib><creatorcontrib>Varma, Sushama</creatorcontrib><creatorcontrib>Jacob, Reza</creatorcontrib><creatorcontrib>Kuo, Lydia E.</creatorcontrib><creatorcontrib>Shooter, Eric M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tolwani, Ravi J.</au><au>Cosgaya, José M.</au><au>Varma, Sushama</au><au>Jacob, Reza</au><au>Kuo, Lydia E.</au><au>Shooter, Eric M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BDNF overexpression produces a long-term increase in myelin formation in the peripheral nervous system</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>J. Neurosci. Res</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>77</volume><issue>5</issue><spage>662</spage><epage>669</epage><pages>662-669</pages><issn>0360-4012</issn><eissn>1097-4547</eissn><abstract>The neurotrophin brain‐derived neurotrophic factor (BDNF) is an endogenous regulator of the myelination process during development in the peripheral nervous system. Enhancement of myelin formation by BDNF is mediated by the neurotrophin receptor p75NTR. Although this neurotrophin is a positive modulator of myelination during early development, the final effects of BDNF on myelin sheaths after active myelination is completed are largely unknown. Using BDNF transgenic mice, we examined the long‐term effects of BDNF on myelination of the peripheral nervous system in vivo. Elevation of BDNF levels in the transgenic mice produced an increase in both the rate and extent of the myelination process. 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| subjects | Animals axon caliber Axons - ultrastructure Blotting, Southern - methods Blotting, Western - methods Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Brain-Derived Neurotrophic Factor - physiology Gene Expression Regulation - physiology Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Electron, Transmission - methods mouse Myelin Proteins - metabolism myelin sheath Myelin Sheath - physiology myelin-associated glycoprotein Peripheral Nervous System - physiology Peripheral Nervous System - ultrastructure protein zero Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis Sciatic Nerve - metabolism Sciatic Nerve - ultrastructure Time Factors transgenic |
| title | BDNF overexpression produces a long-term increase in myelin formation in the peripheral nervous system |
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