Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-γ signal pathways
Ginsenosides, the active component of ginseng, exerts antidiabetic and anticancer effects. This study investigated the molecular basis of ginsenoside Rg3, a red ginseng rich constituent, focusing on its ability to inhibit adipocyte differentiation in 3T3-L1 cells. The data show that ginsenoside Rg3...
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Veröffentlicht in: | Phytotherapy research 2009-02, Vol.23 (2), p.262-266 |
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description | Ginsenosides, the active component of ginseng, exerts antidiabetic and anticancer effects. This study investigated the molecular basis of ginsenoside Rg3, a red ginseng rich constituent, focusing on its ability to inhibit adipocyte differentiation in 3T3-L1 cells. The data show that ginsenoside Rg3 was effective in the inhibition of adipocyte differentiation. This inhibitory effect of ginsenoside Rg3 on adipocyte differentiation was accompanied by PPAR-γ inhibition in rosiglitazone-treated cells. The study also tested whether AMP-activated protein kinase (AMPK) activation was involved in the inhibitory effects of ginsenoside Rg3. AMPK plays a role in maintaining health in the context of diseases such as type 2 diabetes, obesity and cancer. AMPK was reported to control nutritional and hormonal signal modulating. Rg3 significantly and time-dependently activated AMPK. Taken together, these results suggest that the antiobesity effect of red ginseng rich constituent, ginsenoside Rg3, involves the AMPK signaling pathway and PPAR-γ inhibition. Copyright © 2008 John Wiley & Sons, Ltd. |
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This study investigated the molecular basis of ginsenoside Rg3, a red ginseng rich constituent, focusing on its ability to inhibit adipocyte differentiation in 3T3-L1 cells. The data show that ginsenoside Rg3 was effective in the inhibition of adipocyte differentiation. This inhibitory effect of ginsenoside Rg3 on adipocyte differentiation was accompanied by PPAR-γ inhibition in rosiglitazone-treated cells. The study also tested whether AMP-activated protein kinase (AMPK) activation was involved in the inhibitory effects of ginsenoside Rg3. AMPK plays a role in maintaining health in the context of diseases such as type 2 diabetes, obesity and cancer. AMPK was reported to control nutritional and hormonal signal modulating. Rg3 significantly and time-dependently activated AMPK. Taken together, these results suggest that the antiobesity effect of red ginseng rich constituent, ginsenoside Rg3, involves the AMPK signaling pathway and PPAR-γ inhibition. Copyright © 2008 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.2606</identifier><identifier>PMID: 18844326</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>3T3-L1 Cells ; adipocyte differentiation ; Adipocytes - drug effects ; Adipocytes - metabolism ; AMP-activated protein kinase ; AMP-Activated Protein Kinases - metabolism ; Animals ; Anti-Obesity Agents - pharmacology ; antiobesity ; Cell Differentiation - drug effects ; Enzyme Activators - pharmacology ; Enzyme Inhibitors - pharmacology ; ginsenoside Rg3 ; Ginsenosides - pharmacology ; Mice ; Panax - chemistry ; peroxisome proliferators activated receptor-gamma ; PPAR gamma - antagonists & inhibitors ; PPAR gamma - metabolism ; Signal Transduction - drug effects</subject><ispartof>Phytotherapy research, 2009-02, Vol.23 (2), p.262-266</ispartof><rights>Copyright © 2008 John Wiley & Sons, Ltd.</rights><rights>Copyright (c) 2008 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3816-aef6ef4202d457d62a977b8698ac2d2ba00c20487434e76124a21ddbb5b2bdf83</citedby><cites>FETCH-LOGICAL-c3816-aef6ef4202d457d62a977b8698ac2d2ba00c20487434e76124a21ddbb5b2bdf83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.2606$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.2606$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18844326$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, Jin-Taek</creatorcontrib><creatorcontrib>Lee, Myoung-Su</creatorcontrib><creatorcontrib>Kim, Hyun-Jin</creatorcontrib><creatorcontrib>Sung, Mi-Jeong</creatorcontrib><creatorcontrib>Kim, Hye Young</creatorcontrib><creatorcontrib>Kim, Myung Sunny</creatorcontrib><creatorcontrib>Kwon, Dae Young</creatorcontrib><title>Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-γ signal pathways</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Ginsenosides, the active component of ginseng, exerts antidiabetic and anticancer effects. This study investigated the molecular basis of ginsenoside Rg3, a red ginseng rich constituent, focusing on its ability to inhibit adipocyte differentiation in 3T3-L1 cells. The data show that ginsenoside Rg3 was effective in the inhibition of adipocyte differentiation. This inhibitory effect of ginsenoside Rg3 on adipocyte differentiation was accompanied by PPAR-γ inhibition in rosiglitazone-treated cells. The study also tested whether AMP-activated protein kinase (AMPK) activation was involved in the inhibitory effects of ginsenoside Rg3. AMPK plays a role in maintaining health in the context of diseases such as type 2 diabetes, obesity and cancer. AMPK was reported to control nutritional and hormonal signal modulating. Rg3 significantly and time-dependently activated AMPK. Taken together, these results suggest that the antiobesity effect of red ginseng rich constituent, ginsenoside Rg3, involves the AMPK signaling pathway and PPAR-γ inhibition. Copyright © 2008 John Wiley & Sons, Ltd.</description><subject>3T3-L1 Cells</subject><subject>adipocyte differentiation</subject><subject>Adipocytes - drug effects</subject><subject>Adipocytes - metabolism</subject><subject>AMP-activated protein kinase</subject><subject>AMP-Activated Protein Kinases - metabolism</subject><subject>Animals</subject><subject>Anti-Obesity Agents - pharmacology</subject><subject>antiobesity</subject><subject>Cell Differentiation - drug effects</subject><subject>Enzyme Activators - pharmacology</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>ginsenoside Rg3</subject><subject>Ginsenosides - pharmacology</subject><subject>Mice</subject><subject>Panax - chemistry</subject><subject>peroxisome proliferators activated receptor-gamma</subject><subject>PPAR gamma - antagonists & inhibitors</subject><subject>PPAR gamma - metabolism</subject><subject>Signal Transduction - drug effects</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M1u00AUhuERAtG0IHEFMCvExuXM_3gZVbRFBIjSVrAbjT1n0gHHDh6nJdfFfXBNuIoFK1Zn8-jT0UvICwanDIC_3Q79KdegH5EZg7IsmDLiMZlBqVghmf16RI5z_gYAJQf5lBwxa6UUXM_I1bwdUldhTsOeYoxYD7SLdJ3ajG2XU0C6Wgua2ruuucNMh1uk84_LD9S3gS6X81Xx-xfNad36hm79cHvv9_kZeRJ9k_H5dE_Izfm767PLYvH54v3ZfFHUwjJdeIwao-TAg1QmaO5LYyqrS-trHnjlAerxXWukkGg049JzFkJVqYpXIVpxQl4fdrd992OHeXCblGtsGt9it8tOa6u4smaEbw6w7ruce4xu26eN7_eOgXsI6MaA7iHgSF9Om7tqg-EfnIqNoDiA-9Tg_r9Dbnm9mgYnn_KAP_9633932gij3JdPF86c68UYYuXK0b86-Og759d9yu7migMTwJS1oKT4A3Ndkbg</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Hwang, Jin-Taek</creator><creator>Lee, Myoung-Su</creator><creator>Kim, Hyun-Jin</creator><creator>Sung, Mi-Jeong</creator><creator>Kim, Hye Young</creator><creator>Kim, Myung Sunny</creator><creator>Kwon, Dae Young</creator><general>John Wiley & Sons, Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200902</creationdate><title>Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-γ signal pathways</title><author>Hwang, Jin-Taek ; Lee, Myoung-Su ; Kim, Hyun-Jin ; Sung, Mi-Jeong ; Kim, Hye Young ; Kim, Myung Sunny ; Kwon, Dae Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3816-aef6ef4202d457d62a977b8698ac2d2ba00c20487434e76124a21ddbb5b2bdf83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>3T3-L1 Cells</topic><topic>adipocyte differentiation</topic><topic>Adipocytes - drug effects</topic><topic>Adipocytes - metabolism</topic><topic>AMP-activated protein kinase</topic><topic>AMP-Activated Protein Kinases - metabolism</topic><topic>Animals</topic><topic>Anti-Obesity Agents - pharmacology</topic><topic>antiobesity</topic><topic>Cell Differentiation - drug effects</topic><topic>Enzyme Activators - pharmacology</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>ginsenoside Rg3</topic><topic>Ginsenosides - pharmacology</topic><topic>Mice</topic><topic>Panax - chemistry</topic><topic>peroxisome proliferators activated receptor-gamma</topic><topic>PPAR gamma - antagonists & inhibitors</topic><topic>PPAR gamma - metabolism</topic><topic>Signal Transduction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, Jin-Taek</creatorcontrib><creatorcontrib>Lee, Myoung-Su</creatorcontrib><creatorcontrib>Kim, Hyun-Jin</creatorcontrib><creatorcontrib>Sung, Mi-Jeong</creatorcontrib><creatorcontrib>Kim, Hye Young</creatorcontrib><creatorcontrib>Kim, Myung Sunny</creatorcontrib><creatorcontrib>Kwon, Dae Young</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Jin-Taek</au><au>Lee, Myoung-Su</au><au>Kim, Hyun-Jin</au><au>Sung, Mi-Jeong</au><au>Kim, Hye Young</au><au>Kim, Myung Sunny</au><au>Kwon, Dae Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-γ signal pathways</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2009-02</date><risdate>2009</risdate><volume>23</volume><issue>2</issue><spage>262</spage><epage>266</epage><pages>262-266</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Ginsenosides, the active component of ginseng, exerts antidiabetic and anticancer effects. This study investigated the molecular basis of ginsenoside Rg3, a red ginseng rich constituent, focusing on its ability to inhibit adipocyte differentiation in 3T3-L1 cells. The data show that ginsenoside Rg3 was effective in the inhibition of adipocyte differentiation. This inhibitory effect of ginsenoside Rg3 on adipocyte differentiation was accompanied by PPAR-γ inhibition in rosiglitazone-treated cells. The study also tested whether AMP-activated protein kinase (AMPK) activation was involved in the inhibitory effects of ginsenoside Rg3. AMPK plays a role in maintaining health in the context of diseases such as type 2 diabetes, obesity and cancer. AMPK was reported to control nutritional and hormonal signal modulating. Rg3 significantly and time-dependently activated AMPK. Taken together, these results suggest that the antiobesity effect of red ginseng rich constituent, ginsenoside Rg3, involves the AMPK signaling pathway and PPAR-γ inhibition. Copyright © 2008 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>18844326</pmid><doi>10.1002/ptr.2606</doi><tpages>5</tpages></addata></record> |
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subjects | 3T3-L1 Cells adipocyte differentiation Adipocytes - drug effects Adipocytes - metabolism AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Animals Anti-Obesity Agents - pharmacology antiobesity Cell Differentiation - drug effects Enzyme Activators - pharmacology Enzyme Inhibitors - pharmacology ginsenoside Rg3 Ginsenosides - pharmacology Mice Panax - chemistry peroxisome proliferators activated receptor-gamma PPAR gamma - antagonists & inhibitors PPAR gamma - metabolism Signal Transduction - drug effects |
title | Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-γ signal pathways |
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