Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-γ signal pathways

Ginsenosides, the active component of ginseng, exerts antidiabetic and anticancer effects. This study investigated the molecular basis of ginsenoside Rg3, a red ginseng rich constituent, focusing on its ability to inhibit adipocyte differentiation in 3T3-L1 cells. The data show that ginsenoside Rg3...

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Veröffentlicht in:Phytotherapy research 2009-02, Vol.23 (2), p.262-266
Hauptverfasser: Hwang, Jin-Taek, Lee, Myoung-Su, Kim, Hyun-Jin, Sung, Mi-Jeong, Kim, Hye Young, Kim, Myung Sunny, Kwon, Dae Young
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container_issue 2
container_start_page 262
container_title Phytotherapy research
container_volume 23
creator Hwang, Jin-Taek
Lee, Myoung-Su
Kim, Hyun-Jin
Sung, Mi-Jeong
Kim, Hye Young
Kim, Myung Sunny
Kwon, Dae Young
description Ginsenosides, the active component of ginseng, exerts antidiabetic and anticancer effects. This study investigated the molecular basis of ginsenoside Rg3, a red ginseng rich constituent, focusing on its ability to inhibit adipocyte differentiation in 3T3-L1 cells. The data show that ginsenoside Rg3 was effective in the inhibition of adipocyte differentiation. This inhibitory effect of ginsenoside Rg3 on adipocyte differentiation was accompanied by PPAR-γ inhibition in rosiglitazone-treated cells. The study also tested whether AMP-activated protein kinase (AMPK) activation was involved in the inhibitory effects of ginsenoside Rg3. AMPK plays a role in maintaining health in the context of diseases such as type 2 diabetes, obesity and cancer. AMPK was reported to control nutritional and hormonal signal modulating. Rg3 significantly and time-dependently activated AMPK. Taken together, these results suggest that the antiobesity effect of red ginseng rich constituent, ginsenoside Rg3, involves the AMPK signaling pathway and PPAR-γ inhibition. Copyright © 2008 John Wiley & Sons, Ltd.
doi_str_mv 10.1002/ptr.2606
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Res</addtitle><description>Ginsenosides, the active component of ginseng, exerts antidiabetic and anticancer effects. This study investigated the molecular basis of ginsenoside Rg3, a red ginseng rich constituent, focusing on its ability to inhibit adipocyte differentiation in 3T3-L1 cells. The data show that ginsenoside Rg3 was effective in the inhibition of adipocyte differentiation. This inhibitory effect of ginsenoside Rg3 on adipocyte differentiation was accompanied by PPAR-γ inhibition in rosiglitazone-treated cells. The study also tested whether AMP-activated protein kinase (AMPK) activation was involved in the inhibitory effects of ginsenoside Rg3. AMPK plays a role in maintaining health in the context of diseases such as type 2 diabetes, obesity and cancer. AMPK was reported to control nutritional and hormonal signal modulating. Rg3 significantly and time-dependently activated AMPK. Taken together, these results suggest that the antiobesity effect of red ginseng rich constituent, ginsenoside Rg3, involves the AMPK signaling pathway and PPAR-γ inhibition. 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subjects 3T3-L1 Cells
adipocyte differentiation
Adipocytes - drug effects
Adipocytes - metabolism
AMP-activated protein kinase
AMP-Activated Protein Kinases - metabolism
Animals
Anti-Obesity Agents - pharmacology
antiobesity
Cell Differentiation - drug effects
Enzyme Activators - pharmacology
Enzyme Inhibitors - pharmacology
ginsenoside Rg3
Ginsenosides - pharmacology
Mice
Panax - chemistry
peroxisome proliferators activated receptor-gamma
PPAR gamma - antagonists & inhibitors
PPAR gamma - metabolism
Signal Transduction - drug effects
title Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-γ signal pathways
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