Visual outcome after discontinuation of corticosteroids in atypical severe central serous chorioretinopathy
To elucidate the effect of discontinuation of corticosteroids in patients with atypical severe central serous chorioretinopathy (CSC) on retinal reattachment, resolution of retinal pigment epithelium (RPE) leaks, and improvement in visual acuity (VA). Prospective, noncomparative, observational case...
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| Veröffentlicht in: | Ophthalmology (Rochester, Minn.) Minn.), 2004-09, Vol.111 (9), p.1708-1714 |
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| creator | Sharma, Tarun Shah, Nitant Rao, Madhav Gopal, Lingam Shanmugam, Mahesh P. Gopalakrishnan, Mahesh Bhende, Pramod Bhende, Muna Shetty, Nitin S. Baluswamy, Sukumar |
| description | To elucidate the effect of discontinuation of corticosteroids in patients with atypical severe central serous chorioretinopathy (CSC) on retinal reattachment, resolution of retinal pigment epithelium (RPE) leaks, and improvement in visual acuity (VA).
Prospective, noncomparative, observational case series.
Twenty-four eyes of 17 patients who were being treated with corticosteroids for atypical severe CSC. Of these 17 patients, 16 were treated inappropriately with corticosteroids for their ocular condition; presumably, these patients' conditions were misdiagnosed, and they were thought to have choroiditis, Harada's syndrome, or similar entities, and not central serous chorioretinopathy.
Observation or laser photocoagulation.
Reattachment of the retina, obliteration of RPE leaks on fundus fluorescein angiography, and improvement in Snellen VA.
Discontinuation of corticosteroids resulted in reattachment of the retina in 21 eyes (87.5%), with median time to reattachment of 49 days (range, 32–400); only 3 eyes required laser photocoagulation. Fundus fluorescein angiography showed obliteration of RPE leaks at a median period of 75 days (range, 32–400) in the observed eyes; the median VA improved from 20/80 to 20/30. The mean follow-up was 16.5 months.
Discontinuation of corticosteroids in atypical CSC helped in obliteration of RPE leaks and retinal reattachment in 87.5% of the eyes without laser treatment, and improvement in VA was observed. |
| doi_str_mv | 10.1016/j.ophtha.2004.03.025 |
| format | Article |
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Prospective, noncomparative, observational case series.
Twenty-four eyes of 17 patients who were being treated with corticosteroids for atypical severe CSC. Of these 17 patients, 16 were treated inappropriately with corticosteroids for their ocular condition; presumably, these patients' conditions were misdiagnosed, and they were thought to have choroiditis, Harada's syndrome, or similar entities, and not central serous chorioretinopathy.
Observation or laser photocoagulation.
Reattachment of the retina, obliteration of RPE leaks on fundus fluorescein angiography, and improvement in Snellen VA.
Discontinuation of corticosteroids resulted in reattachment of the retina in 21 eyes (87.5%), with median time to reattachment of 49 days (range, 32–400); only 3 eyes required laser photocoagulation. Fundus fluorescein angiography showed obliteration of RPE leaks at a median period of 75 days (range, 32–400) in the observed eyes; the median VA improved from 20/80 to 20/30. The mean follow-up was 16.5 months.
Discontinuation of corticosteroids in atypical CSC helped in obliteration of RPE leaks and retinal reattachment in 87.5% of the eyes without laser treatment, and improvement in VA was observed.</description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/j.ophtha.2004.03.025</identifier><identifier>PMID: 15350327</identifier><identifier>CODEN: OPHTDG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Capillary Permeability - drug effects ; Capillary Permeability - physiology ; Choroid Diseases - drug therapy ; Choroid Diseases - physiopathology ; Exudates and Transudates ; Female ; Fibrosis ; Fluorescein Angiography ; Glucocorticoids - therapeutic use ; Humans ; Male ; Medical sciences ; Middle Aged ; Ophthalmology ; Pigment Epithelium of Eye - drug effects ; Pigment Epithelium of Eye - physiopathology ; Prospective Studies ; Retinal Detachment - drug therapy ; Retinal Detachment - physiopathology ; Retinopathies ; Visual Acuity - drug effects ; Visual Acuity - physiology</subject><ispartof>Ophthalmology (Rochester, Minn.), 2004-09, Vol.111 (9), p.1708-1714</ispartof><rights>2004 American Academy of Ophthalmology</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-71e1b9ae237fa2fab3bb28a202c410eb239d2a4352c232cd595a6b81949774a93</citedby><cites>FETCH-LOGICAL-c388t-71e1b9ae237fa2fab3bb28a202c410eb239d2a4352c232cd595a6b81949774a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0161642004005585$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16078759$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15350327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, Tarun</creatorcontrib><creatorcontrib>Shah, Nitant</creatorcontrib><creatorcontrib>Rao, Madhav</creatorcontrib><creatorcontrib>Gopal, Lingam</creatorcontrib><creatorcontrib>Shanmugam, Mahesh P.</creatorcontrib><creatorcontrib>Gopalakrishnan, Mahesh</creatorcontrib><creatorcontrib>Bhende, Pramod</creatorcontrib><creatorcontrib>Bhende, Muna</creatorcontrib><creatorcontrib>Shetty, Nitin S.</creatorcontrib><creatorcontrib>Baluswamy, Sukumar</creatorcontrib><title>Visual outcome after discontinuation of corticosteroids in atypical severe central serous chorioretinopathy</title><title>Ophthalmology (Rochester, Minn.)</title><addtitle>Ophthalmology</addtitle><description>To elucidate the effect of discontinuation of corticosteroids in patients with atypical severe central serous chorioretinopathy (CSC) on retinal reattachment, resolution of retinal pigment epithelium (RPE) leaks, and improvement in visual acuity (VA).
Prospective, noncomparative, observational case series.
Twenty-four eyes of 17 patients who were being treated with corticosteroids for atypical severe CSC. Of these 17 patients, 16 were treated inappropriately with corticosteroids for their ocular condition; presumably, these patients' conditions were misdiagnosed, and they were thought to have choroiditis, Harada's syndrome, or similar entities, and not central serous chorioretinopathy.
Observation or laser photocoagulation.
Reattachment of the retina, obliteration of RPE leaks on fundus fluorescein angiography, and improvement in Snellen VA.
Discontinuation of corticosteroids resulted in reattachment of the retina in 21 eyes (87.5%), with median time to reattachment of 49 days (range, 32–400); only 3 eyes required laser photocoagulation. Fundus fluorescein angiography showed obliteration of RPE leaks at a median period of 75 days (range, 32–400) in the observed eyes; the median VA improved from 20/80 to 20/30. The mean follow-up was 16.5 months.
Discontinuation of corticosteroids in atypical CSC helped in obliteration of RPE leaks and retinal reattachment in 87.5% of the eyes without laser treatment, and improvement in VA was observed.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Capillary Permeability - drug effects</subject><subject>Capillary Permeability - physiology</subject><subject>Choroid Diseases - drug therapy</subject><subject>Choroid Diseases - physiopathology</subject><subject>Exudates and Transudates</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Fluorescein Angiography</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Pigment Epithelium of Eye - drug effects</subject><subject>Pigment Epithelium of Eye - physiopathology</subject><subject>Prospective Studies</subject><subject>Retinal Detachment - drug therapy</subject><subject>Retinal Detachment - physiopathology</subject><subject>Retinopathies</subject><subject>Visual Acuity - drug effects</subject><subject>Visual Acuity - physiology</subject><issn>0161-6420</issn><issn>1549-4713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEURcOgzLSj_0AkG91Vmbwk9bERZHBGYcCNug2vUq_otN2VMkkN9L83bTfMzlUIOfdycxh7K0UthWw-7uqwbPMWaxBC10LVAswV20ij-0q3Ur1gm4LJqtEgbtirlHZCiKZR-prdSKOMUNBu2O9fPq2452HNLhyI45Qp8tEnF-bs5xWzDzMPE3chZu9CKs_Bj4n7mWM-Lt6VcKInisQdzTn-u8awJu62IfoQqdSEBfP2-Jq9nHCf6M3lvGU_77_8uPtaPX5_-Hb3-bFyquty1UqSQ48Eqp0QJhzUMECHIMBpKWgA1Y-AWhlwoMCNpjfYDJ3sdd-2Gnt1yz6ce5cY_qyUsj2U_9B-jzOVYbZpOgMAXQH1GXQxpBRpskv0B4xHK4U9SbY7e5ZsT5KtULZILrF3l_51OND4HLpYLcD7C4Cp-Jkizs6nZ64Rbdea09BPZ46KjSdP0SbnaXY0-kgu2zH4_y_5C6aMn0k</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Sharma, Tarun</creator><creator>Shah, Nitant</creator><creator>Rao, Madhav</creator><creator>Gopal, Lingam</creator><creator>Shanmugam, Mahesh P.</creator><creator>Gopalakrishnan, Mahesh</creator><creator>Bhende, Pramod</creator><creator>Bhende, Muna</creator><creator>Shetty, Nitin S.</creator><creator>Baluswamy, Sukumar</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Visual outcome after discontinuation of corticosteroids in atypical severe central serous chorioretinopathy</title><author>Sharma, Tarun ; Shah, Nitant ; Rao, Madhav ; Gopal, Lingam ; Shanmugam, Mahesh P. ; Gopalakrishnan, Mahesh ; Bhende, Pramod ; Bhende, Muna ; Shetty, Nitin S. ; Baluswamy, Sukumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-71e1b9ae237fa2fab3bb28a202c410eb239d2a4352c232cd595a6b81949774a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Capillary Permeability - drug effects</topic><topic>Capillary Permeability - physiology</topic><topic>Choroid Diseases - drug therapy</topic><topic>Choroid Diseases - physiopathology</topic><topic>Exudates and Transudates</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Fluorescein Angiography</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Pigment Epithelium of Eye - drug effects</topic><topic>Pigment Epithelium of Eye - physiopathology</topic><topic>Prospective Studies</topic><topic>Retinal Detachment - drug therapy</topic><topic>Retinal Detachment - physiopathology</topic><topic>Retinopathies</topic><topic>Visual Acuity - drug effects</topic><topic>Visual Acuity - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, Tarun</creatorcontrib><creatorcontrib>Shah, Nitant</creatorcontrib><creatorcontrib>Rao, Madhav</creatorcontrib><creatorcontrib>Gopal, Lingam</creatorcontrib><creatorcontrib>Shanmugam, Mahesh P.</creatorcontrib><creatorcontrib>Gopalakrishnan, Mahesh</creatorcontrib><creatorcontrib>Bhende, Pramod</creatorcontrib><creatorcontrib>Bhende, Muna</creatorcontrib><creatorcontrib>Shetty, Nitin S.</creatorcontrib><creatorcontrib>Baluswamy, Sukumar</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmology (Rochester, Minn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Tarun</au><au>Shah, Nitant</au><au>Rao, Madhav</au><au>Gopal, Lingam</au><au>Shanmugam, Mahesh P.</au><au>Gopalakrishnan, Mahesh</au><au>Bhende, Pramod</au><au>Bhende, Muna</au><au>Shetty, Nitin S.</au><au>Baluswamy, Sukumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visual outcome after discontinuation of corticosteroids in atypical severe central serous chorioretinopathy</atitle><jtitle>Ophthalmology (Rochester, Minn.)</jtitle><addtitle>Ophthalmology</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>111</volume><issue>9</issue><spage>1708</spage><epage>1714</epage><pages>1708-1714</pages><issn>0161-6420</issn><eissn>1549-4713</eissn><coden>OPHTDG</coden><abstract>To elucidate the effect of discontinuation of corticosteroids in patients with atypical severe central serous chorioretinopathy (CSC) on retinal reattachment, resolution of retinal pigment epithelium (RPE) leaks, and improvement in visual acuity (VA).
Prospective, noncomparative, observational case series.
Twenty-four eyes of 17 patients who were being treated with corticosteroids for atypical severe CSC. Of these 17 patients, 16 were treated inappropriately with corticosteroids for their ocular condition; presumably, these patients' conditions were misdiagnosed, and they were thought to have choroiditis, Harada's syndrome, or similar entities, and not central serous chorioretinopathy.
Observation or laser photocoagulation.
Reattachment of the retina, obliteration of RPE leaks on fundus fluorescein angiography, and improvement in Snellen VA.
Discontinuation of corticosteroids resulted in reattachment of the retina in 21 eyes (87.5%), with median time to reattachment of 49 days (range, 32–400); only 3 eyes required laser photocoagulation. Fundus fluorescein angiography showed obliteration of RPE leaks at a median period of 75 days (range, 32–400) in the observed eyes; the median VA improved from 20/80 to 20/30. The mean follow-up was 16.5 months.
Discontinuation of corticosteroids in atypical CSC helped in obliteration of RPE leaks and retinal reattachment in 87.5% of the eyes without laser treatment, and improvement in VA was observed.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15350327</pmid><doi>10.1016/j.ophtha.2004.03.025</doi><tpages>7</tpages></addata></record> |
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| ispartof | Ophthalmology (Rochester, Minn.), 2004-09, Vol.111 (9), p.1708-1714 |
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| subjects | Adult Biological and medical sciences Capillary Permeability - drug effects Capillary Permeability - physiology Choroid Diseases - drug therapy Choroid Diseases - physiopathology Exudates and Transudates Female Fibrosis Fluorescein Angiography Glucocorticoids - therapeutic use Humans Male Medical sciences Middle Aged Ophthalmology Pigment Epithelium of Eye - drug effects Pigment Epithelium of Eye - physiopathology Prospective Studies Retinal Detachment - drug therapy Retinal Detachment - physiopathology Retinopathies Visual Acuity - drug effects Visual Acuity - physiology |
| title | Visual outcome after discontinuation of corticosteroids in atypical severe central serous chorioretinopathy |
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