Synthesis of amphiphilic poly(tetraethylene glycol succinate) and the thermosensitivity of its aggregation in water
Amphiphilic biodegradable polyester, poly(tetraethylene glycol succinate) (PTEGSuc), was synthesized via melt polycondensation of tetraethylene glycol and succinic acid on catalysis of p‐toluenesulfonic acid. It was observed that PTEGSuc could self‐assemble into micelles in water. In addition, therm...
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| Veröffentlicht in: | Journal of Biomedical Materials Research Part B 2009-03, Vol.88A (3), p.769-777 |
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| creator | Chen, Shusen Wang, Yinong Fan, Yunge Ma, Jianbiao |
| description | Amphiphilic biodegradable polyester, poly(tetraethylene glycol succinate) (PTEGSuc), was synthesized via melt polycondensation of tetraethylene glycol and succinic acid on catalysis of p‐toluenesulfonic acid. It was observed that PTEGSuc could self‐assemble into micelles in water. In addition, thermosensitivity of PTEGSuc aggregation in water was first found in the experiment, and the critical aggregation temperatures could be controlled by solution concentration. Transmission electron microscopy was used to investigate the micellar morphologies of PTEGSuc in different solvents. It was found that particle shape is almost round although the micellar morphology is different depending on the solvent used. Based on the perfect properties, especially in micelle formation and thermosensitivity, PTEGSuc is promising in biomedical field as carrier of drug delivery system, scaffold of tissue engineering, and other medical devices. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009 |
| doi_str_mv | 10.1002/jbm.a.31909 |
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It was observed that PTEGSuc could self‐assemble into micelles in water. In addition, thermosensitivity of PTEGSuc aggregation in water was first found in the experiment, and the critical aggregation temperatures could be controlled by solution concentration. Transmission electron microscopy was used to investigate the micellar morphologies of PTEGSuc in different solvents. It was found that particle shape is almost round although the micellar morphology is different depending on the solvent used. Based on the perfect properties, especially in micelle formation and thermosensitivity, PTEGSuc is promising in biomedical field as carrier of drug delivery system, scaffold of tissue engineering, and other medical devices. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</description><identifier>ISSN: 1549-3296</identifier><identifier>EISSN: 1552-4965</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.a.31909</identifier><identifier>PMID: 18357563</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>aggregation ; amphiphilic biodegradable polyester ; Hydrophobic and Hydrophilic Interactions ; Magnetic Resonance Spectroscopy ; Micelles ; Microscopy, Electron, Transmission ; Molecular Structure ; poly(tetraethylene glycol succinate) ; Polyesters - chemical synthesis ; Polyesters - chemistry ; Polyethylene Glycols - chemical synthesis ; Polyethylene Glycols - chemistry ; polymeric micelles ; Sensitivity and Specificity ; Solubility ; Spectroscopy, Fourier Transform Infrared ; Temperature ; thermosensitivity ; Titrimetry ; Water - chemistry</subject><ispartof>Journal of Biomedical Materials Research Part B, 2009-03, Vol.88A (3), p.769-777</ispartof><rights>Copyright © 2008 Wiley Periodicals, Inc.</rights><rights>(c) 2008 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4299-366a170a73ea809d50804c8945e4c9a7d7cf0c9b632bc1138d008967a7d3740e3</citedby><cites>FETCH-LOGICAL-c4299-366a170a73ea809d50804c8945e4c9a7d7cf0c9b632bc1138d008967a7d3740e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.a.31909$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.a.31909$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18357563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Shusen</creatorcontrib><creatorcontrib>Wang, Yinong</creatorcontrib><creatorcontrib>Fan, Yunge</creatorcontrib><creatorcontrib>Ma, Jianbiao</creatorcontrib><title>Synthesis of amphiphilic poly(tetraethylene glycol succinate) and the thermosensitivity of its aggregation in water</title><title>Journal of Biomedical Materials Research Part B</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Amphiphilic biodegradable polyester, poly(tetraethylene glycol succinate) (PTEGSuc), was synthesized via melt polycondensation of tetraethylene glycol and succinic acid on catalysis of p‐toluenesulfonic acid. It was observed that PTEGSuc could self‐assemble into micelles in water. In addition, thermosensitivity of PTEGSuc aggregation in water was first found in the experiment, and the critical aggregation temperatures could be controlled by solution concentration. Transmission electron microscopy was used to investigate the micellar morphologies of PTEGSuc in different solvents. It was found that particle shape is almost round although the micellar morphology is different depending on the solvent used. Based on the perfect properties, especially in micelle formation and thermosensitivity, PTEGSuc is promising in biomedical field as carrier of drug delivery system, scaffold of tissue engineering, and other medical devices. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</description><subject>aggregation</subject><subject>amphiphilic biodegradable polyester</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Micelles</subject><subject>Microscopy, Electron, Transmission</subject><subject>Molecular Structure</subject><subject>poly(tetraethylene glycol succinate)</subject><subject>Polyesters - chemical synthesis</subject><subject>Polyesters - chemistry</subject><subject>Polyethylene Glycols - chemical synthesis</subject><subject>Polyethylene Glycols - chemistry</subject><subject>polymeric micelles</subject><subject>Sensitivity and Specificity</subject><subject>Solubility</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Temperature</subject><subject>thermosensitivity</subject><subject>Titrimetry</subject><subject>Water - chemistry</subject><issn>1549-3296</issn><issn>1552-4965</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEURi0Eog9YsUdeISo0wY_xawkFCqgUxEOV2FiO5yZx8cwE26HMv8chAXZUsmVLPt_RlT-EHlAyo4Swp1fzfuZmnBpibqFDKgRrWiPF7e29NQ1nRh6go5yvKiyJYHfRAdVcKCH5IcqfpqGsIIeMxwV2_XoV6orB4_UYp8cFSnJQVlOEAfAyTn6MOG-8D4MrcILd0OEa3-7UjxmGHEr4Ecq0tYWSsVsuEyxdCeOAw4CvayrdQ3cWLma4vz-P0ZdXLz-fvm7O35-9OX123viWmTq4lI4q4hQHp4npBNGk9dq0AlpvnOqUXxBv5pKzuaeU644QbaSqL1y1BPgxerTzrtP4fQO52D5kDzG6AcZNtlJqQRmjN4L1C5XWnN8IMiIMU1pV8MkO9GnMOcHCrlPoXZosJXbbmq2tWWd_t1bph3vtZt5D94_d11QBugOuQ4Tpfy779vm7P9Jmlwm5wM-_GZe-Wam4Evby4sx-NB8uv17oF1bxX8nCsvg</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Chen, Shusen</creator><creator>Wang, Yinong</creator><creator>Fan, Yunge</creator><creator>Ma, Jianbiao</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>Synthesis of amphiphilic poly(tetraethylene glycol succinate) and the thermosensitivity of its aggregation in water</title><author>Chen, Shusen ; Wang, Yinong ; Fan, Yunge ; Ma, Jianbiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4299-366a170a73ea809d50804c8945e4c9a7d7cf0c9b632bc1138d008967a7d3740e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>aggregation</topic><topic>amphiphilic biodegradable polyester</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Micelles</topic><topic>Microscopy, Electron, Transmission</topic><topic>Molecular Structure</topic><topic>poly(tetraethylene glycol succinate)</topic><topic>Polyesters - chemical synthesis</topic><topic>Polyesters - chemistry</topic><topic>Polyethylene Glycols - chemical synthesis</topic><topic>Polyethylene Glycols - chemistry</topic><topic>polymeric micelles</topic><topic>Sensitivity and Specificity</topic><topic>Solubility</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Temperature</topic><topic>thermosensitivity</topic><topic>Titrimetry</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Shusen</creatorcontrib><creatorcontrib>Wang, Yinong</creatorcontrib><creatorcontrib>Fan, Yunge</creatorcontrib><creatorcontrib>Ma, Jianbiao</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Biomedical Materials Research Part B</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Shusen</au><au>Wang, Yinong</au><au>Fan, Yunge</au><au>Ma, Jianbiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of amphiphilic poly(tetraethylene glycol succinate) and the thermosensitivity of its aggregation in water</atitle><jtitle>Journal of Biomedical Materials Research Part B</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>88A</volume><issue>3</issue><spage>769</spage><epage>777</epage><pages>769-777</pages><issn>1549-3296</issn><eissn>1552-4965</eissn><eissn>1552-4981</eissn><abstract>Amphiphilic biodegradable polyester, poly(tetraethylene glycol succinate) (PTEGSuc), was synthesized via melt polycondensation of tetraethylene glycol and succinic acid on catalysis of p‐toluenesulfonic acid. It was observed that PTEGSuc could self‐assemble into micelles in water. In addition, thermosensitivity of PTEGSuc aggregation in water was first found in the experiment, and the critical aggregation temperatures could be controlled by solution concentration. Transmission electron microscopy was used to investigate the micellar morphologies of PTEGSuc in different solvents. It was found that particle shape is almost round although the micellar morphology is different depending on the solvent used. Based on the perfect properties, especially in micelle formation and thermosensitivity, PTEGSuc is promising in biomedical field as carrier of drug delivery system, scaffold of tissue engineering, and other medical devices. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>18357563</pmid><doi>10.1002/jbm.a.31909</doi><tpages>9</tpages></addata></record> |
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| subjects | aggregation amphiphilic biodegradable polyester Hydrophobic and Hydrophilic Interactions Magnetic Resonance Spectroscopy Micelles Microscopy, Electron, Transmission Molecular Structure poly(tetraethylene glycol succinate) Polyesters - chemical synthesis Polyesters - chemistry Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry polymeric micelles Sensitivity and Specificity Solubility Spectroscopy, Fourier Transform Infrared Temperature thermosensitivity Titrimetry Water - chemistry |
| title | Synthesis of amphiphilic poly(tetraethylene glycol succinate) and the thermosensitivity of its aggregation in water |
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