Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects

Ghrelin is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R), two subtypes of which have been identified and named GHS-R1a and GHS-R1b. Evidence has been provided that ghrelin and its receptors are expressed in the adrenal gland, and we have investigated the possible role of t...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2004-08, Vol.25 (8), p.1269-1277
Hauptverfasser:	Mazzocchi, Giuseppina, Neri, Giuliano, Rucinski, Marcin, Rebuffat, Piera, Spinazzi, Raffaella, Malendowicz, Ludwik K., Nussdorfer, Gastone G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal cortex Apoptosis Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Cell proliferation Cell Proliferation - drug effects Cells, Cultured Fundamental and applied biological sciences. Psychology Ghrelin GHS-R Humans Mitogen-Activated Protein Kinases - metabolism Peptide Hormones - pharmacology Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Ghrelin RNA, Messenger - genetics RNA, Messenger - metabolism Vertebrates: endocrinology Zona Glomerulosa - cytology Zona Glomerulosa - drug effects Zona Glomerulosa - growth & development
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