Inhibition of the 20S Proteosome by a Protein Proteinase Inhibitor: Evidence That a Natural Serine Proteinase Inhibitor Can Inhibit a Threonine Proteinase

The 20S proteasome (20S) is an intracellular threonine proteinase (Mr 750,000) that plays important roles in many cellular regulations. Several synthetic peptide inhibitors and bacteria-derived inhibitors such as lactacystin and epoxomicin have been identified as potent proteasome inhibitors. Howeve...

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Veröffentlicht in:Journal of biochemistry (Tokyo) 2009-02, Vol.145 (2), p.217-227
Hauptverfasser: Yabe, Kimihiko, Koide, Takehiko
Format: Artikel
Sprache:eng
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